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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Sensitization of Burkholderia cepacia to antibiotics by cationic drugs.

Chlorpromazine and prochlorperazine have previously been shown to enhance the susceptibility of Burkholderia cepacia to aminoglycosides. To screen other non-antibiotic drugs containing similar amine (-N-CH3) groups, we examined a range of such agents that are in current clinical use for the treatment of non-infectious diseases, in combination with antibiotics that are ineffective against B. cepacia. At a concentration of 0.2 mM, theobromine, theophylline, trifluoperazine, fluophenazine and coumarin-152 significantly reduced (by four-fold) the MICs of gentamicin and ceftazidime. Theobromine and theophylline also reduced the MICs of amikacin and azithromycin.[1]


  1. Sensitization of Burkholderia cepacia to antibiotics by cationic drugs. Rajyaguru, J.M., Muszynski, M.J. J. Antimicrob. Chemother. (1998) [Pubmed]
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