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Sjöborg, M. et al.

Expression of platelet-derived growth factor after intrastriatal ibotenic acid injury.

The expression of platelet-derived growth factor (PDGF) was studied in a rat model of Huntington's disease, produced by unilateral intrastriatal ibotenic acid injections. The most pronounced effect registered was that the number of PDGF-immunoreactive cells increased in the lesioned area up to 10 weeks after the surgery. Double immunofluorescence staining indicated that the PDGF-positive cells were astrocytes. The increased PDGF immunoreactivity was associated with only minor changes in total PDGF mRNA and PDGF protein levels in the lesioned area. Reverse transcription-polymerase chain reaction (RT-PCR) demonstrated a slight increase in PDGF mRNA after ibotenic acid lesion, but this was not reflected in an increase in PDGF A- and B-chain protein concentration as measured with ELISA. After sham operation an increase in PDGF protein concentration was seen, while the number of PDGF-immunoreactive cells was unchanged. The accumulation of PDGF in the astrocytes might reflect the role of PDGF in a repair process in neurodegenerative processes.[1]

References

Expression of platelet-derived growth factor after intrastriatal ibotenic acid injury. Sjöborg, M., Pietz, K., Ahgren, A., Yamada, N., Lindvall, O., Funa, K., Odin, P. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1998) [Pubmed]

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