The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Ibotenic acid     2-amino-2-(3-oxo-1,2-oxazol- 5-yl)ethanoic...

Synonyms: Ibotenate, CHEMBL284895, SureCN153359, AG-E-78364, SureCN4582627, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Ibotenic acid

  • To determine the role of the ventromedial hypoglycemia, we performed hypoglycemic clamp studies in conscious Sprague-Dawley rats with bilateral VMH lesions produced by local ibotenic acid injection 2 wk earlier [1].
  • When injected intracerebrally into newborn mice, the glutamatergic analog ibotenate induces white matter cysts mimicking human periventricular leukomalacia [2].
  • Ibotenic acid lesions of the hippocampus eliminated the majority of the label, which had been present over pyramidal cells, though labeling was increased over areas of reactive gliosis, suggesting that activated astrocytes can also synthesize CPE mRNA [3].
  • Bilateral ibotenic acid ablation of the lateral parabrachial nucleus was performed 4 weeks after induction of hypertension or sham operation [4].
  • In ibotenic acid-injected rats, hyperemia was preserved at the injection site, but the sudden decline of blood flow was abolished (maximal slope of flow decay: 5 +/- 3%/min compared with 53 +/- 8%/min at the control site; n = 5, p less than 0.001) and no significant hypoperfusion developed (103 +/- 20% of control at 60 minutes) [5].

Psychiatry related information on Ibotenic acid


High impact information on Ibotenic acid


Chemical compound and disease context of Ibotenic acid


Biological context of Ibotenic acid

  • Ibotenic acid lesions were made within the physiologically identified representation of the lower left visual field of area 17 [21].
  • Continuous recordings of penile erections, body temperature, and sleep-wake states were performed before and up to 3 weeks after ibotenic acid lesions of the preoptic forebrain in three groups of rats [22].
  • We examined the effects of bilateral ibotenic acid lesions of cat lateral suprasylvian (LS) cortex on motion perception [23].
  • Finally, BDNF exacerbated neuronal death produced by ibotenate at P0 through increased apoptosis and p75(NTR) receptors, while BDNF had no detectable effect on lesions induced at P10 [24].
  • Three days after surgery, CMRGlu and k3 (phosphorylation of FDG) were reduced similarly in the frontal cortex on the BPA-injected side and in the ibotenic acid-treated group, whereas K1 (transport rate of FDG from the plasma to brain) showed no marked changes [25].

Anatomical context of Ibotenic acid

  • This cholinergic component of Alzheimer disease can be modeled in the rat by ibotenic acid lesions of the cholinergic nucleus basalis magnocellularis [26].
  • Injection of ibotenic acid or colchicine into the caudate putamen decreased [3H]captopril-associated autoradiographic grains by 85% in the ipsilateral caudate putamen and by greater than 50% in the ipsilateral substantia nigra [27].
  • The dense labeling associated with hippocampal pyramidal cells was reduced significantly when the cells were eliminated by injection of the neurotoxin ibotenic acid but was not affected when electrolytic lesions were placed in the medial septum [28].
  • Loss of muscarinic receptors and of stimulated phospholipid labeling in ibotenate-treated hippocampus [29].
  • Electrolytic or ibotenic acid lesions of the central nucleus of the amygdala blocked fear-potentiated startle to both auditory and visual CSs, consistent with the idea that the central nucleus serves as a response independent, final common relay for fear conditioning [30].

Associations of Ibotenic acid with other chemical compounds

  • Further, IGlu is not mediated by a known metabotropic glutamate receptor since it was not activated by quisqualic acid, AP-4, ACPD, or ibotenate [31].
  • Striatal grafts derived from embryonic day 15 striatal primordia were implanted into the ibotenate-damaged host striatum of rats previously treated with 6-hydroxydopamine (6-OHDA) to destroy TH-containing dopaminergic nigrostriatal afferents [32].
  • The failure of ibotenic acid to affect LH-produced descending inhibition when microinjected into the dorsolateral pons, and the significant effect produced by lidocaine microinjected into the same area, implicates fibers of passage in the dorsolateral pons in descending inhibition of the TF reflex produced by focal electrical stimulation in the LH [33].
  • Compared with sham-operated control animals, which showed the same response as intact, nonlesioned rats, ibotenate lesions of the LDTg attenuated the stimulatory effects of intra-VTA neostigmine on DA efflux in the nucleus accumbens [34].
  • BDNF neuroprotection at P5 was maximal against lesions induced by NMDA or ibotenate but was moderate against lesions produced by an AMPA-kainate agonist [24].

Gene context of Ibotenic acid

  • In a similar manner, IL-9-overexpressing transgenic pups developed ibotenate-induced brain lesions, which were significantly larger than those induced in nontransgenic control pups [35].
  • In particular, the mutations K74Y and K317R induced dramatic triple-order-of-magnitude increases in the affinity of ibotenic acid at mGluR4, making the affinity equivalent to that of mGluR1 [36].
  • Cortical and white matter lesions induced by ibotenate at P5 were reduced by BDNF by up to 36 and 60%, respectively [24].
  • Systemically administered recombinant PRDX5 provided protection against ibotenate-induced excitotoxic stress [37].
  • In contrast, increased levels of the beta-chemokines MIP-1 alpha and -beta were seen early in the disease and were concentrated in regions of the brain rich in spongiosis, and the magnitude of responses was similar to that observed in the brains of mice injected with the glutamatergic neurotoxin ibotenic acid [38].

Analytical, diagnostic and therapeutic context of Ibotenic acid


  1. Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia. Borg, W.P., During, M.J., Sherwin, R.S., Borg, M.A., Brines, M.L., Shulman, G.I. J. Clin. Invest. (1994) [Pubmed]
  2. Melatoninergic neuroprotection of the murine periventricular white matter against neonatal excitotoxic challenge. Husson, I., Mesplès, B., Bac, P., Vamecq, J., Evrard, P., Gressens, P. Ann. Neurol. (2002) [Pubmed]
  3. Carboxypeptidase E (enkephalin convertase): mRNA distribution in rat brain by in situ hybridization. MacCumber, M.W., Snyder, S.H., Ross, C.A. J. Neurosci. (1990) [Pubmed]
  4. Effects of lateral parabrachial nucleus lesions in chronic renal hypertensive rats. Mortensen, L.H., Ohman, L.E., Haywood, J.R. Hypertension (1994) [Pubmed]
  5. The onset of postischemic hypoperfusion in rats is precipitous and may be controlled by local neurons. Frerichs, K.U., Sirén, A.L., Feuerstein, G.Z., Hallenbeck, J.M. Stroke (1992) [Pubmed]
  6. No evidence for preservation of somatostatin-containing neurons after intrastriatal injections of quinolinic acid. Davies, S.W., Roberts, P.J. Nature (1987) [Pubmed]
  7. Graft-induced behavioral recovery in an animal model of Huntington disease. Isacson, O., Dunnett, S.B., Björklund, A. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  8. Lesions of the amygdala central nucleus alter performance on a selective attention task. Holland, P.C., Han, J.S., Gallagher, M. J. Neurosci. (2000) [Pubmed]
  9. Extended temporal gradient for the retrograde and anterograde amnesia produced by ibotenate entorhinal cortex lesions in mice. Cho, Y.H., Beracochea, D., Jaffard, R. J. Neurosci. (1993) [Pubmed]
  10. Specific brain protein changes correlated with behaviourally effective brain transplants. Wets, K.M., Sinden, J., Hodges, H., Allen, Y., Marchbanks, R.M. J. Neurochem. (1991) [Pubmed]
  11. Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid. Beal, M.F., Kowall, N.W., Ellison, D.W., Mazurek, M.F., Swartz, K.J., Martin, J.B. Nature (1986) [Pubmed]
  12. Cloning, expression, and gene structure of a G protein-coupled glutamate receptor from rat brain. Houamed, K.M., Kuijper, J.L., Gilbert, T.L., Haldeman, B.A., O'Hara, P.J., Mulvihill, E.R., Almers, W., Hagen, F.S. Science (1991) [Pubmed]
  13. Delayed transneuronal death of substantia nigra neurons prevented by gamma-aminobutyric acid agonist. Saji, M., Reis, D.J. Science (1987) [Pubmed]
  14. The basal forebrain-cortical cholinergic system: interpreting the functional consequences of excitotoxic lesions. Dunnett, S.B., Everitt, B.J., Robbins, T.W. Trends Neurosci. (1991) [Pubmed]
  15. Vasoactive intestinal peptide prevents excitotoxic cell death in the murine developing brain. Gressens, P., Marret, S., Hill, J.M., Brenneman, D.E., Gozes, I., Fridkin, M., Evrard, P. J. Clin. Invest. (1997) [Pubmed]
  16. Prefrontal cortical and hippocampal modulation of haloperidol-induced catalepsy and apomorphine-induced stereotypic behaviors in the rat. Lipska, B.K., Jaskiw, G.E., Braun, A.R., Weinberger, D.R. Biol. Psychiatry (1995) [Pubmed]
  17. Neuronal TGF-beta1 mediates IL-9/mast cell interaction and exacerbates excitotoxicity in newborn mice. Mesplès, B., Fontaine, R.H., Lelièvre, V., Launay, J.M., Gressens, P. Neurobiol. Dis. (2005) [Pubmed]
  18. Glycine antagonist and NO synthase inhibitor protect the developing mouse brain against neonatal excitotoxic lesions. Marret, S., Bonnier, C., Raymackers, J.M., Delpech, A., Evrard, P., Gressens, P. Pediatr. Res. (1999) [Pubmed]
  19. Role of target tissue in regulating the development of retinal ganglion cells in the albino rat: effects of kainate lesions in the superior colliculus. Carpenter, P., Sefton, A.J., Dreher, B., Lim, W.L. J. Comp. Neurol. (1986) [Pubmed]
  20. A comparison of excitotoxic lesions of the basal forebrain by kainate, quinolinate, ibotenate, N-methyl-D-aspartate or quisqualate, and the effects on toxicity of 2-amino-5-phosphonovaleric acid and kynurenic acid in the rat. Winn, P., Stone, T.W., Latimer, M., Hastings, M.H., Clark, A.J. Br. J. Pharmacol. (1991) [Pubmed]
  21. The role of striate cortex in visual function of the cat. Pasternak, T., Tompkins, J., Olson, C.R. J. Neurosci. (1995) [Pubmed]
  22. Role of the lateral preoptic area in sleep-related erectile mechanisms and sleep generation in the rat. Schmidt, M.H., Valatx, J.L., Sakai, K., Fort, P., Jouvet, M. J. Neurosci. (2000) [Pubmed]
  23. Lesions in cat lateral suprasylvian cortex affect the perception of complex motion. Rudolph, K.K., Pasternak, T. Cereb. Cortex (1996) [Pubmed]
  24. BDNF-induced white matter neuroprotection and stage-dependent neuronal survival following a neonatal excitotoxic challenge. Husson, I., Rangon, C.M., Lelièvre, V., Bemelmans, A.P., Sachs, P., Mallet, J., Kosofsky, B.E., Gressens, P. Cereb. Cortex (2005) [Pubmed]
  25. Cholinergic projection from the basal forebrain and cerebral glucose metabolism in rats: a dynamic PET study. Ouchi, Y., Fukuyama, H., Ogawa, M., Yamauchi, H., Kimura, J., Magata, Y., Yonekura, Y., Konishi, J. J. Cereb. Blood Flow Metab. (1996) [Pubmed]
  26. Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease. Fine, A., Dunnett, S.B., Björklund, A., Iversen, S.D. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  27. Autoradiographic visualization of angiotensin-converting enzyme in rat brain with [3H]captopril: localization to a striatonigral pathway. Strittmatter, S.M., Lo, M.M., Javitch, J.A., Snyder, S.H. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  28. Neuroanatomical localization and quantification of amyloid precursor protein mRNA by in situ hybridization in the brains of normal, aneuploid, and lesioned mice. Bendotti, C., Forloni, G.L., Morgan, R.A., O'Hara, B.F., Oster-Granite, M.L., Reeves, R.H., Gearhart, J.D., Coyle, J.T. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  29. Loss of muscarinic receptors and of stimulated phospholipid labeling in ibotenate-treated hippocampus. Fisher, S.K., Frey, K.A., Agranoff, B.W. J. Neurosci. (1981) [Pubmed]
  30. Involvement of the central nucleus and basolateral complex of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli. Campeau, S., Davis, M. J. Neurosci. (1995) [Pubmed]
  31. A glutamate-activated chloride current in cone-driven ON bipolar cells of the white perch retina. Grant, G.B., Dowling, J.E. J. Neurosci. (1995) [Pubmed]
  32. Influence of mesostriatal afferents on the development and transmitter regulation of intrastriatal grafts derived from embryonic striatal primordia. Liu, F.C., Dunnett, S.B., Graybiel, A.M. J. Neurosci. (1992) [Pubmed]
  33. Brain-stem relays mediating stimulation-produced antinociception from the lateral hypothalamus in the rat. Aimone, L.D., Bauer, C.A., Gebhart, G.F. J. Neurosci. (1988) [Pubmed]
  34. Modulation of dopamine efflux in the nucleus accumbens after cholinergic stimulation of the ventral tegmental area in intact, pedunculopontine tegmental nucleus-lesioned, and laterodorsal tegmental nucleus-lesioned rats. Blaha, C.D., Allen, L.F., Das, S., Inglis, W.L., Latimer, M.P., Vincent, S.R., Winn, P. J. Neurosci. (1996) [Pubmed]
  35. Proinflammatory cytokines and interleukin-9 exacerbate excitotoxic lesions of the newborn murine neopallium. Dommergues, M.A., Patkai, J., Renauld, J.C., Evrard, P., Gressens, P. Ann. Neurol. (2000) [Pubmed]
  36. Mutation-induced quisqualic acid and ibotenic acid affinity at the metabotropic glutamate receptor subtype 4: ligand selectivity results from a synergy of several amino acid residues. Hermit, M.B., Greenwood, J.R., Bräuner-Osborne, H. J. Biol. Chem. (2004) [Pubmed]
  37. Recombinant peroxiredoxin 5 protects against excitotoxic brain lesions in newborn mice. Plaisant, F., Clippe, A., Vander Stricht, D., Knoops, B., Gressens, P. Free Radic. Biol. Med. (2003) [Pubmed]
  38. Increased expression of MIP-1 alpha and MIP-1 beta mRNAs in the brain correlates spatially and temporally with the spongiform neurodegeneration induced by a murine oncornavirus. Askovic, S., Favara, C., McAtee, F.J., Portis, J.L. J. Virol. (2001) [Pubmed]
  39. Dissociation of thermoregulation in cats with cytotoxic pontine lesions. Amini-Sereshki, L. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  40. Excitability changes and glucose metabolism in experimentally induced focal cortical dysplasias. Redecker, C., Lutzenburg, M., Gressens, P., Evrard, P., Witte, O.W., Hagemann, G. Cereb. Cortex (1998) [Pubmed]
  41. Intralaminar thalamic nuclei lesions: widespread impact on dopamine denervation-mediated cellular defects in the rat basal ganglia. Bacci, J.J., Kachidian, P., Kerkerian-Le Goff, L., Salin, P. J. Neuropathol. Exp. Neurol. (2004) [Pubmed]
  42. Hippocampal theta rhythm in behaving rats following ibotenic acid lesion of the septum. Leung, L.S., Martin, L.A., Stewart, D.J. Hippocampus. (1994) [Pubmed]
WikiGenes - Universities