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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

TGF-beta 3 inhibits the increased gene expressions of pulmonary surfactant proteins induced by dexamethasone in fetal rat lung in vitro.

OBJECTIVE: To determine the effects of transforming growth factor-beta 3 (TGF-beta 3) on expressions of surfactant proteins (SPs). METHODS: Northern blot hybridization and reverse transcriptase polymerase chain reaction (RT-PCR) were employed to determine the SP-A, SP-B and SP-C mRNA levels of cultured lung explants and type II cells from fetal rat lungs. RESULTS: TGF-beta 3 alone did not affect the expressions of SPs either in explants or in type II cells. However, TGF-beta 3 did inhibit the increase of SP-B, SP-C mRNA levels caused by dexamethasone (100 nmol/L), in a dose-dependent manner. Furthermore, TGF-beta 3 had no direct inhibition on the increase of SP-B, SP-C mRNA induced by dexamethasone in type II cells, but had an indirect inhibitory effect mediated by fibroblasts. CONCLUSION: TGF-beta 3 plays an important inhibitory role in the development of pulmonary surfactant proteins. The present study may provide a possible explanation for the unideal effect of glucocorticoids in the prevention of neonatal respiratory distress syndrome.[1]


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