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Gene Review

Sftpb  -  surfactant protein B

Rattus norvegicus

Synonyms: Pulmonary surfactant-associated protein B, Pulmonary surfactant-associated proteolipid SPL(Phe), SP-B, Sftp3
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Disease relevance of Sftpb

  • We constructed replication-deficient, recombinant adenovirus vectors in which a constitutive viral promoter drives the expression of the DNAs for the surfactant-associated proteins, SP-B (AdCMV.SP-B) and SP-A (AdCMV.SP-A) [1].
  • Lung surfactant protein (SP)-A, SP-B, SP-C, and SP-D mRNA expressions were similar between control and IUGR rats [2].
  • CONCLUSION: T3 attenuated sepsis-induced surfactant dysfunction and SP-A and SP-B transcriptional changes during sepsis [3].
  • CONCLUSION: In this acute lung injury model, the effects of replacement therapy with surfactant consisting of synthetic phospholipids, SP-B and SP-C, were the same as those observed with MNS [4].
  • These findings indicate that the decrease in SP-B and SP-C mRNA in fetuses of STZ-DB rats may be, in part, due to a direct effect of hyperglycemia, whereas the decrease in SP-A mRNA content in STZ-DB rats appears to be due to other effects of diabetes in pregnancy [5].

High impact information on Sftpb

  • Furthermore, the data imply that the difference between plain PL surfactant preparations and bovine-derived surfactant preparations containing both SP-B and SP-C can be overcome by addition of SP-C [6].
  • In addition, electron micrographs reveal the formation of tubular myelin structures from in vitro preparations using SP-B(9-36) in place of porcine SP-B indicating that the peptide has the potential to mimic this property of the native protein [7].
  • In newborn rats exposed to hyperoxia on Days 3 through 10 of life, lung messenger RNAs (mRNAs) for SP-A and SP-B gradually and progressively increased, relative to levels in age-matched, air-exposed newborns, over this 8-d period [8].
  • Corresponding increases in protein binding to the SP-B promoter were demonstrated by gel shift analysis [9].
  • HNF-3 and TTF-1 transcription factors are known to stimulate SP-B transcription [9].

Biological context of Sftpb


Anatomical context of Sftpb

  • In contrast, in bronchiolar epithelial cells of diabetic lungs, the relative abundance of silver grains for SP-A mRNA increased approximately 2-fold above controls, while SP-B mRNA decreased slightly [14].
  • The abundance of mRNAs for SP-B and SP-C also increased in day-17 fetuses after either 1 or 3 d of DEX treatment.(ABSTRACT TRUNCATED AT 250 WORDS)[15]
  • Type II cells that were co-cultured with lung fibroblasts showed significant increases in messenger RNA (mRNA) levels of surfactant protein (SP)-A, SP-B, SP-C, and SP-D [16].
  • Tissue in situ hybridization showed that dexamethasone stimulated the levels of SP-B mRNA in cells from both the alveolar and bronchiolar epithelium [17].
  • NO production by alveolar macrophages, that the effect is due to a reduction in iNOS protein levels, and that the surfactant component responsible for the reduction is SP-B [18].

Associations of Sftpb with chemical compounds


Physical interactions of Sftpb

  • Footprinting analysis indicated that SP-A-induced protein binding to SP-B promoter was greater in amount, but not different in location, from that seen in control cells, which normally transcribe SP-B [9].

Regulatory relationships of Sftpb

  • In this report, we have examined the hormonal regulation of the rat surfactant protein B (SP-B) mRNA to determine whether SP-B expression is coordinately regulated with the surfactant phospholipids or with SP-A [17].
  • However, TGF-beta 3 did inhibit the increase of SP-B, SP-C mRNA levels caused by dexamethasone (100 nmol/L), in a dose-dependent manner [22].

Other interactions of Sftpb

  • Regulation of SP-B and SP-C secretion in rat type II cells in primary culture [19].
  • CONCLUSIONS: The effects of nitrofen in fetal rat lungs are reversed in part by antioxidant vitamins by upregulating the expression of TTF-1, HNF-3beta, and SP-B [23].
  • This pattern of SP-D mRNA expression was compared with the expression of the other surfactant proteins and found to be most similar to that of SP-B [24].
  • Examined by nuclear run-on assays, mechanical distention caused changes in transcriptional rates of RTI 40, SP-B, and SP-C [25].
  • Furthermore, TGF-beta 3 had no direct inhibition on the increase of SP-B, SP-C mRNA induced by dexamethasone in type II cells, but had an indirect inhibitory effect mediated by fibroblasts [22].

Analytical, diagnostic and therapeutic context of Sftpb


  1. In vitro and in vivo transfer and expression of human surfactant SP-A- and SP-B-associated protein cDNAs mediated by replication-deficient, recombinant adenoviral vectors. Korst, R.J., Bewig, B., Crystal, R.G. Hum. Gene Ther. (1995) [Pubmed]
  2. Effects of maternal undernutrition during late gestation on the lung surfactant system and morphometry in rats. Chen, C.M., Wang, L.F., Su, B. Pediatr. Res. (2004) [Pubmed]
  3. Effect of thyroid hormone (T3)-responsive changes in surfactant apoproteins on surfactant function during sepsis. Raafat, A.M., Franko, A.P., Zafar, R., Dulchavsky, S.A., Diebel, L.N., Ksenzenko, S. The Journal of trauma. (1997) [Pubmed]
  4. Modified natural and synthetically reconstituted surfactant therapies for acute lung injury caused by endotoxin in rats. Tashiro, K., Nishizuka, K., Matsumoto, Y., Ohta, K., Suzuki, Y., Kobayashi, T. Acta anaesthesiologica Scandinavica. (1999) [Pubmed]
  5. Glucose decreases steady state mRNA content of hydrophobic surfactant proteins B and C in fetal rat lung explants. Rayani, H.H., Gewolb, I.H., Floros, J. Exp. Lung Res. (1999) [Pubmed]
  6. Effects of rSP-C surfactant on oxygenation and histology in a rat-lung-lavage model of acute lung injury. Häfner, D., Germann, P.G., Hauschke, D. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  7. Location of structural transitions in an isotopically labeled lung surfactant SP-B peptide by IRRAS. Flach, C.R., Cai, P., Dieudonné, D., Brauner, J.W., Keough, K.M., Stewart, J., Mendelsohn, R. Biophys. J. (2003) [Pubmed]
  8. Elevated expression of surfactant proteins in newborn rats during adaptation to hyperoxia. White, C.W., Greene, K.E., Allen, C.B., Shannon, J.M. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
  9. Activation of surfactant protein-B transcription: signaling through the SP-A receptor utilizing the PI3 kinase pathway. Strayer, D.S., Korutla, L. J. Cell. Physiol. (2000) [Pubmed]
  10. Delayed hydrophobic surfactant protein (SP-B, SP-C) expression in fetuses of streptozotocin-treated rats. Guttentag, S.H., Phelps, D.S., Warshaw, J.B., Floros, J. Am. J. Respir. Cell Mol. Biol. (1992) [Pubmed]
  11. Maintenance of surfactant protein A and D secretion by rat alveolar type II cells in vitro. Mason, R.J., Lewis, M.C., Edeen, K.E., McCormick-Shannon, K., Nielsen, L.D., Shannon, J.M. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
  12. Respiratory distress after intratracheal bleomycin: selective deficiency of surfactant proteins B and C. Savani, R.C., Godinez, R.I., Godinez, M.H., Wentz, E., Zaman, A., Cui, Z., Pooler, P.M., Guttentag, S.H., Beers, M.F., Gonzales, L.W., Ballard, P.L. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  13. Overexpression of surfactant protein SP-A, SP-B, and SP-C mRNA in rat lungs with lipopolysaccharide-induced injury. Sugahara, K., Iyama, K., Sano, K., Kuroki, Y., Akino, T., Matsumoto, M. Lab. Invest. (1996) [Pubmed]
  14. Differential expressions of surfactant protein SP-A, SP-B, and SP-C mRNAs in rats with streptozotocin-induced diabetes demonstrated by in situ hybridization. Sugahara, K., Iyama, K., Sano, K., Morioka, T. Am. J. Respir. Cell Mol. Biol. (1994) [Pubmed]
  15. Effects of maternal dexamethasone on expression of SP-A, SP-B, and SP-C in the fetal rat lung. Schellhase, D.E., Shannon, J.M. Am. J. Respir. Cell Mol. Biol. (1991) [Pubmed]
  16. Lung fibroblasts improve differentiation of rat type II cells in primary culture. Shannon, J.M., Pan, T., Nielsen, L.D., Edeen, K.E., Mason, R.J. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
  17. Hormonal effects on the surfactant protein B (SP-B) mRNA in cultured fetal rat lung. Floros, J., Gross, I., Nichols, K.V., Veletza, S.V., Dynia, D., Lu, H.W., Wilson, C.M., Peterec, S.M. Am. J. Respir. Cell Mol. Biol. (1991) [Pubmed]
  18. Pulmonary surfactant inhibits LPS-induced nitric oxide production by alveolar macrophages. Miles, P.R., Bowman, L., Rao, K.M., Baatz, J.E., Huffman, L. Am. J. Physiol. (1999) [Pubmed]
  19. Regulation of SP-B and SP-C secretion in rat type II cells in primary culture. Gobran, L.I., Rooney, S.A. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  20. Spatial and temporal expression of surfactant proteins in hyperoxia-induced neonatal rat lung injury. ter Horst, S.A., Fijlstra, M., Sengupta, S., Walther, F.J., Wagenaar, G.T. BMC pulmonary medicine [electronic resource]. (2006) [Pubmed]
  21. Retinoic acid induces changes in the pattern of airway branching and alters epithelial cell differentiation in the developing lung in vitro. Cardoso, W.V., Williams, M.C., Mitsialis, S.A., Joyce-Brady, M., Rishi, A.K., Brody, J.S. Am. J. Respir. Cell Mol. Biol. (1995) [Pubmed]
  22. TGF-beta 3 inhibits the increased gene expressions of pulmonary surfactant proteins induced by dexamethasone in fetal rat lung in vitro. Wang, X., Jin, Q., Xu, J., Shen, W., Wang, J., Post, M. Chin. Med. J. (1997) [Pubmed]
  23. Effects of antioxidant vitamins on molecular regulators involved in lung hypoplasia induced by nitrofen. Gonzalez-Reyes, S., Martinez, L., Martinez-Calonge, W., Fernandez-Dumont, V., Tovar, J.A. J. Pediatr. Surg. (2006) [Pubmed]
  24. Regulation of surfactant protein D expression by glucocorticoids in vitro and in vivo. Deterding, R.R., Shimizu, H., Fisher, J.H., Shannon, J.M. Am. J. Respir. Cell Mol. Biol. (1994) [Pubmed]
  25. Mechanical distention modulates alveolar epithelial cell phenotypic expression by transcriptional regulation. Gutierrez, J.A., Ertsey, R., Scavo, L.M., Collins, E., Dobbs, L.G. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  26. Expression of surfactant proteins in embryonic rat lung. Wang, J., Souza, P., Kuliszewski, M., Tanswell, A.K., Post, M. Am. J. Respir. Cell Mol. Biol. (1994) [Pubmed]
  27. Alteration of pulmonary surfactant proteins in rats chronically exposed to cigarette smoke. Subramaniam, S., Whitsett, J.A., Hull, W., Gairola, C.G. Toxicol. Appl. Pharmacol. (1996) [Pubmed]
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