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Gene Review

Sftpc  -  surfactant protein C

Rattus norvegicus

Synonyms: Pulmonary surfactant-associated protein C, Pulmonary surfactant-associated proteolipid SPL(Val), SP-C, Sftp2
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Disease relevance of Sftpc

  • CONCLUSION: In this acute lung injury model, the effects of replacement therapy with surfactant consisting of synthetic phospholipids, SP-B and SP-C, were the same as those observed with MNS [1].
  • The effects of the surfactant proteins (SP)-A, SP-B, and SP-C on binding and endocytosis of fluorescently labeled lipid vesicles were studied in rat type II epithelial cells and in MLE-12 cells, a pulmonary adenocarcinoma cell line with alveolar cell characteristics [2].

High impact information on Sftpc

  • In a perfused rat lung model labeled with [35S]cysteine/methionine, immunoprecipitation of lung homogenate and lamellar body fractions identified early appearances of 35S-labeled 21-, 18-, and 16-kDa SP-C forms in homogenate and a 16-kDa intermediate form in lamellar bodies [3].
  • Furthermore, the data imply that the difference between plain PL surfactant preparations and bovine-derived surfactant preparations containing both SP-B and SP-C can be overcome by addition of SP-C [4].
  • We have tested two surfactant preparations with the same phospholipid (PL) composition, containing recombinant surfactant protein-C (rSP-C surfactant) and without SP-C (plain PL surfactant) [4].
  • Continuous contraction of culture membrane surface area by 25% for a duration of 4 h resulted in an 83% increase in SP-A, a 42% increase in SP-B, and a 230% increase in SP-C, in comparison with controls [5].
  • By contrast, SP-C and SP-D mRNAs were maximally increased relative to values in simultaneously air-exposed control rats after 4 d of exposure [6].

Biological context of Sftpc

  • Although the lipid and hydrophobic protein components of surfactant are believed to be secreted together by exocytosis of lamellar body contents, regulation of surfactant protein (SP) B and SP-C secretion has not previously been examined [7].
  • In fetal lungs from the STZ group, SP-B and SP-C mRNA also showed an increase with advancing gestational age, but the levels were decreased compared with controls at fetal days 18, 20, and 21 (P less than 0.05) [8].
  • In contrast, mechanical distention resulted in a decrease in mRNA content of two markers of the type II cell phenotype, surfactant protein (SP)-B and SP-C [9].
  • We conclude that respiratory distress after bleomycin in rats results from surfactant dysfunction in part secondary to selective downregulation of SP-B and SP-C [10].
  • Incorporation of SP-C in lipid vesicles markedly stimulated binding to the cell membrane at 4 degrees C and endocytosis of lipids at 37 degrees C. SP-C enhanced lipid uptake in MLE-12 cells, type II cells, and NIH 3T3 cells [2].

Anatomical context of Sftpc

  • Moreover, the number of silver grains representing SP-C mRNA decreased in alveolar type II cells from diabetic lungs compared with controls, and no silver grains for SP-C mRNA were present in bronchiolar epithelial cells from either control or diabetic groups [11].
  • Type II cells that were co-cultured with lung fibroblasts showed significant increases in messenger RNA (mRNA) levels of surfactant protein (SP)-A, SP-B, SP-C, and SP-D [12].
  • The abundance of mRNAs for SP-B and SP-C also increased in day-17 fetuses after either 1 or 3 d of DEX treatment.(ABSTRACT TRUNCATED AT 250 WORDS)[13]
  • Type II cells cultured on EHS matrix in D-GM had a decreased abundance of mRNAs for SP-A and SP-C than cells cultured on EHS matrix in D-5 as determined by Northern analysis [14].
  • Disruption of either microfilaments or microtubules significantly affected the half-lives of mRNAs for SP-A, SP-B, and SP-C [15].

Associations of Sftpc with chemical compounds

  • To address the question of whether secretion of SP-B and SP-C is stimulated by the same agonists that stimulate phospholipid secretion, we measured secretion of all four SPs under the same conditions used to measure phosphatidylcholine secretion [7].
  • Secretion of SP-B and SP-C was stimulated three- to fivefold by terbutaline, 5'-(N-ethylcarboxyamido)adenosine, ATP, 12-O-tetradecanoylphorbol 13-acetate, and ionomycin [7].
  • Delayed hydrophobic surfactant protein (SP-B, SP-C) expression in fetuses of streptozotocin-treated rats [8].
  • Effects of maternal dexamethasone on expression of SP-A, SP-B, and SP-C in the fetal rat lung [13].
  • In addition, the stretch- and glucocorticoid-induced alterations in tropoelastin and SP-C mRNA expression were abrogated with 10 microg/ml actinomycin D [16].

Regulatory relationships of Sftpc


Other interactions of Sftpc


Analytical, diagnostic and therapeutic context of Sftpc


  1. Modified natural and synthetically reconstituted surfactant therapies for acute lung injury caused by endotoxin in rats. Tashiro, K., Nishizuka, K., Matsumoto, Y., Ohta, K., Suzuki, Y., Kobayashi, T. Acta anaesthesiologica Scandinavica. (1999) [Pubmed]
  2. Roles of SP-A, SP-B, and SP-C in modulation of lipid uptake by pulmonary epithelial cells in vitro. Horowitz, A.D., Moussavian, B., Whitsett, J.A. Am. J. Physiol. (1996) [Pubmed]
  3. Localization, synthesis, and processing of surfactant protein SP-C in rat lung analyzed by epitope-specific antipeptide antibodies. Beers, M.F., Kim, C.Y., Dodia, C., Fisher, A.B. J. Biol. Chem. (1994) [Pubmed]
  4. Effects of rSP-C surfactant on oxygenation and histology in a rat-lung-lavage model of acute lung injury. Häfner, D., Germann, P.G., Hauschke, D. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  5. Continuous mechanical contraction modulates expression of alveolar epithelial cell phenotype. Gutierrez, J.A., Suzara, V.V., Dobbs, L.G. Am. J. Respir. Cell Mol. Biol. (2003) [Pubmed]
  6. Elevated expression of surfactant proteins in newborn rats during adaptation to hyperoxia. White, C.W., Greene, K.E., Allen, C.B., Shannon, J.M. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
  7. Regulation of SP-B and SP-C secretion in rat type II cells in primary culture. Gobran, L.I., Rooney, S.A. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  8. Delayed hydrophobic surfactant protein (SP-B, SP-C) expression in fetuses of streptozotocin-treated rats. Guttentag, S.H., Phelps, D.S., Warshaw, J.B., Floros, J. Am. J. Respir. Cell Mol. Biol. (1992) [Pubmed]
  9. Mechanical distention modulates alveolar epithelial cell phenotypic expression by transcriptional regulation. Gutierrez, J.A., Ertsey, R., Scavo, L.M., Collins, E., Dobbs, L.G. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  10. Respiratory distress after intratracheal bleomycin: selective deficiency of surfactant proteins B and C. Savani, R.C., Godinez, R.I., Godinez, M.H., Wentz, E., Zaman, A., Cui, Z., Pooler, P.M., Guttentag, S.H., Beers, M.F., Gonzales, L.W., Ballard, P.L. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  11. Differential expressions of surfactant protein SP-A, SP-B, and SP-C mRNAs in rats with streptozotocin-induced diabetes demonstrated by in situ hybridization. Sugahara, K., Iyama, K., Sano, K., Morioka, T. Am. J. Respir. Cell Mol. Biol. (1994) [Pubmed]
  12. Lung fibroblasts improve differentiation of rat type II cells in primary culture. Shannon, J.M., Pan, T., Nielsen, L.D., Edeen, K.E., Mason, R.J. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
  13. Effects of maternal dexamethasone on expression of SP-A, SP-B, and SP-C in the fetal rat lung. Schellhase, D.E., Shannon, J.M. Am. J. Respir. Cell Mol. Biol. (1991) [Pubmed]
  14. Effects of soluble factors and extracellular matrix on DNA synthesis and surfactant gene expression in primary cultures of rat alveolar type II cells. Sugahara, K., Mason, R.J., Shannon, J.M. Cell Tissue Res. (1998) [Pubmed]
  15. Influence of the cytoskeleton on surfactant protein gene expression in cultured rat alveolar type II cells. Shannon, J.M., Pan, T., Edeen, K.E., Nielsen, L.D. Am. J. Physiol. (1998) [Pubmed]
  16. Mechanical strain and dexamethasone selectively increase surfactant protein C and tropoelastin gene expression. Nakamura, T., Liu, M., Mourgeon, E., Slutsky, A., Post, M. Am. J. Physiol. Lung Cell Mol. Physiol. (2000) [Pubmed]
  17. Association of surfactant protein C with isolated alveolar type II cells. Pinto, R.A., Hawgood, S., Clements, J.A., Benson, B.J., Naidu, A., Hamilton, R.L., Wright, J.R. Biochim. Biophys. Acta (1995) [Pubmed]
  18. Entactin expression by rat lung and rat alveolar epithelial cells. Senior, R.M., Griffin, G.L., Mudd, M.S., Moxley, M.A., Longmore, W.J., Pierce, R.A. Am. J. Respir. Cell Mol. Biol. (1996) [Pubmed]
  19. Spatial and temporal expression of surfactant proteins in hyperoxia-induced neonatal rat lung injury. ter Horst, S.A., Fijlstra, M., Sengupta, S., Walther, F.J., Wagenaar, G.T. BMC pulmonary medicine [electronic resource]. (2006) [Pubmed]
  20. Surfactant protein C is expressed in alveolar type II cells but not in Clara cells of rat lung. Kalina, M., Mason, R.J., Shannon, J.M. Am. J. Respir. Cell Mol. Biol. (1992) [Pubmed]
  21. Expression of surfactant proteins in embryonic rat lung. Wang, J., Souza, P., Kuliszewski, M., Tanswell, A.K., Post, M. Am. J. Respir. Cell Mol. Biol. (1994) [Pubmed]
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