- Recombinant human megakaryocyte growth and development factor (MGDF) increases the numbers of megakaryocyte progenitor cells to normal values in long-term bone marrow cultures of patients with AML in first remission. Kasper, C., Schwarzer, A., De Wynter, E.A., Chang, J., Dexter, T.M., Ryder, D., Testa, N.G. Leukemia (1998)