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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Transplantation, Autologous

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Disease relevance of Transplantation, Autologous


Psychiatry related information on Transplantation, Autologous

  • Utilization of FITC-QBEND10 instead of FICT-8G12 to estimate infrequent (usually less than or equal to 5%) CD34+ CHP for clinical decision-making in autologous transplantation of CHP exposes clinicians to the risk of either overestimating (false positive) or underestimating (false negative) these cells in peripheral blood [6].

High impact information on Transplantation, Autologous

  • Persistent hyperparathyroidism caused by incomplete parathyroid resection and a hyperfunctioning parathyroid autograft [2].
  • Therefore, we studied the temporo-spatial expression of transglutaminase activity in skin regenerating from cultured epithelial autografts in severely burned children by the specific incorporation of monodansylcadaverine into cryostat sections from skin biopsies obtained between 5 d to 17 mo after grafting [7].
  • Cross-linking of the dermo-epidermal junction of skin regenerating from keratinocyte autografts. Anchoring fibrils are a target for tissue transglutaminase [7].
  • Four patients had forearm autografts of parathyroid tissue that appeared to be functioning at very low rates according to paired venous sampling, and all five patients had relatively low circulating concentrations of parathyroid hormone [8].
  • Venoarterial autografts (N = 192) were implanted in 48 hypercholesterolemic dogs divided into six groups: group A, control; B, FO (as MaxEPA, 200 mg/kg/day eicosapentaenoic acid); C, aspirin (ASA, 50 mg/kg/day); D, TX synthetase inhibitor (TXSI [CGS-12970], 10 mg/kg/day); E, FO + ASA; and F, FO + TXSI [9].

Chemical compound and disease context of Transplantation, Autologous


Biological context of Transplantation, Autologous


Anatomical context of Transplantation, Autologous


Associations of Transplantation, Autologous with chemical compounds

  • High-dose melphalan followed by autologous transplantation appears effective for improving the symptoms and systemic manifestations of scleromyxedema [25].
  • A combined immunochemotherapy protocol using a cocktail of two immunotoxins directed against CD5/Tp67 and CD7/Tp41 T-lineage differentiation antigens in combination with the in vitro active cyclophosphamide congener 4-hydroperoxy-cyclophosphamide (4-HC) was used to purge autografts [26].
  • The venous autograft exhibited a reversible reduction in myosin content and in maximum contractile response (force/cross-sectional area) to potassium chloride and norepinephrine [27].
  • A monoclonal antibody (MoAb) cocktail of BA-1, BA-2, and BA-3 plus rabbit complement (C') plus 4-hydroperoxycyclophosphamide (4-HC) was used to eliminate residual occult leukemia cells from autografts [28].
  • Detection of neo-marked marrow cells almost 2 years after autologous transplantation in a large mammalian species shows that retroviral infection of marrow cells in LTMCs is a potentially nontoxic and efficient protocol for gene transfer [29].

Gene context of Transplantation, Autologous

  • These results were confirmed in an analysis of 186 patients randomized to receive or not receive an autograft in first CR and in a donor-versus-no donor analysis of 683 patients to assess the role of allograft (for latter, FLT3/ITD(-) OR = 0.70, CIs = 0.53-0.92; FLT3/ITD(+) OR = 0.59, CIs = 0.40-0.87; test for interaction, P = .5) [30].
  • This is the second report of an APL patient who was transplanted in molecular remission with a PML/RAR alpha-positive PBSC autograft [31].
  • We report the temporo-spatial expression of fibulin-2 in skin regenerating from keratinocyte autografts [32].
  • We therefore studied the in situ distribution of latent TGF binding protein-1 (LTBP-1) and latent TGF-beta1 on extracellular matrix elements of normal human skin and skin regenerating from cultured keratinocyte autografts [33].
  • Interleukin-2 and interferon-gamma mRNA showed maximal expression on POD 12, while in autografts, a marked decrease was observed after POD 3 [34].

Analytical, diagnostic and therapeutic context of Transplantation, Autologous


  1. Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implications. Kish, S.J., Shannak, K., Hornykiewicz, O. N. Engl. J. Med. (1988) [Pubmed]
  2. Persistent hyperparathyroidism caused by incomplete parathyroid resection and a hyperfunctioning parathyroid autograft. Spiegel, A.M., Downs, R.W., Santora, A., Marx, S.J., Doppman, J., Shull, J. JAMA (1983) [Pubmed]
  3. Recovery of chronic parkinsonian monkeys by autotransplants of carotid body cell aggregates into putamen. Luquin, M.R., Montoro, R.J., Guillén, J., Saldise, L., Insausti, R., Del Río, J., López-Barneo, J. Neuron (1999) [Pubmed]
  4. Superiority of thalidomide and dexamethasone over vincristine-doxorubicindexamethasone (VAD) as primary therapy in preparation for autologous transplantation for multiple myeloma. Cavo, M., Zamagni, E., Tosi, P., Tacchetti, P., Cellini, C., Cangini, D., de Vivo, A., Testoni, N., Nicci, C., Terragna, C., Grafone, T., Perrone, G., Ceccolini, M., Tura, S., Baccarani, M. Blood (2005) [Pubmed]
  5. Randomized trial of autologous filgrastim-primed bone marrow transplantation versus filgrastim-mobilized peripheral blood stem cell transplantation in lymphoma patients. Damiani, D., Fanin, R., Silvestri, F., Grimaz, S., Infanti, L., Geromin, A., Cerno, M., Michieli, M., Rinaldi, C., Savignano, C., Trani, G., Fiacchini, M., Baccarani, M. Blood (1997) [Pubmed]
  6. Flow cytometry to estimate circulating hematopoietic progenitors for autologous transplantation: comparative analysis of different CD34 monoclonal antibodies. Siena, S., Bregni, M., Brando, B., Belli, N., Lansdorp, P.M., Bonadonna, G., Gianni, M. Haematologica (1991) [Pubmed]
  7. Cross-linking of the dermo-epidermal junction of skin regenerating from keratinocyte autografts. Anchoring fibrils are a target for tissue transglutaminase. Raghunath, M., Höpfner, B., Aeschlimann, D., Lüthi, U., Meuli, M., Altermatt, S., Gobet, R., Bruckner-Tuderman, L., Steinmann, B. J. Clin. Invest. (1996) [Pubmed]
  8. Osteomalacia after parathyroidectomy in patients with uremia. Felsenfeld, A.J., Harrelson, J.M., Gutman, R.A., Wells, S.A., Drezner, M.K. Ann. Intern. Med. (1982) [Pubmed]
  9. Mechanisms responsible for inhibition of vein-graft arteriosclerosis by fish oil. Sarris, G.E., Fann, J.I., Sokoloff, M.H., Smith, D.L., Loveday, M., Kosek, J.C., Stephens, R.J., Cooper, A.D., May, K., Willis, A.L. Circulation (1989) [Pubmed]
  10. Peripheral blood stem cell transplants for multiple myeloma: identification of favorable variables for rapid engraftment in 225 patients. Tricot, G., Jagannath, S., Vesole, D., Nelson, J., Tindle, S., Miller, L., Cheson, B., Crowley, J., Barlogie, B. Blood (1995) [Pubmed]
  11. Autologous transplantation of blood-derived hemopoietic stem cells after myeloablative therapy in a patient with Burkitt's lymphoma. Körbling, M., Dörken, B., Ho, A.D., Pezzutto, A., Hunstein, W., Fliedner, T.M. Blood (1986) [Pubmed]
  12. Therapy of acute phase chronic myelogenous leukemia with intensive chemotherapy, blood cell autotransplant and cyclosporine A. Carella, A.M., Gaozza, E., Raffo, M.R., Carlier, P., Frassoni, F., Valbonesi, M., Lercari, G., Sessarego, M., Defferrari, R., Guerrasio, A. Leukemia (1991) [Pubmed]
  13. Outcome assessment of age group-specific (+/- 50 years) post-remission consolidation with high-dose cytarabine or bone marrow autograft for adult acute myelogenous leukemia. Bassan, R., Raimondi, R., Lerede, T., D'emilio, A., Buelli, M., Borleri, G., Personeni, A., Bellavita, P., Rodeghiero, F., Barbui, T. Haematologica (1998) [Pubmed]
  14. Lymphomas as sequelae of the transplantation of CO2-treated skin autografts in mice. Goldsmith, A.E., Narvaez, R. Oncology (1975) [Pubmed]
  15. Extended survival in advanced and refractory multiple myeloma after single-agent thalidomide: identification of prognostic factors in a phase 2 study of 169 patients. Barlogie, B., Desikan, R., Eddlemon, P., Spencer, T., Zeldis, J., Munshi, N., Badros, A., Zangari, M., Anaissie, E., Epstein, J., Shaughnessy, J., Ayers, D., Spoon, D., Tricot, G. Blood (2001) [Pubmed]
  16. Pilot trial of interleukin-2 with granulocyte colony-stimulating factor for the mobilization of progenitor cells in advanced breast cancer patients undergoing high-dose chemotherapy: expansion of immune effectors within the stem-cell graft and post-stem-cell infusion. Sosman, J.A., Stiff, P., Moss, S.M., Sorokin, P., Martone, B., Bayer, R., van Besien, K., Devine, S., Stock, W., Peace, D., Chen, Y., Long, C., Gustin, D., Viana, M., Hoffman, R. J. Clin. Oncol. (2001) [Pubmed]
  17. Segmental small intestinal allografts. II. Inadequate function with cyclosporine immunosuppression: evidence of a protein-losing enteropathy. Collin, J., Dennison, A.R., Watkins, R.M., Millard, P.R., Morris, P.J. Transplantation (1987) [Pubmed]
  18. Pulsatile release of LH and secretion of ovarian steroids in sheep during the luteal phase of the estrous cycle. Baird, D.T., Swanston, I., Scaramuzzi, R.J. Endocrinology (1976) [Pubmed]
  19. Recombinant human megakaryocyte growth and development factor (MGDF) increases the numbers of megakaryocyte progenitor cells to normal values in long-term bone marrow cultures of patients with AML in first remission. Kasper, C., Schwarzer, A., De Wynter, E.A., Chang, J., Dexter, T.M., Ryder, D., Testa, N.G. Leukemia (1998) [Pubmed]
  20. Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation. Dunbar, C.E., Cottler-Fox, M., O'Shaughnessy, J.A., Doren, S., Carter, C., Berenson, R., Brown, S., Moen, R.C., Greenblatt, J., Stewart, F.M. Blood (1995) [Pubmed]
  21. Efficacy and costs of granulocyte colony-stimulating factor in allogeneic T-cell depleted bone marrow transplantation. Lee, S.J., Weller, E., Alyea, E.P., Ritz, J., Soiffer, R.J. Blood (1998) [Pubmed]
  22. An immunotoxin with therapeutic potential in T cell leukemia: WT1-ricin A. Myers, C.D., Thorpe, P.E., Ross, W.C., Cumber, A.J., Katz, F.E., Tax, W., Greaves, M.F. Blood (1984) [Pubmed]
  23. Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord. Lu, J., Féron, F., Mackay-Sim, A., Waite, P.M. Brain (2002) [Pubmed]
  24. Long-term patency of vein grafts preserved in liquid nitrogen in dimethyl sulfoxide. Weber, T.R., Lindenauer, S.M., Dent, T.L., Allen, E., Salles, C.A., Weatherbee, L. Ann. Surg. (1976) [Pubmed]
  25. Scleromyxedema: role of high-dose melphalan with autologous stem cell transplantation. Donato, M.L., Feasel, A.M., Weber, D.M., Prieto, V.G., Giralt, S.A., Champlin, R.E., Duvic, M. Blood (2006) [Pubmed]
  26. Autologous bone marrow transplantation in high-risk remission T-lineage acute lymphoblastic leukemia using immunotoxins plus 4-hydroperoxycyclophosphamide for marrow purging. Uckun, F.M., Kersey, J.H., Vallera, D.A., Ledbetter, J.A., Weisdorf, D., Myers, D.E., Haake, R., Ramsay, N.K. Blood (1990) [Pubmed]
  27. Adaptation of canine saphenous veins to grafting. Correlation of contractility and contractile protein content. Seidel, C.L., Lewis, R.M., Bowers, R., Bukoski, R.D., Kim, H.S., Allen, J.C., Hartley, C. Circ. Res. (1984) [Pubmed]
  28. Autologous bone marrow transplantation in high-risk remission B-lineage acute lymphoblastic leukemia using a cocktail of three monoclonal antibodies (BA-1/CD24, BA-2/CD9, and BA-3/CD10) plus complement and 4-hydroperoxycyclophosphamide for ex vivo bone marrow purging. Uckun, F.M., Kersey, J.H., Haake, R., Weisdorf, D., Ramsay, N.K. Blood (1992) [Pubmed]
  29. Autologous transplantation of canine long-term marrow culture cells genetically marked by retroviral vectors. Carter, R.F., Abrams-Ogg, A.C., Dick, J.E., Kruth, S.A., Valli, V.E., Kamel-Reid, S., Dubé, I.D. Blood (1992) [Pubmed]
  30. No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML10 and 12 trials. Gale, R.E., Hills, R., Kottaridis, P.D., Srirangan, S., Wheatley, K., Burnett, A.K., Linch, D.C. Blood (2005) [Pubmed]
  31. Prolonged molecular remission after PML/RAR alpha-positive autologous peripheral blood stem cell transplantation in acute promyelocytic leukemia: is relevant pretransplant minimal residual disease in the graft? Sanz, M.A., de la Rubia, J., Bonanad, S., Barragán, E., Sempere, A., Martín, G., Martínez, J.A., Jiménez, C., Cervera, J., Bolufer, P., Sanz, G.F. Leukemia (1998) [Pubmed]
  32. Confocal laser scanning analysis of the association of fibulin-2 with fibrillin-1 and fibronectin define different stages of skin regeneration. Raghunath, M., Tschödrich-Rotter, M., Sasaki, T., Meuli, M., Chu, M.L., Timpl, R. J. Invest. Dermatol. (1999) [Pubmed]
  33. The cutaneous microfibrillar apparatus contains latent transforming growth factor-beta binding protein-1 (LTBP-1) and is a repository for latent TGF-beta1. Raghunath, M., Unsöld, C., Kubitscheck, U., Bruckner-Tuderman, L., Peters, R., Meuli, M. J. Invest. Dermatol. (1998) [Pubmed]
  34. Cytokine mRNA expression during experimental corneal allograft rejection. Torres, P.F., De Vos, A.F., van der Gaag, R., Martins, B., Kijlstra, A. Exp. Eye Res. (1996) [Pubmed]
  35. Cyclin D1 overexpression is a favorable prognostic variable for newly diagnosed multiple myeloma patients treated with high-dose chemotherapy and single or double autologous transplantation. Soverini, S., Cavo, M., Cellini, C., Terragna, C., Zamagni, E., Ruggeri, D., Testoni, N., Tosi, P., De Vivo, A., Amabile, M., Grafone, T., Ottaviani, E., Giannini, B., Cangini, D., Bonifazi, F., Neri, A., Fabris, S., Tura, S., Baccarani, M., Martinelli, G. Blood (2003) [Pubmed]
  36. Factors affecting duration of survival after onset of blastic transformation of chronic myeloid leukemia. Wadhwa, J., Szydlo, R.M., Apperley, J.F., Chase, A., Bua, M., Marin, D., Olavarria, E., Kanfer, E., Goldman, J.M. Blood (2002) [Pubmed]
  37. Flow cytometry for clinical estimation of circulating hematopoietic progenitors for autologous transplantation in cancer patients. Siena, S., Bregni, M., Brando, B., Belli, N., Ravagnani, F., Gandola, L., Stern, A.C., Lansdorp, P.M., Bonadonna, G., Gianni, A.M. Blood (1991) [Pubmed]
  38. Comparable engraftment kinetics following peripheral-blood stem-cell infusion mobilized with granulocyte colony-stimulating factor with or without cyclophosphamide in multiple myeloma. Desikan, K.R., Barlogie, B., Jagannath, S., Vesole, D.H., Siegel, D., Fassas, A., Munshi, N., Singhal, S., Mehta, J., Tindle, S., Nelson, J., Bracy, D., Mattox, S., Tricot, G. J. Clin. Oncol. (1998) [Pubmed]
  39. Subtotal versus total parathyroidectomy with forearm autograft for secondary hyperparathyroidism in chronic renal failure. Takagi, H., Tominaga, Y., Uchida, K., Yamada, N., Kawai, M., Kano, T., Morimoto, T. Ann. Surg. (1984) [Pubmed]
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