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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Thrombopoiesis


High impact information on Thrombopoiesis


Chemical compound and disease context of Thrombopoiesis


Biological context of Thrombopoiesis


Anatomical context of Thrombopoiesis


Associations of Thrombopoiesis with chemical compounds

  • In view of previous reports on the effect of acetylcholine analogs and ChoEase inhibitors in the induction of megakaryocytopoiesis and production of platelets in the mouse, we further searched for such phenomena in nonleukemic patients with platelet production disorders [24].
  • These results provide in vivo insights into the structural elements of the GP Ibalpha subunit that contribute to normal megakaryocyte maturation and thrombopoiesis [25].
  • Therefore, these data show that the novel tyrosine kinase phosphatase PTP-RO is involved in megakaryocytopoiesis and that its function is mediated by the SCF/c-Kit pathway [26].
  • They may be responsible for the enhanced megakaryocytopoiesis seen in the marrow of mice 7 days after the injection of 5-FU [27].
  • Lithium enhancement of megakaryocytopoiesis in culture: mediation via accessory marrow cells [28].

Gene context of Thrombopoiesis


Analytical, diagnostic and therapeutic context of Thrombopoiesis


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  3. TXAS-deleted mice exhibit normal thrombopoiesis, defective hemostasis, and resistance to arachidonate-induced death. Yu, I.S., Lin, S.R., Huang, C.C., Tseng, H.Y., Huang, P.H., Shi, G.Y., Wu, H.L., Tang, C.L., Chu, P.H., Wang, L.H., Wu, K.K., Lin, S.W. Blood (2004) [Pubmed]
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  7. cMpl ligand is a humoral regulator of megakaryocytopoiesis. Wendling, F., Maraskovsky, E., Debili, N., Florindo, C., Teepe, M., Titeux, M., Methia, N., Breton-Gorius, J., Cosman, D., Vainchenker, W. Nature (1994) [Pubmed]
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  12. A phase II double-blind randomized study of the simultaneous administration of recombinant human interleukin-6 and recombinant human granulocyte colony-stimulating factor following paclitaxel and carboplatin chemotherapy in patients with advanced epithelial ovarian cancer. Hochster, H., Speyer, J.L., Mandeli, J.P., Runowicz, C., Wadler, S., Berk, G., Wallach, R., Holland, J.F. Gynecol. Oncol. (1999) [Pubmed]
  13. The role of transforming growth factor-beta in PEG-rHuMGDF-induced reversible myelofibrosis in rats. Yanagida, M., Ide, Y., Imai, A., Toriyama, M., Aoki, T., Harada, K., Izumi, H., Uzumaki, H., Kusaka, M., Tokiwa, T. Br. J. Haematol. (1997) [Pubmed]
  14. Platelet production, clearance and distribution in patients with idiopathic thrombocytopenic purpura. Isaka, Y., Kambayashi, J., Kimura, K., Matsumoto, M., Uehara, A., Hashikawa, K., Kamada, T., Imaizumi, M., Ashida, K., Nakayama, H. Thromb. Res. (1990) [Pubmed]
  15. Tyrosine-599 of the c-Mpl receptor is required for Shc phosphorylation and the induction of cellular differentiation. Alexander, W.S., Maurer, A.B., Novak, U., Harrison-Smith, M. EMBO J. (1996) [Pubmed]
  16. Integrin alphaIIb promoter-targeted expression of gene products in megakaryocytes derived from retrovirus-transduced human hematopoietic cells. Wilcox, D.A., Olsen, J.C., Ishizawa, L., Griffith, M., White, G.C. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  17. Both megakaryocytopoiesis and erythropoiesis are induced in mice infected with a retrovirus expressing an oncogenic erythropoietin receptor. Longmore, G.D., Pharr, P., Neumann, D., Lodish, H.F. Blood (1993) [Pubmed]
  18. Markedly reduced expression of platelet c-mpl receptor in essential thrombocythemia. Horikawa, Y., Matsumura, I., Hashimoto, K., Shiraga, M., Kosugi, S., Tadokoro, S., Kato, T., Miyazaki, H., Tomiyama, Y., Kurata, Y., Matsuzawa, Y., Kanakura, Y. Blood (1997) [Pubmed]
  19. Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice. Hokom, M.M., Lacey, D., Kinstler, O.B., Choi, E., Kaufman, S., Faust, J., Rowan, C., Dwyer, E., Nichol, J.L., Grasel, T., Wilson, J., Steinbrink, R., Hecht, R., Winters, D., Boone, T., Hunt, P. Blood (1995) [Pubmed]
  20. Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Alexander, W.S., Roberts, A.W., Nicola, N.A., Li, R., Metcalf, D. Blood (1996) [Pubmed]
  21. Thrombopoietin is synthesized by bone marrow stromal cells. Guerriero, A., Worford, L., Holland, H.K., Guo, G.R., Sheehan, K., Waller, E.K. Blood (1997) [Pubmed]
  22. Identification of a family of alternatively spliced mRNA species of angiopoietin-1. Huang, Y.Q., Li, J.J., Karpatkin, S. Blood (2000) [Pubmed]
  23. Hematopoietic-specific beta 1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2. Lecine, P., Italiano, J.E., Kim, S.W., Villeval, J.L., Shivdasani, R.A. Blood (2000) [Pubmed]
  24. Coamplification of human acetylcholinesterase and butyrylcholinesterase genes in blood cells: correlation with various leukemias and abnormal megakaryocytopoiesis. Lapidot-Lifson, Y., Prody, C.A., Ginzberg, D., Meytes, D., Zakut, H., Soreq, H. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  25. Amelioration of the macrothrombocytopenia associated with the murine Bernard-Soulier syndrome. Kanaji, T., Russell, S., Ware, J. Blood (2002) [Pubmed]
  26. The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor. Taniguchi, Y., London, R., Schinkmann, K., Jiang, S., Avraham, H. Blood (1999) [Pubmed]
  27. Characterization of megakaryocyte spleen colony-forming units by response to 5-fluorouracil and by unit gravity sedimentation. Thean, L.E., Hodgson, G.S., Bertoncello, I., Radley, J.M. Blood (1983) [Pubmed]
  28. Lithium enhancement of megakaryocytopoiesis in culture: mediation via accessory marrow cells. Chatelain, C., Burstein, S.A., Harker, L.A. Blood (1983) [Pubmed]
  29. Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets. Rocca, B., Secchiero, P., Ciabattoni, G., Ranelletti, F.O., Catani, L., Guidotti, L., Melloni, E., Maggiano, N., Zauli, G., Patrono, C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  30. Modulation of megakaryocytopoiesis by thrombopoietin: the c-Mpl ligand. Banu, N., Wang, J.F., Deng, B., Groopman, J.E., Avraham, H. Blood (1995) [Pubmed]
  31. Regulation of interleukin-11 protein and mRNA expression in neonatal and adult fibroblasts and endothelial cells. Suen, Y., Chang, M., Lee, S.M., Buzby, J.S., Cairo, M.S. Blood (1994) [Pubmed]
  32. Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor. Basser, R.L., O'Flaherty, E., Green, M., Edmonds, M., Nichol, J., Menchaca, D.M., Cohen, B., Begley, C.G. Blood (2002) [Pubmed]
  33. Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene. Metcalf, D., Carpinelli, M.R., Hyland, C., Mifsud, S., Dirago, L., Nicola, N.A., Hilton, D.J., Alexander, W.S. Blood (2005) [Pubmed]
  34. The influence of automated plateletpheresis on systemic levels of hematopoietic growth factors. Weisbach, V., Friedlein, H., Glaser, A., Zingsem, J., Zimmermann, R., Eckstein, R. Transfusion (1999) [Pubmed]
  35. Platelet c-mpl expression is dysregulated in patients with essential thrombocythaemia but this is not of diagnostic value. Harrison, C.N., Gale, R.E., Pezella, F., Mire-Sluis, A., MacHin, S.J., Linch, D.C. Br. J. Haematol. (1999) [Pubmed]
  36. Castration decreases thrombocytopoiesis and testosterone restores platelet production in castrated BALB/c mice: evidence that testosterone acts on a bipotential hematopoietic precursor cell. Sullivan, P.S., Jackson, C.W., McDonald, T.P. J. Lab. Clin. Med. (1995) [Pubmed]
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