The meiosis-specific Hop2 protein of S. cerevisiae ensures synapsis between homologous chromosomes.
The hop2 mutant of S. cerevisiae displays a novel phenotype: meiotic chromosomes form nearly wild-type amounts of synaptonemal complex, but most chromosomes are engaged in synapsis with nonhomologous partners. The meiosis-specific Hop2 protein localizes to chromosomes prior to and during synapsis and in the absence of the double-strand breaks that initiate recombination. hop2 strains sustain a wild-type level of meiotic double-strand breaks, but these breaks remain unrepaired. The hop2 mutant arrests at the pachytene stage of meiotic prophase with the RecA-like protein Dmc1 located at numerous sites along synapsed chromosomes. We propose that the Hop2 protein functions to prevent synapsis between nonhomologous chromosomes.[1]References
- The meiosis-specific Hop2 protein of S. cerevisiae ensures synapsis between homologous chromosomes. Leu, J.Y., Chua, P.R., Roeder, G.S. Cell (1998) [Pubmed]
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