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Gene Review

HOP2  -  Hop2p

Saccharomyces cerevisiae S288c

Synonyms: Homologous-pairing protein 2, YGL033W
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High impact information on HOP2


Biological context of HOP2


Physical interactions of HOP2

  • In Saccharomyces cerevisiae, the Hop2 protein forms a complex with the Mnd1 protein and is required for the alignment of homologous chromosomes during meiosis, probably through extensive homology matching between them [4].

Other interactions of HOP2

  • Biochemical studies indicate that Hop2 and Mnd1 proteins form a stable heterodimer with a higher affinity for double-stranded than single-stranded DNA, and that this heterodimer stimulates the strand assimilation activity of Dmc1 in vitro [5].
  • We conclude that Rad51 is capable of carrying out a homology search independently, whereas Dmc1 requires additional factors such as Hop2 [6].
  • HOP2 pre-mRNA is spliced efficiently in the absence of the Mer1 and Nam8 proteins, which are required for splicing the transcripts of two other meiosis-specific genes [3].


  1. The meiosis-specific Hop2 protein of S. cerevisiae ensures synapsis between homologous chromosomes. Leu, J.Y., Chua, P.R., Roeder, G.S. Cell (1998) [Pubmed]
  2. Mnd1/Hop2 facilitates Dmc1-dependent interhomolog crossover formation in meiosis of budding yeast. Henry, J.M., Camahort, R., Rice, D.A., Florens, L., Swanson, S.K., Washburn, M.P., Gerton, J.L. Mol. Cell. Biol. (2006) [Pubmed]
  3. Splicing of the meiosis-specific HOP2 transcript utilizes a unique 5' splice site. Leu, J.Y., Roeder, G.S. Mol. Cell. Biol. (1999) [Pubmed]
  4. Stimulation of DNA strand exchange by the human TBPIP/Hop2-Mnd1 complex. Enomoto, R., Kinebuchi, T., Sato, M., Yagi, H., Kurumizaka, H., Yokoyama, S. J. Biol. Chem. (2006) [Pubmed]
  5. Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homolog juxtaposition and strand assimilation. Chen, Y.K., Leng, C.H., Olivares, H., Lee, M.H., Chang, Y.C., Kung, W.M., Ti, S.C., Lo, Y.H., Wang, A.H., Chang, C.S., Bishop, D.K., Hsueh, Y.P., Wang, T.F. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  6. The importance of genetic recombination for fidelity of chromosome pairing in meiosis. Tsubouchi, H., Roeder, G.S. Dev. Cell (2003) [Pubmed]
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