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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Pachytene Stage

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Disease relevance of Pachytene Stage

  • The recombination frequencies (determined by the mean number of MLH1 foci per cell at the pachytene stage) were significantly reduced in obstructive azoospermia compared to that in controls [1].

High impact information on Pachytene Stage


Biological context of Pachytene Stage


Anatomical context of Pachytene Stage


Associations of Pachytene Stage with chemical compounds

  • Results are presented here which demonstrate that the rates of [14C]acetate incorporation into cholesterol and dolichol increased 4- to 5-fold as mouse spermatocytes matured from the preleptotene to prepuberal pachytene stages [14].

Gene context of Pachytene Stage

  • The ndt80 null and point mutants arrest at the pachytene stage of meiosis, with homologs connected by full-length synaptonemal complexes and spindle pole bodies duplicated but unseparated [15].
  • The number of MSH4 foci decreases gradually as pachynema progresses [16].
  • Cdk2 colocalizes with MLH1, a mismatch repair protein at sites of reciprocal recombination in mid-late pachynema [17].
  • During the leptotene to pachytene stages, PCNA and FEN-1 were localized in the nuclear region [18].
  • In the pachytene stage, the Rad51 protein was present almost exclusively along the core of the synaptonemal complexes (SC) [19].

Analytical, diagnostic and therapeutic context of Pachytene Stage


  1. Immunofluorescent synaptonemal complex analysis in azoospermic men. Sun, F., Greene, C., Turek, P.J., Ko, E., Rademaker, A., Martin, R.H. Cytogenet. Genome Res. (2005) [Pubmed]
  2. Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation. de Vries, F.A., de Boer, E., van den Bosch, M., Baarends, W.M., Ooms, M., Yuan, L., Liu, J.G., van Zeeland, A.A., Heyting, C., Pastink, A. Genes Dev. (2005) [Pubmed]
  3. MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Kneitz, B., Cohen, P.E., Avdievich, E., Zhu, L., Kane, M.F., Hou, H., Kolodner, R.D., Kucherlapati, R., Pollard, J.W., Edelmann, W. Genes Dev. (2000) [Pubmed]
  4. Localization of RecA-like recombination proteins on chromosomes of the lily at various meiotic stages. Terasawa, M., Shinohara, A., Hotta, Y., Ogawa, H., Ogawa, T. Genes Dev. (1995) [Pubmed]
  5. A human DAZ transgene confers partial rescue of the mouse Dazl null phenotype. Slee, R., Grimes, B., Speed, R.M., Taggart, M., Maguire, S.M., Ross, A., McGill, N.I., Saunders, P.T., Cooke, H.J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  6. Bloom's syndrome protein, BLM, colocalizes with replication protein A in meiotic prophase nuclei of mammalian spermatocytes. Walpita, D., Plug, A.W., Neff, N.F., German, J., Ashley, T. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  7. Gene disruption of a G4-DNA-dependent nuclease in yeast leads to cellular senescence and telomere shortening. Liu, Z., Lee, A., Gilbert, W. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  8. Functional role for the c-Abl tyrosine kinase in meiosis I. Kharbanda, S., Pandey, P., Morris, P.L., Whang, Y., Xu, Y., Sawant, S., Zhu, L.J., Kumar, N., Yuan, Z.M., Weichselbaum, R., Sawyers, C.L., Pandita, T.K., Kufe, D. Oncogene (1998) [Pubmed]
  9. Molecular characterization of a pericentric inversion in mouse chromosome 8 implicates telomeres as promoters of meiotic recombination. Ashley, T., Cacheiro, N.L., Russell, L.B., Ward, D.C. Chromosoma (1993) [Pubmed]
  10. Identification of functional domains in the Sep1 protein (= Kem1, Xrn1), which is required for transition through meiotic prophase in Saccharomyces cerevisiae. Bashkirov, V.I., Solinger, J.A., Heyer, W.D. Chromosoma (1995) [Pubmed]
  11. Unequal crossing over and heterochromatin exchange in the X-Y bivalents of the deer mouse, Peromyscus beatae. Sudman, P.D., Greenbaum, I.F. Chromosoma (1990) [Pubmed]
  12. Expression of a mouse zinc finger protein gene in both spermatocytes and oocytes during meiosis. Noce, T., Fujiwara, Y., Sezaki, M., Fujimoto, H., Higashinakagawa, T. Dev. Biol. (1992) [Pubmed]
  13. Micronuclei and chromosome aberrations in Xenopus laevis spermatocytes and spermatids exposed to adriamycin and colcemid. Risley, M.S., Pohorenec, G.M. Mutat. Res. (1991) [Pubmed]
  14. Elevated cholesterol and dolichol synthesis in mouse pachytene spermatocytes. Potter, J.E., Millette, C.F., James, M.J., Kandutsch, A.A. J. Biol. Chem. (1981) [Pubmed]
  15. NDT80, a meiosis-specific gene required for exit from pachytene in Saccharomyces cerevisiae. Xu, L., Ajimura, M., Padmore, R., Klein, C., Kleckner, N. Mol. Cell. Biol. (1995) [Pubmed]
  16. MSH4 acts in conjunction with MLH1 during mammalian meiosis. Santucci-Darmanin, S., Walpita, D., Lespinasse, F., Desnuelle, C., Ashley, T., Paquis-Flucklinger, V. FASEB J. (2000) [Pubmed]
  17. Localization of two mammalian cyclin dependent kinases during mammalian meiosis. Ashley, T., Walpita, D., de Rooij, D.G. J. Cell. Sci. (2001) [Pubmed]
  18. Characterization of plant proliferating cell nuclear antigen (PCNA) and flap endonuclease-1 (FEN-1), and their distribution in mitotic and meiotic cell cycles. Kimura, S., Suzuki, T., Yanagawa, Y., Yamamoto, T., Nakagawa, H., Tanaka, I., Hashimoto, J., Sakaguchi, K. Plant J. (2001) [Pubmed]
  19. Localization of mouse Rad51 and Lim15 proteins on meiotic chromosomes at late stages of prophase 1. Ikeya, T., Shinohara, A., Sato, S., Tabata, S., Ogawa, T. Genes Cells (1996) [Pubmed]
  20. Distribution of Atr protein in primary spermatocytes of a mouse chromosomal mutant: a comparison of preparation techniques. Baart, E.B., de Rooij, D.G., Keegan, K.S., de Boer, P. Chromosoma (2000) [Pubmed]
  21. Nonhomologous synapsis of the XY during early pachynema in In(X)1H male mice. Ashley, T. Genetica (1987) [Pubmed]
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