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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Fatty acid incorporation depicts brain activity in a rat model of Parkinson's disease.

Following pulse labeling with [3H]arachidonic acid ([3H]AA), its incorporation pattern in brain reflects regional changes in neurotransmitter signal transduction using phospholipase A2, that is, functional activity. In a rat model of Parkinson's disease, unilateral 6-hydroxydopamine lesion in the substantia nigra, [3H]AA acid incorporation from blood was increased in cerebral cortex, caudate putamen, globus pallidus, entopeduncular nucleus, subthalamic nucleus and substantia nigra pars reticulata ipsilateral to the lesion. This increased [3H]AA incorporation likely reflects disinhibition of basal ganglia and cortical circuits secondary to absent inhibitory nigrostriatal dopaminergic input.[1]


  1. Fatty acid incorporation depicts brain activity in a rat model of Parkinson's disease. Hayakawa, T., Chang, M.C., Bell, J.M., Seeman, R., Rapoport, S.I., Appel, N.M. Brain Res. (1998) [Pubmed]
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