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MeSH Review

Subthalamic Nucleus

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Disease relevance of Subthalamic Nucleus


Psychiatry related information on Subthalamic Nucleus


High impact information on Subthalamic Nucleus


Chemical compound and disease context of Subthalamic Nucleus


Biological context of Subthalamic Nucleus


Anatomical context of Subthalamic Nucleus


Associations of Subthalamic Nucleus with chemical compounds

  • Cholinergic, GABAergic, and glutamate-enriched inputs from the mesopontine tegmentum to the subthalamic nucleus in the rat [27].
  • The reduced severity of LIDs in the absence of subthalamic nucleus stimulation demonstrates that the sensitization phenomenon resulting from long-term intermittent levodopa administration is partially reversible [28].
  • Ablation of the subthalamic nucleus supports the survival of nigral dopaminergic neurons after nigrostriatal lesions induced by the mitochondrial toxin 3-nitropropionic acid [29].
  • Local field potentials (LFPs) were recorded from adjacent subthalamic nucleus macroelectrode (STNME) contacts simultaneously with EEG activity over the supplementary motor (Cz-FCz) and sensorimotor (C3/4-FC3/4) areas and EMG activity from the contralateral wrist extensors during isometric and phasic wrist movements [30].
  • Modifications of local cerebral metabolic rates for glucose and motor behavior in rats with unilateral lesion of the subthalamic nucleus [31].

Gene context of Subthalamic Nucleus


Analytical, diagnostic and therapeutic context of Subthalamic Nucleus


  1. Chronic stimulation of subthalamic nucleus improves levodopa-induced dyskinesias in Parkinson's disease. Krack, P., Limousin, P., Benabid, A.L., Pollak, P. Lancet (1997) [Pubmed]
  2. Dyskinesias and grip control in Parkinson's disease are normalized by chronic stimulation of the subthalamic nucleus. Wenzelburger, R., Zhang, B.R., Poepping, M., Schrader, B., Müller, D., Kopper, F., Fietzek, U., Mehdorn, H.M., Deuschl, G., Krack, P. Ann. Neurol. (2002) [Pubmed]
  3. Chorea and myoclonus in the monkey induced by gamma-aminobutyric acid antagonism in the lentiform complex. The site of drug action and a hypothesis for the neural mechanisms of chorea. Crossman, A.R., Mitchell, I.J., Sambrook, M.A., Jackson, A. Brain (1988) [Pubmed]
  4. Ineffective subthalamic nucleus stimulation in levodopa-resistant postischemic parkinsonism. Krack, P., Dowsey, P.L., Benabid, A.L., Acarin, N., Benazzouz, A., Künig, G., Leenders, K.L., Obeso, J.A., Pollak, P. Neurology (2000) [Pubmed]
  5. Intrasubthalamic nucleus metabotropic glutamate receptor activation: a behavioral, Fos immunohistochemical and [14C]2-deoxyglucose autoradiographic study. Kearney, J.A., Albin, R.L. Neuroscience (2000) [Pubmed]
  6. Reaction time performance following unilateral striatal dopamine depletion and lesions of the subthalamic nucleus in the rat. Phillips, J.M., Brown, V.J. Eur. J. Neurosci. (1999) [Pubmed]
  7. Functional anatomy of movement disorders. Crossman, A.R. J. Anat. (2000) [Pubmed]
  8. Reversal of experimental parkinsonism by lesions of the subthalamic nucleus. Bergman, H., Wichmann, T., DeLong, M.R. Science (1990) [Pubmed]
  9. A direct role of dopamine in the rat subthalamic nucleus and an adjacent intrapeduncular area. Brown, L.L., Markman, M.H., Wolfson, L.I., Dvorkin, B., Warner, C., Katzman, R. Science (1979) [Pubmed]
  10. Metabolic effects of nigrostriatal denervation in basal ganglia. Hirsch, E.C., Périer, C., Orieux, G., François, C., Féger, J., Yelnik, J., Vila, M., Levy, R., Tolosa, E.S., Marin, C., Trinidad Herrero, M., Obeso, J.A., Agid, Y. Trends Neurosci. (2000) [Pubmed]
  11. The subthalamic nucleus exerts opposite control on cocaine and 'natural' rewards. Baunez, C., Dias, C., Cador, M., Amalric, M. Nat. Neurosci. (2005) [Pubmed]
  12. The response of subthalamic nucleus neurons to dopamine receptor stimulation in a rodent model of Parkinson's disease. Kreiss, D.S., Mastropietro, C.W., Rawji, S.S., Walters, J.R. J. Neurosci. (1997) [Pubmed]
  13. In a rat model of parkinsonism, lesions of the subthalamic nucleus reverse increases of reaction time but induce a dramatic premature responding deficit. Baunez, C., Nieoullon, A., Amalric, M. J. Neurosci. (1995) [Pubmed]
  14. Metabolic changes following subthalamotomy for advanced Parkinson's disease. Su, P.C., Ma, Y., Fukuda, M., Mentis, M.J., Tseng, H.M., Yen, R.F., Liu, H.M., Moeller, J.R., Eidelberg, D. Ann. Neurol. (2001) [Pubmed]
  15. Subthalamic nucleus lesion in rats prevents dopaminergic nigral neuron degeneration after striatal 6-OHDA injection: behavioural and immunohistochemical studies. Piallat, B., Benazzouz, A., Benabid, A.L. Eur. J. Neurosci. (1996) [Pubmed]
  16. Effects of transient inactivation of the subthalamic nucleus by local muscimol and APV infusions on performance on the five-choice serial reaction time task in rats. Baunez, C., Robbins, T.W. Psychopharmacology (Berl.) (1999) [Pubmed]
  17. PITX2 is required for normal development of neurons in the mouse subthalamic nucleus and midbrain. Martin, D.M., Skidmore, J.M., Philips, S.T., Vieira, C., Gage, P.J., Condie, B.G., Raphael, Y., Martinez, S., Camper, S.A. Dev. Biol. (2004) [Pubmed]
  18. Presynaptic inhibition of synaptic transmission by adenosine in rat subthalamic nucleus in vitro. Shen, K.Z., Johnson, S.W. Neuroscience (2003) [Pubmed]
  19. Ablation of the subthalamic nucleus protects dopaminergic phenotype but not cell survival in a rat model of Parkinson's disease. Paul, G., Meissner, W., Rein, S., Harnack, D., Winter, C., Hosmann, K., Morgenstern, R., Kupsch, A. Exp. Neurol. (2004) [Pubmed]
  20. Dopamine D1/5 receptor stimulation induces c-fos expression in the subthalamic nucleus: possible involvement of local D5 receptors. Svenningsson, P., Le Moine, C. Eur. J. Neurosci. (2002) [Pubmed]
  21. Effect of a functional impairment of corticostriatal transmission on cortically evoked expression of c-Fos and zif 268 in the rat basal ganglia. Sgambato, V., Maurice, N., Besson, M.J., Thierry, A.M., Deniau, J.M. Neuroscience (1999) [Pubmed]
  22. Modeling facilitation and inhibition of competing motor programs in basal ganglia subthalamic nucleus-pallidal circuits. Rubchinsky, L.L., Kopell, N., Sigvardt, K.A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  23. Differential distribution of AT1 and AT2 angiotensin II receptor subtypes in the rat brain during development. Millan, M.A., Jacobowitz, D.M., Aguilera, G., Catt, K.J. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  24. Subthalamic nucleus lesions: widespread effects on changes in gene expression induced by nigrostriatal dopamine depletion in rats. Delfs, J.M., Ciaramitaro, V.M., Parry, T.J., Chesselet, M.F. J. Neurosci. (1995) [Pubmed]
  25. Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat. Testa, C.M., Standaert, D.G., Young, A.B., Penney, J.B. J. Neurosci. (1994) [Pubmed]
  26. Excitotoxicity and nitric oxide in Parkinson's disease pathogenesis. Beal, M.F. Ann. Neurol. (1998) [Pubmed]
  27. Cholinergic, GABAergic, and glutamate-enriched inputs from the mesopontine tegmentum to the subthalamic nucleus in the rat. Bevan, M.D., Bolam, J.P. J. Neurosci. (1995) [Pubmed]
  28. Levodopa-induced dyskinesias in Parkinson's disease: is sensitization reversible? Bejjani, B.P., Arnulf, I., Demeret, S., Damier, P., Bonnet, A.M., Houeto, J.L., Agid, Y. Ann. Neurol. (2000) [Pubmed]
  29. Ablation of the subthalamic nucleus supports the survival of nigral dopaminergic neurons after nigrostriatal lesions induced by the mitochondrial toxin 3-nitropropionic acid. Nakao, N., Nakai, E., Nakai, K., Itakura, T. Ann. Neurol. (1999) [Pubmed]
  30. Subthalamic nucleus, sensorimotor cortex and muscle interrelationships in Parkinson's disease. Marsden, J.F., Limousin-Dowsey, P., Ashby, P., Pollak, P., Brown, P. Brain (2001) [Pubmed]
  31. Modifications of local cerebral metabolic rates for glucose and motor behavior in rats with unilateral lesion of the subthalamic nucleus. Blandini, F., Conti, G., Martignoni, E., Colangelo, V., Nappi, G., Di Grezia, R., Orzi, F. J. Cereb. Blood Flow Metab. (1999) [Pubmed]
  32. Domain analysis of the calcium-activated potassium channel SK1 from rat brain. Functional expression and toxin sensitivity. D'hoedt, D., Hirzel, K., Pedarzani, P., Stocker, M. J. Biol. Chem. (2004) [Pubmed]
  33. Estrogen receptor beta (ERbeta) messenger ribonucleic acid (mRNA) expression within the human forebrain: distinct distribution pattern to ERalpha mRNA. Osterlund, M.K., Gustafsson, J.A., Keller, E., Hurd, Y.L. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  34. Differential distribution of butyrylcholinesterase and acetylcholinesterase in the human thalamus. Darvesh, S., Hopkins, D.A. J. Comp. Neurol. (2003) [Pubmed]
  35. Parvalbumin and calbindin D-28k in the entopeduncular nucleus, subthalamic nucleus, and substantia nigra of the rat as revealed by double-immunohistochemical methods. Hontanilla, B., Parent, A., Giménez-Amaya, J.M. Synapse (1997) [Pubmed]
  36. Expression and activity of antioxidants in the brain in progressive supranuclear palsy. Cantuti-Castelvetri, I., Keller-McGandy, C.E., Albers, D.S., Beal, M.F., Vonsattel, J.P., Standaert, D.G., Augood, S.J. Brain Res. (2002) [Pubmed]
  37. Deep brain stimulation of the subthalamic nucleus enhances emotional processing in Parkinson disease. Schneider, F., Habel, U., Volkmann, J., Regel, S., Kornischka, J., Sturm, V., Freund, H.J. Arch. Gen. Psychiatry (2003) [Pubmed]
  38. Systemic administration of NMDA and AMPA receptor antagonists reverses the neurochemical changes induced by nigrostriatal denervation in basal ganglia. Vila, M., Marin, C., Ruberg, M., Jimenez, A., Raisman-Vozari, R., Agid, Y., Tolosa, E., Hirsch, E.C. J. Neurochem. (1999) [Pubmed]
  39. Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter. Aihara, Y., Mashima, H., Onda, H., Hisano, S., Kasuya, H., Hori, T., Yamada, S., Tomura, H., Yamada, Y., Inoue, I., Kojima, I., Takeda, J. J. Neurochem. (2000) [Pubmed]
  40. Future and current surgical therapies in Parkinson's disease. Betchen, S.A., Kaplitt, M. Curr. Opin. Neurol. (2003) [Pubmed]
  41. Electrophysiological study of the excitatory parafascicular projection to the subthalamic nucleus and evidence for ipsi- and contralateral controls. Mouroux, M., Hassani, O.K., Féger, J. Neuroscience (1995) [Pubmed]
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