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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor.

Clonal deletion in the thymus by apoptosis is involved in purging the immune system of self-reactive T lymphocytes (negative selection). Cysteine proteases (caspases) belonging to the CPP32 family are activated during this process. We have produced transgenic mice expressing baculovirus p35, a broad-range caspase inhibitor. Thymocytes from p35 transgenic mice were resistant in vitro to several apoptosis-inducing agents; this resistance correlated with the inhibition of CPP32-like activity. Negative selection in vivo of thymocytes triggered by two exogenous antigens, staphylococcal enterotoxin B superantigen and an antigenic peptide in the F5 T-cell receptor transgenic model, was specifically inhibited in p35 transgenic mice. Our results provide direct evidence for caspase involvement in negative selection during thymocyte development.[1]

References

  1. Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor. Izquierdo, M., Grandien, A., Criado, L.M., Robles, S., Leonardo, E., Albar, J.P., de Buitrago, G.G., Martínez-A, C. EMBO J. (1999) [Pubmed]
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