Chemical Compound Review:
Lopac-D-5919 3-[2-[4-[(4-fluorophenyl)- phenyl...
Synonyms:
Tocris-2194, CHEMBL259388, SureCN316891, AG-K-43092, D5919_SIGMA, ...
- Intracellular calcium mobilization and phospholipid degradation in sphingosylphosphorylcholine-stimulated human airway epithelial cells. Orlati, S., Porcelli, A.M., Hrelia, S., Lorenzini, A., Rugolo, M. Biochem. J. (1998)
- Effects of bradykinin, GTP gamma S, R59022 and N-ethylmaleimide on inositol phosphate production in NG108-15 cells. Chiang, C.F., Hauser, G. Biochem. Biophys. Res. Commun. (1989)
- Shape changes and chemokinesis of Walker carcinosarcoma cells: effects of protein kinase inhibitors (HA-1004, polymyxin B, sangivamycin and tamoxifen) and an inhibitor of diacylglycerol kinase (R 59022). Zimmermann, A., Keller, H. Anticancer Res. (1993)
- The diacylglycerol kinase inhibitor, R 59022, suppresses contractility of intestinal smooth muscle. Lippe, I.T., Holzer, P. Eur. J. Pharmacol. (1989)
- Enhanced nuclear diacylglycerol kinase activity in response to a mitogenic stimulation of quiescent Swiss 3T3 cells with insulin-like growth factor I. Martelli, A.M., Tabellini, G., Bortul, R., Manzoli, L., Bareggi, R., Baldini, G., Grill, V., Zweyer, M., Narducci, P., Cocco, L. Cancer Res. (2000)
- Protein kinase C down-regulation, and not transient activation, correlates with melanocyte growth. Brooks, G., Wilson, R.E., Dooley, T.P., Goss, M.W., Hart, I.R. Cancer Res. (1991)
- Differential effects of various protein kinase C activators on protein phosphorylation in human acute myeloblastic leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a. Kiss, Z., Deli, E., Shoji, M., Koeffler, H.P., Pettit, G.R., Vogler, W.R., Kuo, J.F. Cancer Res. (1987)
- Arabidopsis AtDGK7, the smallest member of plant diacylglycerol kinases (DGKs), displays unique biochemical features and saturates at low substrate concentration: the DGK inhibitor R59022 differentially affects AtDGK2 and AtDGK7 activity in vitro and alters plant growth and development. Gómez-Merino, F.C., Arana-Ceballos, F.A., Trejo-Téllez, L.I., Skirycz, A., Brearley, C.A., Dörmann, P., Mueller-Roeber, B. J. Biol. Chem. (2005)
- Subtype-specific translocation of diacylglycerol kinase alpha and gamma and its correlation with protein kinase C. Shirai, Y., Segawa, S., Kuriyama, M., Goto, K., Sakai, N., Saito, N. J. Biol. Chem. (2000)
- Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal. Fukami, K., Takenawa, T. J. Biol. Chem. (1992)
- R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet. de Chaffoy de Courcelles, D.C., Roevens, P., Van Belle, H. J. Biol. Chem. (1985)
- The role of diacylglycerol in the exocytosis of the sperm acrosome. Studies using diacylglycerol lipase and diacylglycerol kinase inhibitors and exogenous diacylglycerols. Roldan, E.R., Harrison, R.A. Biochem. J. (1992)
- Different effects of sphingosine, R59022 and anionic amphiphiles on two diacylglycerol kinase isozymes purified from porcine thymus cytosol. Sakane, F., Yamada, K., Kanoh, H. FEBS Lett. (1989)
- A diacylglycerol kinase inhibitor, R 59 022, potentiates superoxide anion production and 46-kDa protein phosphorylation in guinea pig polymorphonuclear leukocytes. Ohtsuka, T., Hiura, M., Yoshida, K., Okamura, N., Ishibashi, S. J. Biol. Chem. (1990)
- Involvement of protein kinase C and protein tyrosine kinase in lipopolysaccharide-induced TNF-alpha and IL-1 beta production by human monocytes. Shapira, L., Takashiba, S., Champagne, C., Amar, S., Van Dyke, T.E. J. Immunol. (1994)
- Novel diacylglycerol kinase inhibitor selectively suppressed an U46619-induced enhancement of mouse portal vein contraction under high glucose conditions. Nobe, K., Miyatake, M., Nobe, H., Sakai, Y., Takashima, J., Momose, K. Br. J. Pharmacol. (2004)
- Increased protein synthesis response to insulin in fibroblasts treated with the diacylglycerol kinase inhibitor R59022. Hesketh, J.E., McKenzie, N., Campbell, G.P. FEBS Lett. (1988)
- Effects of prolonged EGF treatment on phospholipid turnover and DAG formation in murine keratinocytes. Punnonen, K., Isoherranen, K., Laihia, J., Leino, L. Cell. Signal. (1996)
- Peroxides of vanadate induce activation of phospholipase D in HL-60 cells. Role of tyrosine phosphorylation. Bourgoin, S., Grinstein, S. J. Biol. Chem. (1992)
- A diacylglycerol kinase inhibitor, R59022, potentiates secretion by and aggregation of thrombin-stimulated human platelets. Nunn, D.L., Watson, S.P. Biochem. J. (1987)
- Relationship of phospholipase C- and phospholipase D-mediated phospholipid remodeling pathways to respiratory burst activation in human neutrophils stimulated by Candida albicans hyphae. Meshulam, T., Billah, M.M., Eckel, S., Griendling, K.K., Diamond, R.D. J. Leukoc. Biol. (1995)
- Erythropoietin stimulates G-protein-coupled phospholipase D in haematopoietic target cells. Clejan, S., Mallia, C., Vinson, D., Dotson, R., Beckman, B.S. Biochem. J. (1996)
- Inhibition of high-affinity gamma-aminobutyric acid uptake in primary astrocyte cultures by phorbol esters and phospholipase C. Gomeza, J., Casado, M., Gimenez, C., Aragon, C. Biochem. J. (1991)
- Fibroblast growth factor stimulates protein kinase C in quiescent 3T3 cells without Ca2+ mobilization or inositol phosphate accumulation. Nånberg, E., Morris, C., Higgins, T., Vara, F., Rozengurt, E. J. Cell. Physiol. (1990)
- Purification and characterization of cytosolic diacylglycerol kinases of human platelets. Yada, Y., Ozeki, T., Kanoh, H., Nozawa, Y. J. Biol. Chem. (1990)
- Diacylglycerol inhibits potassium-induced calcium influx and insulin release by a protein kinase-C-independent mechanism in HIT T-15 islet cells. Thomas, T.P., Pek, S.B. Endocrinology (1992)
- Effects of the diacylglycerol kinase inhibitor, R59022, on TSH-stimulated iodide organification in porcine thyroid cells. Matowe, W.C., Ginsberg, J. Pharmacology (1996)