Gene Review:
TRIM28 - tripartite motif containing 28
Homo sapiens
Synonyms:
E3 SUMO-protein ligase TRIM28, KAP-1, KAP1, KRAB-associated protein 1, KRAB-interacting protein 1, ...
- The Epstein-Barr virus replication protein BBLF2/3 provides an origin-tethering function through interaction with the zinc finger DNA binding protein ZBRK1 and the KAP-1 corepressor. Liao, G., Huang, J., Fixman, E.D., Hayward, S.D. J. Virol. (2005)
- Association of the transcriptional corepressor TIF1beta with heterochromatin protein 1 (HP1): an essential role for progression through differentiation. Cammas, F., Herzog, M., Lerouge, T., Chambon, P., Losson, R. Genes Dev. (2004)
- Differential effects of retinoic acid isomers on the expression of nuclear receptor co-regulators in neuroblastoma. Lovat, P.E., Annicchiarico-Petruzzelli, M., Corazzari, M., Dobson, M.G., Malcolm, A.J., Pearson, A.D., Melino, G., Redfern, C.P. FEBS Lett. (1999)
- SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Schultz, D.C., Ayyanathan, K., Negorev, D., Maul, G.G., Rauscher, F.J. Genes Dev. (2002)
- TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937. Rooney, J.W., Calame, K.L. Genes Dev. (2001)
- Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. Nielsen, A.L., Ortiz, J.A., You, J., Oulad-Abdelghani, M., Khechumian, R., Gansmuller, A., Chambon, P., Losson, R. EMBO J. (1999)
- MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. Wang, C., Ivanov, A., Chen, L., Fredericks, W.J., Seto, E., Rauscher, F.J., Chen, J. EMBO J. (2005)
- Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1. Moosmann, P., Georgiev, O., Le Douarin, B., Bourquin, J.P., Schaffner, W. Nucleic Acids Res. (1996)
- Oligomerization of transcriptional intermediary factor 1 regulators and interaction with ZNF74 nuclear matrix protein revealed by bioluminescence resonance energy transfer in living cells. Germain-Desprez, D., Bazinet, M., Bouvier, M., Aubry, M. J. Biol. Chem. (2003)
- Polymorphisms in the human high sulfur hair keratin-associated protein 1, KAP1, gene family. Shimomura, Y., Aoki, N., Schweizer, J., Langbein, L., Rogers, M.A., Winter, H., Ito, M. J. Biol. Chem. (2002)
- KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction. Okamoto, K., Kitabayashi, I., Taya, Y. Biochem. Biophys. Res. Commun. (2006)
- Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction. Cammas, F., Oulad-Abdelghani, M., Vonesch, J.L., Huss-Garcia, Y., Chambon, P., Losson, R. J. Cell. Sci. (2002)
- Purification and biochemical characterization of proteins which bind to the H-box cis-element implicated in transcriptional activation of plant defense genes. Yu, L.M., Lamb, C.J., Dixon, R.A. Plant J. (1993)
- The KRAB-associated co-repressor KAP-1 is a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase. Delfino, F.J., Shaffer, J.M., Smithgall, T.E. Biochem. J. (2006)
- Transcriptional repression mediated by the KRAB domain of the human C2H2 zinc finger protein Kox1/ZNF10 does not require histone deacetylation. Lorenz, P., Koczan, D., Thiesen, H.J. Biol. Chem. (2001)
- Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Krüppel-associated box protein. Gebelein, B., Urrutia, R. Mol. Cell. Biol. (2001)
- A novel transrepression pathway of c-Myc. Recruitment of a transcriptional corepressor complex to c-Myc by MM-1, a c-Myc-binding protein. Satou, A., Taira, T., Iguchi-Ariga, S.M., Ariga, H. J. Biol. Chem. (2001)
- Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway. Ziv, Y., Bielopolski, D., Galanty, Y., Lukas, C., Taya, Y., Schultz, D.C., Lukas, J., Bekker-Jensen, S., Bartek, J., Shiloh, Y. Nat. Cell Biol. (2006)
- Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression. Li, X., Lee, Y.K., Jeng, J.C., Yen, Y., Schultz, D.C., Shih, H.M., Ann, D.K. J. Biol. Chem. (2007)
- A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1. Underhill, C., Qutob, M.S., Yee, S.P., Torchia, J. J. Biol. Chem. (2000)
- The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain. Lechner, M.S., Schultz, D.C., Negorev, D., Maul, G.G., Rauscher, F.J. Biochem. Biophys. Res. Commun. (2005)
- TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77. Rambaud, J., Desroches, J., Balsalobre, A., Drouin, J. J. Biol. Chem. (2009)
- Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential. Lechner, M.S., Begg, G.E., Speicher, D.W., Rauscher, F.J. Mol. Cell. Biol. (2000)
- Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells. Lee, Y.K., Thomas, S.N., Yang, A.J., Ann, D.K. J. Biol. Chem. (2007)
- Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain. Peng, H., Begg, G.E., Harper, S.L., Friedman, J.R., Speicher, D.W., Rauscher, F.J. J. Biol. Chem. (2000)
- Binding of two nuclear complexes to a novel regulatory element within the human S100A9 promoter drives the S100A9 gene expression. Kerkhoff, C., Hofmann, H.A., Vormoor, J., Melkonyan, H., Roth, J., Sorg, C., Klempt, M. J. Biol. Chem. (2002)