The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

C12orf57  -  chromosome 12 open reading frame 57

Homo sapiens

Synonyms: C10, GRCC10, Protein C10
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of C12orf57

  • A 1-year-old infant with classic Werdnig-Hoffmann disease was found to excrete abnormally large amounts of dicarboxylic acids in both fed and fasting states, with especially notable increases in the longer-chain (C10 and C12) 3-hydroxydicarboxylic acids [1].
  • For C10, the N-S two-site jump model or Gaussian distribution of the torsion angle model could explain the observed J values, and 68% S-type conformation or C1'-exo conformation with 27 degrees distribution was obtained, respectively [2].
  • T47D human breast cancer cells were grown in 1 microM benzo[a]pyrene (BaP) for 3.5 months, and 2 BaP-resistant (BaPr) variant cell lines (CS and C10) were isolated [3].
  • Various phosphonium salts possessing single or double alkyl chains of various lengths (C10 to C18) were prepared as cationic biocides, and their antimicrobial activities against 11 typical strains of microorganisms including methicillin-resistant Staphylococcus aureus (MRSA) were evaluated [4].
  • We hypothesize that the lung becomes predisposed to nosocomial infections for extended periods of time after severe sepsis via mechanisms that include alterations in inflammatory cytokines and an increase in immunomodulatory chemokines, such as monocyte chemoattractant protein-1 and C10 [5].
 

Psychiatry related information on C12orf57

  • Suberylglycine (HOOC(CH2)6CONHCH2COOH) was found in the urine from a patient with C6-C10-omega-dicarboxylic aciduria and unexplained episodes of lethargy and unconsciousness [6].
 

High impact information on C12orf57

  • We find that trypanosome fatty acid synthesis is modular, with ELO1 converting C4 to C10, ELO2 extending C10 to C14, and ELO3 elongating C14 to C18 [7].
  • These effects increased according to the elongation of the carbon chain of 1-alkanols from ethanol (C2) to 1-decanol (C10), but suddenly almost disappeared at 1-tetradecanol (C14) [8].
  • Catalytic ethylene oligomerization represents a topic of considerable current academic and industrial interest, in particular for the production of linear alpha-olefins in the C4-C10 range, whose demand is growing fast [9].
  • The precursor of all monoterpenes is the C10 acyclic intermediate geranyl diphosphate (GPP), which is formed from the C5 compounds isopentenyl diphosphate and dimethylallyl diphosphate by GPP synthase (GPPS) [10].
  • This phenomenon was demonstrated by cloning and characterizing a cytochrome P450 gene (Pinene Hydroxylase) that encodes the enzyme catalyzing the C10 hydroxylation of alpha-pinene to myrtenol [11].
 

Chemical compound and disease context of C12orf57

  • DNA polymerase alpha and HIV-1 reverse transcriptase were blocked 3' to the adduct when the configuration at C10 of the hdyrocarbon was S, and some introduction of thymine opposite the adenine adduct was seen with the R configuration [12].
  • Heterologous expression of P. aeruginosa pagL in Salmonella enterica serovar Typhimurium and Escherichia coli resulted in removal of the 3-OH C14 fatty acid from lipid A, indicating that P. aeruginosa PagL recognizes either 3-OH C10 or 3-OH C14 [13].
  • Cyclooctenones deoxygenated at the C2 or C10 position in the taxane framework are prepared by dehydration of the above aldols [14].
  • Three series of monoacyl-2-O-beta-D-galactosylglycerols bearing an acyl chain of varying length, from C4 to C10, were studied due to their antitumor promoting effects on the activation of the Epstein-Barr virus early antigen (EBV-EA), such activation being induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) [15].
  • The methyl substitution at positions C9 or C10 increased the T antigen expression of adenovirus infected cells [16].
 

Biological context of C12orf57

  • Protein kinase C is thought to be physiologically activated by diacylglycerol derived from receptor-mediated phosphatidylinositol hydrolysis. sn-1,2-diacylglycerols with short saturated acyl side chains (C4-C10) were synthesized and found to be potent activators of protein kinase C partially purified from HL-60 cells [17].
  • For the alpha 2AAR (human alpha 2 C10) palmitoylation occurs at Cys-442, but it is not known what function such fatty acid acylation subserves [18].
  • We have cloned a human alpha 2AR by using the polymerase chain reaction with oligonucleotide primers homologous to conserved regions of the previously cloned alpha 2ARs, the genes for which are located on human chromosomes 4 (C4) and 10 (C10) [19].
  • HCC-2 shares significant sequence homology with CKbeta8 and the murine chemokines C10, CCF18/MRP-2, and macrophage inflammatory protein 1gamma, which all contain six instead of four conserved cysteines [20].
  • The phenotypes of the majority of the Gpt- derivatives of C10 could be attributed to alterations in gene expression caused by methylation [21].
 

Anatomical context of C12orf57

  • Spontaneous Gpt- derivatives of the other cell line (C10) produced a completely different spectrum of alterations [21].
  • Collectively, these data suggest that the human T-cell line C10/MJ-2 constitutively produces a diffusable product distinct from IFN-gamma which activates human monocytes to lyse tumor cells [22].
  • Short/medium-chain (C4-C10) triacylglycerols were degraded at a normal rate in NLSD fibroblasts, whereas long-chain (C12 and longer) triacylglycerols remained undegraded [23].
  • In general, short chain acyl groups (C2 and C3) are more reactive than longer chains (C4 to C10), but longer chains may be more effective with intact red cells because of their enhanced ability to permeate the erythrocyte membrane [24].
  • A nucleotide sequence similar or identical with C10 AUACC is found in most other eukaryotic 5 S RNAs, including the 5 S RNA from human KB cells [25].
 

Associations of C12orf57 with chemical compounds

  • The present adduct derives from trans opening at C10 of the (-)-(7S,8R)-diol (9R,10S)-epoxide enantiomer by the exocyclic N(2)-amino group of deoxyguanosine [26].
  • Criteria for the unequivocal diagnosis of MCAD deficiency by acylcarnitine analysis are an elevated C8-acylcarnitine concentration (> 0.3 microM), a ratio of C8/C10 acylcarnitines of > 5, and lack of elevated species of chain length > C10 [27].
  • Furthermore, this MAF activity was not due to contamination with endotoxins since the Limulus amebocyte lysate assay was negative (less than 0.125 ng/ml) and preincubation of the C10/MJ-2 supernatant fluid with polymyxin B did not diminish its activating potential [22].
  • The pentafluorobenzyl esters prepared from an acid hydrolysate analyzed by negative ion chemical ionization gas chromatography mass spectrometry confirmed that C6, C8, and C10 fatty acids were present [28].
  • Short/medium-chain fatty acids (C4-C10) were incorporated into polar lipids (60-80%) and triacylglycerols (20-40%) at a lower rate (5-10 times lower) than long-chain fatty acids [23].
 

Analytical, diagnostic and therapeutic context of C12orf57

  • Anesthetic potencies of these alkanols, estimated by the activity of brine shrimps, were linearly related to hydrogen bond-breaking activities below C10 and agreed with the FTIR data in the cutoff at C10 [8].
  • A method utilizing thin-layer chromatography, high performance liquid chromatography, and mass spectrometry was developed for the quantification of C9, C10, C11, and C12 dicarboxylic acids in serum, urine, and feces of human volunteers and rats after oral administration of the acids [29].
  • Stereoisomeric anti-BPDE-modified oligonucleotide adducts in the sequence 5'-d(CC-AT-CG*CTACC)-3' where G* = anti-BPDE-N2-dG with (+)-trans, (-)-trans, (+)-cis and (-)-cis adduct stereochemistry at the C10 position of anti-BPDE were tested by competitive ELISA [30].
  • Adducts in which either (+)-anti-BPDE or (-)-anti-BPDE are covalently bound via their C10 positions by trans addition to the exocyclic amino group of the single G residues were isolated and purified by HPLC methods [31].
  • Arachidonate diminished the affinity for the C10 azole sufficiently that a Kd could be determined by spectrophotometric titration (11 microM) [32].

References

  1. Dicarboxylic aciduria in an infant with spinal muscular atrophy. Kelley, R.I., Sladky, J.T. Ann. Neurol. (1986) [Pubmed]
  2. Sugar conformation of a stereospecific 2'-R or 2'-S deuterium-labeled DNA decamer studied with proton-proton J coupling constants. Kojima, C., Kawashima, E., Sekine, T., Ishido, Y., Ono, A., Kainosho, M., Kyogoku, Y. J. Biomol. NMR (2001) [Pubmed]
  3. Isolation and characterization of variant benzo[a]pyrene-resistant T47D human breast-cancer cells. Moore, M., Ruh, M., Steinberg, M., Safe, S. Int. J. Cancer (1996) [Pubmed]
  4. Synthesis and antimicrobial activity of dimethyl- and trimethyl-substituted phosphonium salts with alkyl chains of various lengths. Kanazawa, A., Ikeda, T., Endo, T. Antimicrob. Agents Chemother. (1994) [Pubmed]
  5. The chronic consequences of severe sepsis. Benjamim, C.F., Hogaboam, C.M., Kunkel, S.L. J. Leukoc. Biol. (2004) [Pubmed]
  6. Suberylglycine excretion in the urine from a patient with dicarboxylic aciduria. Gregersen, N., Lauritzen, R., Rasmussen, K. Clin. Chim. Acta (1976) [Pubmed]
  7. Fatty acid synthesis by elongases in trypanosomes. Lee, S.H., Stephens, J.L., Paul, K.S., Englund, P.T. Cell (2006) [Pubmed]
  8. Anesthesia cutoff phenomenon: interfacial hydrogen bonding. Chiou, J.S., Ma, S.M., Kamaya, H., Ueda, I. Science (1990) [Pubmed]
  9. Catalytic ethylene dimerization and oligomerization: recent developments with nickel complexes containing P,N-chelating ligands. Speiser, F., Braunstein, P., Saussine, L. Acc. Chem. Res. (2005) [Pubmed]
  10. Formation of monoterpenes in Antirrhinum majus and Clarkia breweri flowers involves heterodimeric geranyl diphosphate synthases. Tholl, D., Kish, C.M., Orlova, I., Sherman, D., Gershenzon, J., Pichersky, E., Dudareva, N. Plant Cell (2004) [Pubmed]
  11. Gain and loss of fruit flavor compounds produced by wild and cultivated strawberry species. Aharoni, A., Giri, A.P., Verstappen, F.W., Bertea, C.M., Sevenier, R., Sun, Z., Jongsma, M.A., Schwab, W., Bouwmeester, H.J. Plant Cell (2004) [Pubmed]
  12. Primer extension by various polymerases using oligonucleotide templates containing stereoisomeric benzo[a]pyrene-deoxyadenosine adducts. Christner, D.F., Lakshman, M.K., Sayer, J.M., Jerina, D.M., Dipple, A. Biochemistry (1994) [Pubmed]
  13. The Pseudomonas aeruginosa lipid A deacylase: selection for expression and loss within the cystic fibrosis airway. Ernst, R.K., Adams, K.N., Moskowitz, S.M., Kraig, G.M., Kawasaki, K., Stead, C.M., Trent, M.S., Miller, S.I. J. Bacteriol. (2006) [Pubmed]
  14. Preparation of useful synthetic intermediates of Taxol analogs, cyclooctenone derivatives. Yamada, K., Tozawa, T., Saitoh, K., Mukaiyama, T. Chem. Pharm. Bull. (1997) [Pubmed]
  15. Inhibitory effects of monoacylated 2-O-beta-galactosylglycerols on Epstein-Barr virus activation: the significant role of the hexanoyl chain. Colombo, D., Compostella, F., Ronchetti, F., Scala, A., Toma, L., Mukainaka, T., Nagatsu, A., Konoshima, T., Tokuda, H., Nishino, H. Cancer Lett. (1999) [Pubmed]
  16. Relationship between tumor (T) antigen expression and substituent effects on benzo [a] phenothiazines. Pusztai, R., Motohashi, N., Párkányi, C., Aaron, J.J., Rao, B.K., Molnár, J. Anticancer Res. (1996) [Pubmed]
  17. Diacylglycerols mimic phorbol diester induction of leukemic cell differentiation. Ebeling, J.G., Vandenbark, G.R., Kuhn, L.J., Ganong, B.R., Bell, R.M., Niedel, J.E. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  18. The palmitoylated cysteine of the cytoplasmic tail of alpha 2A-adrenergic receptors confers subtype-specific agonist-promoted downregulation. Eason, M.G., Jacinto, M.T., Theiss, C.T., Liggett, S.B. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  19. Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2. Lomasney, J.W., Lorenz, W., Allen, L.F., King, K., Regan, J.W., Yang-Feng, T.L., Caron, M.G., Lefkowitz, R.J. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  20. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. Pardigol, A., Forssmann, U., Zucht, H.D., Loetscher, P., Schulz-Knappe, P., Baggiolini, M., Forssmann, W.G., Mägert, H.J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  21. Inactivation of a transfected gene in human fibroblasts can occur by deletion, amplification, phenotypic switching, or methylation. Gebara, M.M., Drevon, C., Harcourt, S.A., Steingrimsdottir, H., James, M.R., Burke, J.F., Arlett, C.F., Lehmann, A.R. Mol. Cell. Biol. (1987) [Pubmed]
  22. Constitutive production and release of a lymphokine with macrophage-activating factor activity distinct from gamma-interferon by a human T-cell leukemia virus-positive cell line. Kleinerman, E.S., Zicht, R., Sarin, P.S., Gallo, R.C., Fidler, I.J. Cancer Res. (1984) [Pubmed]
  23. The turnover of cytoplasmic triacylglycerols in human fibroblasts involves two separate acyl chain length-dependent degradation pathways. Hilaire, N., Salvayre, R., Thiers, J.C., Bonnafé, M.J., Nègre-Salvayre, A. J. Biol. Chem. (1995) [Pubmed]
  24. Modification of hemoglobin with analogs of aspirin. Zaugg, R.H., Walder, J.A., Walder, R.Y., Steele, J.M., Klotz, I.M. J. Biol. Chem. (1980) [Pubmed]
  25. The nucleotide sequence of spinach cytoplasmic 5 S ribosomal RNA. Delihas, N., Andersen, J., Sprouse, H.M., Kashdan, M., Dudock, B. J. Biol. Chem. (1981) [Pubmed]
  26. Crystal and molecular structure of a benzo[a]pyrene 7,8-diol 9,10-epoxide N2-deoxyguanosine adduct: absolute configuration and conformation. Karle, I.L., Yagi, H., Sayer, J.M., Jerina, D.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  27. Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency: diagnosis by acylcarnitine analysis in blood. Van Hove, J.L., Zhang, W., Kahler, S.G., Roe, C.R., Chen, Y.T., Terada, N., Chace, D.H., Iafolla, A.K., Ding, J.H., Millington, D.S. Am. J. Hum. Genet. (1993) [Pubmed]
  28. The N terminus of human myelin basic protein consists of C2, C4, C6, and C8 alkyl carboxylic acids. Moscarello, M.A., Pang, H., Pace-Asciak, C.R., Wood, D.D. J. Biol. Chem. (1992) [Pubmed]
  29. Metabolism of straight saturated medium chain length (C9 to C12) dicarboxylic acids. Passi, S., Nazzaro-Porro, M., Picardo, M., Mingrone, G., Fasella, P. J. Lipid Res. (1983) [Pubmed]
  30. Determination of stereospecificity of benzo[a]pyrene diolepoxide-DNA antisera with site-specifically modified oligonucleotides. Hsu, T.M., Liu, T.M., Amin, S., Geacintov, N.E., Santella, R.M. Carcinogenesis (1995) [Pubmed]
  31. Opposite stereoselective resistance to digestion by phosphodiesterases I and II of benzo[a]pyrene diol epoxide-modified oligonucleotide adducts. Mao, B., Li, B., Amin, S., Cosman, M., Geacintov, N.E. Biochemistry (1993) [Pubmed]
  32. Imidazolyl carboxylic acids as mechanistic probes of flavocytochrome P-450 BM3. Noble, M.A., Quaroni, L., Chumanov, G.D., Turner, K.L., Chapman, S.K., Hanzlik, R.P., Munro, A.W. Biochemistry (1998) [Pubmed]
 
WikiGenes - Universities