Gene Review:
Asic1 - acid-sensing (proton-gated) ion channel 1
Mus musculus
Synonyms:
AI843610, ASIC, ASIC1, ASIC1 beta, ASIC1a, ...
- Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Xiong, Z.G., Zhu, X.M., Chu, X.P., Minami, M., Hey, J., Wei, W.L., MacDonald, J.F., Wemmie, J.A., Price, M.P., Welsh, M.J., Simon, R.P. Cell (2004)
- Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1. Sluka, K.A., Price, M.P., Breese, N.M., Stucky, C.L., Wemmie, J.A., Welsh, M.J. Pain (2003)
- ASIC3 and ASIC1 mediate FMRFamide-related peptide enhancement of H+-gated currents in cultured dorsal root ganglion neurons. Xie, J., Price, M.P., Wemmie, J.A., Askwith, C.C., Welsh, M.J. J. Neurophysiol. (2003)
- Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning. Wemmie, J.A., Askwith, C.C., Lamani, E., Cassell, M.D., Freeman, J.H., Welsh, M.J. J. Neurosci. (2003)
- Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia. Pignataro, G., Simon, R.P., Xiong, Z.G. Brain (2007)
- Seizure termination by acidosis depends on ASIC1a. Ziemann, A.E., Schnizler, M.K., Albert, G.W., Severson, M.A., Howard, M.A., Welsh, M.J., Wemmie, J.A. Nat. Neurosci. (2008)
- Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. Wemmie, J.A., Coryell, M.W., Askwith, C.C., Lamani, E., Leonard, A.S., Sigmund, C.D., Welsh, M.J. Proc. Natl. Acad. Sci. U.S.A. (2004)
- The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function. Page, A.J., Brierley, S.M., Martin, C.M., Martinez-Salgado, C., Wemmie, J.A., Brennan, T.J., Symonds, E., Omari, T., Lewin, G.R., Welsh, M.J., Blackshaw, L.A. Gastroenterology (2004)
- Acid-sensitive ionic channels in midbrain dopamine neurons are sensitive to ammonium, which may contribute to hyperammonemia damage. Pidoplichko, V.I., Dani, J.A. Proc. Natl. Acad. Sci. U.S.A. (2006)
- The role of the capsaicin receptor TRPV1 and acid-sensing ion channels (ASICS) in proton sensitivity of subpopulations of primary nociceptive neurons in rats and mice. Leffler, A., Mönter, B., Koltzenburg, M. Neuroscience (2006)
- Annexin II light chain p11 promotes functional expression of acid-sensing ion channel ASIC1a. Donier, E., Rugiero, F., Okuse, K., Wood, J.N. J. Biol. Chem. (2005)
- Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b. Bässler, E.L., Ngo-Anh, T.J., Geisler, H.S., Ruppersberg, J.P., Gründer, S. J. Biol. Chem. (2001)
- Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord. Wu, L.J., Duan, B., Mei, Y.D., Gao, J., Chen, J.G., Zhuo, M., Xu, L., Wu, M., Xu, T.L. J. Biol. Chem. (2004)
- Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function. Page, A.J., Brierley, S.M., Martin, C.M., Price, M.P., Symonds, E., Butler, R., Wemmie, J.A., Blackshaw, L.A. Gut (2005)
- Localization and comparative analysis of acid-sensing ion channel (ASIC1, 2, and 3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia. Hughes, P.A., Brierley, S.M., Young, R.L., Blackshaw, L.A. J. Comp. Neurol. (2007)
- Trypsin cleaves acid-sensing ion channel 1a in a domain that is critical for channel gating. Vukicevic, M., Weder, G., Boillat, A., Boesch, A., Kellenberger, S. J. Biol. Chem. (2006)
- ASIC1a-specific modulation of acid-sensing ion channels in mouse cortical neurons by redox reagents. Chu, X.P., Close, N., Saugstad, J.A., Xiong, Z.G. J. Neurosci. (2006)
- Modulation of Acid-sensing Ion Channel Currents, Acid-induced Increase of Intracellular Ca2+, and Acidosis-mediated Neuronal Injury by Intracellular pH. Wang, W.Z., Chu, X.P., Li, M.H., Seeds, J., Simon, R.P., Xiong, Z.G. J. Biol. Chem. (2006)
- Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons. Askwith, C.C., Wemmie, J.A., Price, M.P., Rokhlina, T., Welsh, M.J. J. Biol. Chem. (2004)