The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Cspg4  -  chondroitin sulfate proteoglycan 4

Mus musculus

Synonyms: 4732461B14Rik, AN2, An2, Chondroitin sulfate proteoglycan 4, Chondroitin sulfate proteoglycan NG2, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Cspg4

  • Many highly migratory neural tumors including melanomas express AN2/NG2 [1].
  • To investigate the functional role of NG2 in neovascularization, we have compared pathological retinal and corneal angiogenesis in wild type and NG2 null mice [2].
  • During ischemic retinal neovascularization, ectopic vessels protruding into the vitreous occur twice as frequently in wild type retinas as in NG2 null retinas [2].
  • Pathological angiogenesis is reduced by targeting pericytes via the NG2 proteoglycan [2].
  • Upon injection into tumor-bearing mice, NG2-binding phages specifically homed to tumor vasculature in wild-type mice but did not localize to the tumor vasculature in NG2 knockout mice [3].
 

Psychiatry related information on Cspg4

  • The substitution of AsnH52 influenced the Id recognition but Ag binding was not affected suggesting that Ab2 HIM/3/41 did not mimic the NG2 Ag [4].
 

High impact information on Cspg4

  • Here, we show that >90% of embryonic and adult NG2 cells express Olig2, a basic helix-loop-helix transcription factor required for oligodendrocyte lineage specification [5].
  • Development of NG2 neural progenitor cells requires Olig gene function [5].
  • In the adult central nervous system, two distinct populations of glial cells expressing the chondroitin sulfate proteoglycan NG2 have been described: bipolar progenitor cells and more differentiated "synantocytes." These cells have diverse neurological functions, including critical roles in synaptic transmission, repair, and regeneration [5].
  • Analysis of mice lacking Olig function demonstrates a failure of NG2 cell development at embryonic and perinatal stages that can be rescued by addition of a transgene containing the human OLIG2 locus [5].
  • There was increased angiogenesis in mice lacking beta3-integrins, but no difference in structure of the vessels was observed by histology or by staining for NG2 and smooth muscle actin in pericytes [6].
 

Chemical compound and disease context of Cspg4

 

Biological context of Cspg4

  • In addition, PDGFR-beta inhibition in vivo was accompanied by abnormal microvascular morphogenesis reminiscent of that observed in PDGFR-beta(-/-) mice with significantly reduced immunostaining of the pericyte marker NG2 [8].
  • Failure to observe autophosphorylation of the PDGF (alpha)-receptor in PDGF-AA-treated null cells indicates that the absence of NG2 causes a defect in signal transduction at the level of (alpha)-receptor activation [9].
  • A striking observation is that a subpopulation of cortical, but not white matter NG2(+) cells, elicit depolarization-induced spikes that are akin to immature action potentials [10].
  • We have used immunohistochemistry to study the distribution of the NG2 proteoglycan during bone development in the mouse [11].
  • AN2, the mouse homologue of NG2, is a surface antigen on glial precursor cells implicated in control of cell migration [1].
 

Anatomical context of Cspg4

 

Associations of Cspg4 with chemical compounds

 

Physical interactions of Cspg4

  • NG2 exhibits a PDZ binding motif at the extreme COOH terminus which binds to the seventh PDZ domain of GRIP1 [12].
 

Other interactions of Cspg4

 

Analytical, diagnostic and therapeutic context of Cspg4

References

  1. AN2, the mouse homologue of NG2, is a surface antigen on glial precursor cells implicated in control of cell migration. Stegmüller, J., Schneider, S., Hellwig, A., Garwood, J., Trotter, J. J. Neurocytol. (2002) [Pubmed]
  2. Pathological angiogenesis is reduced by targeting pericytes via the NG2 proteoglycan. Ozerdem, U., Stallcup, W.B. Angiogenesis (2004) [Pubmed]
  3. NG2 proteoglycan-binding peptides target tumor neovasculature. Burg, M.A., Pasqualini, R., Arap, W., Ruoslahti, E., Stallcup, W.B. Cancer Res. (1999) [Pubmed]
  4. Primary structure of the variable regions encoding antibody to NG2, a tumour-specific antigen on the rat chondrosarcoma HSN. Correlation of idiotypic specificities with amino acid sequences. Léger, O., Jackson, E., Dean, C. Mol. Immunol. (1995) [Pubmed]
  5. Development of NG2 neural progenitor cells requires Olig gene function. Ligon, K.L., Kesari, S., Kitada, M., Sun, T., Arnett, H.A., Alberta, J.A., Anderson, D.J., Stiles, C.D., Rowitch, D.H. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  6. Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins. Taverna, D., Moher, H., Crowley, D., Borsig, L., Varki, A., Hynes, R.O. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  7. The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines. Rhodes, K.E., Raivich, G., Fawcett, J.W. Neuroscience (2006) [Pubmed]
  8. Platelet-Derived Growth Factor-{beta} Receptor Activation Is Essential for Fibroblast and Pericyte Recruitment during Cutaneous Wound Healing. Rajkumar, V.S., Shiwen, X., Bostrom, M., Leoni, P., Muddle, J., Ivarsson, M., Gerdin, B., Denton, C.P., Bou-Gharios, G., Black, C.M., Abraham, D.J. Am. J. Pathol. (2006) [Pubmed]
  9. PDGF (alpha)-receptor is unresponsive to PDGF-AA in aortic smooth muscle cells from the NG2 knockout mouse. Grako, K.A., Ochiya, T., Barritt, D., Nishiyama, A., Stallcup, W.B. J. Cell. Sci. (1999) [Pubmed]
  10. NG2-positive cells in the mouse white and grey matter display distinct physiological properties. Chittajallu, R., Aguirre, A., Gallo, V. J. Physiol. (Lond.) (2004) [Pubmed]
  11. Expression of NG2 proteoglycan during endochondral and intramembranous ossification. Fukushi, J., Inatani, M., Yamaguchi, Y., Stallcup, W.B. Dev. Dyn. (2003) [Pubmed]
  12. The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling. Stegmüller, J., Werner, H., Nave, K.A., Trotter, J. J. Biol. Chem. (2003) [Pubmed]
  13. Leptin affects oligodendroglial development in the mouse embryonic cerebral cortex. Udagawa, J., Nimura, M., Otani, H. Neuro Endocrinol. Lett. (2006) [Pubmed]
  14. Bone marrow-derived progenitor cells contribute to experimental choroidal neovascularization. Espinosa-Heidmann, D.G., Caicedo, A., Hernandez, E.P., Csaky, K.G., Cousins, S.W. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  15. Segregated expression of AMPA-type glutamate receptors and glutamate transporters defines distinct astrocyte populations in the mouse hippocampus. Matthias, K., Kirchhoff, F., Seifert, G., Hüttmann, K., Matyash, M., Kettenmann, H., Steinhäuser, C. J. Neurosci. (2003) [Pubmed]
  16. NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. Fukushi, J., Makagiansar, I.T., Stallcup, W.B. Mol. Biol. Cell (2004) [Pubmed]
  17. Number of oligodendrocyte progenitors recruited to the lesioned spinal cord is modulated by the levels of the cell cycle regulatory protein p27Kip-1. Crockett, D.P., Burshteyn, M., Garcia, C., Muggironi, M., Casaccia-Bonnefil, P. Glia (2005) [Pubmed]
  18. The response of embryonal carcinoma cells to retinoic acid depends on colony size. Koopman, P., Cotton, R.G. Differentiation (1986) [Pubmed]
  19. Nestin-expressing cells divide and adopt a complex electrophysiologic phenotype after transient brain ischemia. Kronenberg, G., Wang, L.P., Synowitz, M., Gertz, K., Katchanov, J., Glass, R., Harms, C., Kempermann, G., Kettenmann, H., Endres, M. J. Cereb. Blood Flow Metab. (2005) [Pubmed]
  20. Efficient differentiation and integration of lineage-restricted neural precursors in the traumatically injured adult cat spinal cord. Alexanian, A.R., Crowe, M.J., Kurpad, S.N. J. Neurosci. Methods (2006) [Pubmed]
  21. AN2/NG2 protein-expressing glial progenitor cells in the murine CNS: isolation, differentiation, and association with radial glia. Diers-Fenger, M., Kirchhoff, F., Kettenmann, H., Levine, J.M., Trotter, J. Glia (2001) [Pubmed]
  22. NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis. Ozerdem, U., Grako, K.A., Dahlin-Huppe, K., Monosov, E., Stallcup, W.B. Dev. Dyn. (2001) [Pubmed]
  23. Reactivation by a trans-acting factor of human major histocompatibility complex Ia gene expression in interspecies hybrids between an Ia-negative human B-cell variant and an Ia-positive mouse B-cell lymphoma. Accolla, R.S., Carra, G., Guardiola, J. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  24. Apoptosis and proliferation of oligodendrocyte progenitor cells in the irradiated rodent spinal cord. Atkinson, S.L., Li, Y.Q., Wong, C.S. Int. J. Radiat. Oncol. Biol. Phys. (2005) [Pubmed]
 
WikiGenes - Universities