Gene Review:
RCAN1 - regulator of calcineurin 1
Homo sapiens
Synonyms:
ADAPT78, Adapt78, CSP1, Calcipressin-1, DSC1, ...
- Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells. Hesser, B.A., Liang, X.H., Camenisch, G., Yang, S., Lewin, D.A., Scheller, R., Ferrara, N., Gerber, H.P. Blood (2004)
- Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis. Minami, T., Horiuchi, K., Miura, M., Abid, M.R., Takabe, W., Noguchi, N., Kohro, T., Ge, X., Aburatani, H., Hamakubo, T., Kodama, T., Aird, W.C. J. Biol. Chem. (2004)
- Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q. Strippoli, P., D'Addabbo, P., Lenzi, L., Giannone, S., Canaider, S., Casadei, R., Vitale, L., Carinci, P., Zannotti, M. Mamm. Genome (2002)
- Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles. Yang, J., Rothermel, B., Vega, R.B., Frey, N., McKinsey, T.A., Olson, E.N., Bassel-Duby, R., Williams, R.S. Circ. Res. (2000)
- Down Syndrome Candidate Region 1 Increases the Stability of the I{kappa}B{alpha} Protein: IMPLICATIONS FOR ITS ANTI-INFLAMMATORY EFFECTS. Kim, Y.S., Cho, K.O., Lee, H.J., Kim, S.Y., Sato, Y., Cho, Y.J. J. Biol. Chem. (2006)
- A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart. Fuentes, J.J., Pritchard, M.A., Planas, A.M., Bosch, A., Ferrer, I., Estivill, X. Hum. Mol. Genet. (1995)
- Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease. Ermak, G., Morgan, T.E., Davies, K.J. J. Biol. Chem. (2001)
- GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs. Hilioti, Z., Gallagher, D.A., Low-Nam, S.T., Ramaswamy, P., Gajer, P., Kingsbury, T.J., Birchwood, C.J., Levchenko, A., Cunningham, K.W. Genes Dev. (2004)
- A conserved family of calcineurin regulators. Kingsbury, T.J., Cunningham, K.W. Genes Dev. (2000)
- Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo. Chan, B., Greenan, G., McKeon, F., Ellenberger, T. Proc. Natl. Acad. Sci. U.S.A. (2005)
- The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: implications for mental retardation. Chang, K.T., Shi, Y.J., Min, K.T. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo. Rothermel, B.A., McKinsey, T.A., Vega, R.B., Nicol, R.L., Mammen, P., Yang, J., Antos, C.L., Shelton, J.M., Bassel-Duby, R., Olson, E.N., Williams, R.S. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Application of Alu-splice PCR on chromosome 21: DSCR1 and Intersectin. Fuentes, J.J., Dierssen, M., Pucharcós, C., Fillat, C., Casas, C., Estivill, X., Pritchard, M. J. Neural Transm. Suppl. (1999)
- Characterization of two labor-induced genes, DSCR1 and TCTE1L, in the pregnant ovine myometrium. Wu, W.X., Ma, X.H., Zhang, Q., Chakrabarty, K., Nathanielsz, P.W. J. Endocrinol. (2003)
- The murine DSCR1-like (Down syndrome candidate region 1) gene family: conserved synteny with the human orthologous genes. Strippoli, P., Petrini, M., Lenzi, L., Carinci, P., Zannotti, M. Gene (2000)
- Proteins encoded by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3). Canaider, S., Facchin, F., Griffoni, C., Casadei, R., Vitale, L., Lenzi, L., Frabetti, F., D'Addabbo, P., Carinci, P., Zannotti, M., Strippoli, P. Gene (2006)
- A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. Rothermel, B., Vega, R.B., Yang, J., Wu, H., Bassel-Duby, R., Williams, R.S. J. Biol. Chem. (2000)
- DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Fuentes, J.J., Genescà, L., Kingsbury, T.J., Cunningham, K.W., Pérez-Riba, M., Estivill, X., de la Luna, S. Hum. Mol. Genet. (2000)
- VEGF selectively induces Down syndrome critical region 1 gene expression in endothelial cells: a mechanism for feedback regulation of angiogenesis? Yao, Y.G., Duh, E.J. Biochem. Biophys. Res. Commun. (2004)
- Down syndrome candidate region 1,a downstream target of VEGF, participates in endothelial cell migration and angiogenesis. Iizuka, M., Abe, M., Shiiba, K., Sasaki, I., Sato, Y. J. Vasc. Res. (2004)
- Raf-1 is a binding partner of DSCR1. Cho, Y.J., Abe, M., Kim, S.Y., Sato, Y. Arch. Biochem. Biophys. (2005)
- Thrombin-induced autoinhibitory factor, Down syndrome critical region-1, attenuates NFAT-dependent vascular cell adhesion molecule-1 expression and inflammation in the endothelium. Minami, T., Miura, M., Aird, W.C., Kodama, T. J. Biol. Chem. (2006)
- adapt78, a stress-inducible mRNA, is related to the glucose-regulated protein family of genes. Leahy, K.P., Davies, K.J., Dull, M., Kort, J.J., Lawrence, K.W., Crawford, D.R. Arch. Biochem. Biophys. (1999)
- Detection of two novel large deletions in SLC3A1 by semi-quantitative fluorescent multiplex PCR. Purroy, J., Bisceglia, L., Jaeken, J., Gasparini, P., Palacín, M., Nunes, V. Hum. Mutat. (2000)
- Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene. Fuentes, J.J., Pritchard, M.A., Estivill, X. Genomics (1997)