Gene Review:
EZH2 - enhancer of zeste 2 polycomb repressive...
Homo sapiens
Synonyms:
ENX-1, ENX1, EZH1, EZH2b, Enhancer of zeste homolog 2, ...
- The polycomb group protein EZH2 is involved in progression of prostate cancer. Varambally, S., Dhanasekaran, S.M., Zhou, M., Barrette, T.R., Kumar-Sinha, C., Sanda, M.G., Ghosh, D., Pienta, K.J., Sewalt, R.G., Otte, A.P., Rubin, M.A., Chinnaiyan, A.M. Nature (2002)
- SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Cao, R., Zhang, Y. Mol. Cell (2004)
- Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells. Reynolds, P.A., Sigaroudinia, M., Zardo, G., Wilson, M.B., Benton, G.M., Miller, C.J., Hong, C., Fridlyand, J., Costello, J.F., Tlsty, T.D. J. Biol. Chem. (2006)
- The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma. Visser, H.P., Gunster, M.J., Kluin-Nelemans, H.C., Manders, E.M., Raaphorst, F.M., Meijer, C.J., Willemze, R., Otte, A.P. Br. J. Haematol. (2001)
- A role for EZH2 in silencing of IFN-gamma inducible MHC2TA transcription in uveal melanoma. Holling, T.M., Bergevoet, M.W., Wilson, L., Van Eggermond, M.C., Schooten, E., Steenbergen, R.D., Snijders, P.J., Jager, M.J., Van den Elsen, P.J. J. Immunol. (2007)
- Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Schlesinger, Y., Straussman, R., Keshet, I., Farkash, S., Hecht, M., Zimmerman, J., Eden, E., Yakhini, Z., Ben-Shushan, E., Reubinoff, B.E., Bergman, Y., Simon, I., Cedar, H. Nat. Genet. (2007)
- pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4a tumor suppressor gene. Kotake, Y., Cao, R., Viatour, P., Sage, J., Zhang, Y., Xiong, Y. Genes Dev. (2007)
- Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Kirmizis, A., Bartley, S.M., Kuzmichev, A., Margueron, R., Reinberg, D., Green, R., Farnham, P.J. Genes Dev. (2004)
- EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. Bracken, A.P., Pasini, D., Capra, M., Prosperini, E., Colli, E., Helin, K. EMBO J. (2003)
- Activated p53 suppresses the histone methyltransferase EZH2 gene. Tang, X., Milyavsky, M., Shats, I., Erez, N., Goldfinger, N., Rotter, V. Oncogene (2004)
- Poorly differentiated breast carcinoma is associated with increased expression of the human polycomb group EZH2 gene. Raaphorst, F.M., Meijer, C.J., Fieret, E., Blokzijl, T., Mommers, E., Buerger, H., Packeisen, J., Sewalt, R.A., Otte, A.P., van Diest, P.J. Neoplasia (2003)
- Expression of Polycomb-group genes in human ovarian follicles, oocytes and preimplantation embryos. Hinkins, M., Huntriss, J., Miller, D., Picton, H.M. Reproduction (2005)
- Distinct BMI-1 and EZH2 expression patterns in thymocytes and mature T cells suggest a role for Polycomb genes in human T cell differentiation. Raaphorst, F.M., Otte, A.P., van Kemenade, F.J., Blokzijl, T., Fieret, E., Hamer, K.M., Satijn, D.P., Meijer, C.J. J. Immunol. (2001)
- Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer. Collett, K., Eide, G.E., Arnes, J., Stefansson, I.M., Eide, J., Braaten, A., Aas, T., Otte, A.P., Akslen, L.A. Clin. Cancer Res. (2006)
- Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. Pasini, D., Bracken, A.P., Jensen, M.R., Lazzerini Denchi, E., Helin, K. EMBO J. (2004)
- The polycomb group protein EZH2 is required for mammalian circadian clock function. Etchegaray, J.P., Yang, X., DeBruyne, J.P., Peters, A.H., Weaver, D.R., Jenuwein, T., Reppert, S.M. J. Biol. Chem. (2006)
- EZH2 promotes proliferation and invasiveness of prostate cancer cells. Bryant, R.J., Cross, N.A., Eaton, C.L., Hamdy, F.C., Cunliffe, V.T. Prostate (2007)
- Proliferative involvement of ENX-1, a putative human polycomb group gene, in haematopoietic cells. Fukuyama, T., Otsuka, T., Shigematsu, H., Uchida, N., Arima, F., Ohno, Y., Iwasaki, H., Fukuda, T., Niho, Y. Br. J. Haematol. (2000)
- Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins. Sewalt, R.G., Lachner, M., Vargas, M., Hamer, K.M., den Blaauwen, J.L., Hendrix, T., Melcher, M., Schweizer, D., Jenuwein, T., Otte, A.P. Mol. Cell. Biol. (2002)
- Multiplex biomarker approach for determining risk of prostate-specific antigen-defined recurrence of prostate cancer. Rhodes, D.R., Sanda, M.G., Otte, A.P., Chinnaiyan, A.M., Rubin, M.A. J. Natl. Cancer Inst. (2003)
- Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer. Chen, H., Tu, S.W., Hsieh, J.T. J. Biol. Chem. (2005)
- A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner. Attwooll, C., Oddi, S., Cartwright, P., Prosperini, E., Agger, K., Steensgaard, P., Wagener, C., Sardet, C., Moroni, M.C., Helin, K. J. Biol. Chem. (2005)
- Transcription factor E2F3 overexpressed in prostate cancer independently predicts clinical outcome. Foster, C.S., Falconer, A., Dodson, A.R., Norman, A.R., Dennis, N., Fletcher, A., Southgate, C., Dowe, A., Dearnaley, D., Jhavar, S., Eeles, R., Feber, A., Cooper, C.S. Oncogene (2004)
- EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Kleer, C.G., Cao, Q., Varambally, S., Shen, R., Ota, I., Tomlins, S.A., Ghosh, D., Sewalt, R.G., Otte, A.P., Hayes, D.F., Sabel, M.S., Livant, D., Weiss, S.J., Rubin, M.A., Chinnaiyan, A.M. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2. Chen, H., Rossier, C., Antonarakis, S.E. Genomics (1996)