Gene Review:
FKBP4 - FK506 binding protein 4, 59kDa
Homo sapiens
Synonyms:
51 kDa FK506-binding protein, 52 kDa FK506-binding protein, 52 kDa FKBP, 59 kDa immunophilin, FK506-binding protein 4, ...
- Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes. Peattie, D.A., Harding, M.W., Fleming, M.A., DeCenzo, M.T., Lippke, J.A., Livingston, D.J., Benasutti, M. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Human cyclophilin 40 is a heat shock protein that exhibits altered intracellular localization following heat shock. Mark, P.J., Ward, B.K., Kumar, P., Lahooti, H., Minchin, R.F., Ratajczak, T. Cell Stress Chaperones (2001)
- Studies of a co-chaperone of the androgen receptor, FKBP52, as candidate for hypospadias. Beleza-Meireles, A., Barbaro, M., Wedell, A., Töhönen, V., Nordenskjöld, A. Reprod. Biol. Endocrinol. (2007)
- A novel role for the immunophilin FKBP52 in copper transport. Sanokawa-Akakura, R., Dai, H., Akakura, S., Weinstein, D., Fajardo, J.E., Lang, S.E., Wadsworth, S., Siekierka, J., Birge, R.B. J. Biol. Chem. (2004)
- Adeno-associated virus type 2-mediated gene transfer: role of cellular FKBP52 protein in transgene expression. Qing, K., Hansen, J., Weigel-Kelley, K.A., Tan, M., Zhou, S., Srivastava, A. J. Virol. (2001)
- Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit. Schumm, K., Rocha, S., Caamano, J., Perkins, N.D. EMBO J. (2006)
- The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo. Riggs, D.L., Roberts, P.J., Chirillo, S.C., Cheung-Flynn, J., Prapapanich, V., Ratajczak, T., Gaber, R., Picard, D., Smith, D.F. EMBO J. (2003)
- Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506. Gold, B.G., Densmore, V., Shou, W., Matzuk, M.M., Gordon, H.S. J. Pharmacol. Exp. Ther. (1999)
- Estradiol-regulated expression of the immunophilins cyclophilin 40 and FKBP52 in MCF-7 breast cancer cells. Kumar, P., Mark, P.J., Ward, B.K., Minchin, R.F., Ratajczak, T. Biochem. Biophys. Res. Commun. (2001)
- Proteomic analysis and identification of new biomarkers and therapeutic targets for invasive ovarian cancer. Jones, M.B., Krutzsch, H., Shu, H., Zhao, Y., Liotta, L.A., Kohn, E.C., Petricoin, E.F. Proteomics (2002)
- Organization of the human FK506-binding immunophilin FKBP52 protein gene (FKBP4). Scammell, J.G., Hubler, T.R., Denny, W.B., Valentine, D.L. Genomics (2003)
- The immunophilin FKBP4 (FKBP52/FKBP59) maps to the distal short arm of human chromosome 12. Bermingham, N.A., Rauf, S., Katsanis, N., Martin, J.E., Hunter, A.J., Fisher, E.M. Mamm. Genome (1998)
- Wheat FKBP73 functions in vitro as a molecular chaperone independently of its peptidyl prolyl cis-trans isomerase activity. Kurek, I., Pirkl, F., Fischer, E., Buchner, J., Breiman, A. Planta (2002)
- The wheat peptidyl prolyl cis-trans-isomerase FKBP77 is heat induced and developmentally regulated. Kurek, I., Aviezer, K., Erel, N., Herman, E., Breiman, A. Plant Physiol. (1999)
- FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts. Smith, D.F., Albers, M.W., Schreiber, S.L., Leach, K.L., Deibel, M.R. J. Biol. Chem. (1993)
- Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin. Silverstein, A.M., Galigniana, M.D., Chen, M.S., Owens-Grillo, J.K., Chinkers, M., Pratt, W.B. J. Biol. Chem. (1997)
- Evidence that the peptidylprolyl isomerase domain of the hsp90-binding immunophilin FKBP52 is involved in both dynein interaction and glucocorticoid receptor movement to the nucleus. Galigniana, M.D., Radanyi, C., Renoir, J.M., Housley, P.R., Pratt, W.B. J. Biol. Chem. (2001)
- Immunosuppressor binding to the immunophilin FKBP59 affects the local structural dynamics of a surface beta-strand: time-resolved fluorescence study. Rouviere, N., Vincent, M., Craescu, C.T., Gallay, J. Biochemistry (1997)
- The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesis. Krummrei, U., Baulieu, E.E., Chambraud, B. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Association of immunophilins with mammalian TRPC channels. Sinkins, W.G., Goel, M., Estacion, M., Schilling, W.P. J. Biol. Chem. (2004)
- FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin. Chambraud, B., Radanyi, C., Camonis, J.H., Shazand, K., Rajkowski, K., Baulieu, E.E. J. Biol. Chem. (1996)
- The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13. Yem, A.W., Tomasselli, A.G., Heinrikson, R.L., Zurcher-Neely, H., Ruff, V.A., Johnson, R.A., Deibel, M.R. J. Biol. Chem. (1992)
- The hsp56 immunophilin component of steroid receptor heterocomplexes: could this be the elusive nuclear localization signal-binding protein? Pratt, W.B., Czar, M.J., Stancato, L.F., Owens, J.K. J. Steroid Biochem. Mol. Biol. (1993)
- The immunophilin FKBP52 inhibits the activity of the epithelial Ca2+ channel TRPV5. Gkika, D., Topala, C.N., Hoenderop, J.G., Bindels, R.J. Am. J. Physiol. Renal Physiol. (2006)
- Immunophilins, Refsum disease, and lupus nephritis: the peroxisomal enzyme phytanoyl-COA alpha-hydroxylase is a new FKBP-associated protein. Chambraud, B., Radanyi, C., Camonis, J.H., Rajkowski, K., Schumacher, M., Baulieu, E.E. Proc. Natl. Acad. Sci. U.S.A. (1999)
- FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells. Wochnik, G.M., Rüegg, J., Abel, G.A., Schmidt, U., Holsboer, F., Rein, T. J. Biol. Chem. (2005)
- The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52. Bruner, K.L., Derfoul, A., Robertson, N.M., Guerriero, G., Fernandes-Alnemri, T., Alnemri, E.S., Litwack, G. Receptors & signal transduction. (1997)
- Crystallization and preliminary crystallographic studies of the C-terminal domain of human FKBP52. Wu, B., Li, P., Shu, C., Shen, B., Rao, Z. Acta Crystallogr. D Biol. Crystallogr. (2003)
- Three-step purification of a fragment of the large immunophilin FKBP52. Pirkl, F. J. Chromatogr. B Biomed. Sci. Appl. (2000)
- Neuroimmunophilin ligands: evaluation of their therapeutic potential for the treatment of neurological disorders. Gold, B.G. Expert opinion on investigational drugs. (2000)
- Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH. Marinoni, J.C., Roy, R., Vermeulen, W., Miniou, P., Lutz, Y., Weeda, G., Seroz, T., Gomez, D.M., Hoeijmakers, J.H., Egly, J.M. EMBO J. (1997)