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Gene Review

RHOB  -  ras homolog family member B

Homo sapiens

Synonyms: ARH6, ARHB, MST081, MSTP081, RHOH6, ...
 
 
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Disease relevance of RHOB

 

High impact information on RHOB

 

Chemical compound and disease context of RHOB

  • Androgen control of cell proliferation and cytoskeletal reorganization in human fibrosarcoma cells: role of RhoB signaling [8].
  • Earlier studies have shown that the C-terminal half of helix 6 (H6) of the influenza A virus matrix protein (M1) containing the YRKL sequence is involved in virus budding (E. K.-W. Hui, S. Barman, T. Y. Yang, and D. P. Nayak, J. Virol. 77:7078-7092, 2003) [9].
 

Biological context of RHOB

 

Anatomical context of RHOB

 

Associations of RHOB with chemical compounds

  • Finally, Ras-mediated resistance to 5-FU-induced apoptosis is reversed by RhoB [16].
  • Among other genes, the small GTPase RhoB was found to be significantly upregulated by TPX and repressed by HDAC1 [15].
  • Palmitoylated cysteine 192 is required for RhoB tumor-suppressive and apoptotic activities [17].
  • Although depletion of mevalonate does not alter steady state levels of Ras mRNA, there is an increase in RhoB mRNA [18].
  • Mutation of cysteine 192 to glycine, alanine, or serine blocks the ability of RhoB to suppress transforming growth factor beta type II receptor, p2lwaf, and AP-1 promoter transcriptional activities [17].
  • Loss of RhoB prevents Streptozotocin induced beta cell loss  
 

Physical interactions of RHOB

  • Electrophoretic mobility shift assays clearly showed that the binding of AP1 to its DNA-binding site is strongly inhibited by RhoB [19].
  • The RhoB-binding domain in DB1 was located in a functionally undefined region upstream and separable from its zinc finger DNA binding domain [20].
 

Regulatory relationships of RHOB

  • Consequently, transcription assays using an AP1 reporter showed that AP1-mediated transcription is down-regulated by RhoB [19].
  • These results demonstrate that the Ras/Erk and the Ras/RhoA pathways negatively regulate whereas RhoB enhances cytokine-induced NOS-2 [21].
  • Transient expression of dominant-negative mutants of RhoA and RhoB induced a significant increased in CD36 promoter activity [22].
  • Ras and RhoA suppress whereas RhoB enhances cytokine-induced transcription of nitric oxide synthase-2 in human normal liver AKN-1 cells and lung cancer A-549 cells [21].
  • Rhophilin-2 is targeted to late-endosomal structures of the vesicular machinery in the presence of activated RhoB [23].
 

Other interactions of RHOB

  • Inhibition of UVB-induced EGFR activation prevents RhoB protein expression and AKT phosphorylation but not the early activation of RhoB [10].
  • RhoB is involved in epidermal growth factor (EGF) receptor trafficking, cytoskeletal organization, cell transformation, and survival [10].
  • RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG [11].
  • Our data suggest that p76RBE could play a key role between RhoB and potential downstream elements needed under stimulation of the thyrotropin/cAMP pathway in thyrocytes and responsible for intracellular motile phenomena such as the endocytosis involved in the thyroid secretory process [24].
  • Cdc42 and RhoB activation are required for mannose receptor-mediated phagocytosis by human alveolar macrophages [25].
 

Analytical, diagnostic and therapeutic context of RHOB

 

 

References

  1. Loss of RhoB expression in human lung cancer progression. Mazieres, J., Antonia, T., Daste, G., Muro-Cacho, C., Berchery, D., Tillement, V., Pradines, A., Sebti, S., Favre, G. Clin. Cancer Res. (2004) [Pubmed]
  2. Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB. Gerhard, R., Tatge, H., Genth, H., Thum, T., Borlak, J., Fritz, G., Just, I. J. Biol. Chem. (2005) [Pubmed]
  3. Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter. Delarue, F.L., Adnane, J., Joshi, B., Blaskovich, M.A., Wang, D.A., Hawker, J., Bizouarn, F., Ohkanda, J., Zhu, K., Hamilton, A.D., Chellappan, S., Sebti, S.M. Oncogene (2007) [Pubmed]
  4. Suppression of rho B expression in invasive carcinoma from head and neck cancer patients. Adnane, J., Muro-Cacho, C., Mathews, L., Sebti, S.M., Muñoz-Antonia, T. Clin. Cancer Res. (2002) [Pubmed]
  5. Classification and prediction of survival in patients with the leukemic phase of cutaneous T cell lymphoma. Kari, L., Loboda, A., Nebozhyn, M., Rook, A.H., Vonderheid, E.C., Nichols, C., Virok, D., Chang, C., Horng, W.H., Johnston, J., Wysocka, M., Showe, M.K., Showe, L.C. J. Exp. Med. (2003) [Pubmed]
  6. TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation. Kamon, H., Kawabe, T., Kitamura, H., Lee, J., Kamimura, D., Kaisho, T., Akira, S., Iwamatsu, A., Koga, H., Murakami, M., Hirano, T. EMBO J. (2006) [Pubmed]
  7. Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding. Michaelson, D., Silletti, J., Murphy, G., D'Eustachio, P., Rush, M., Philips, M.R. J. Cell Biol. (2001) [Pubmed]
  8. Androgen control of cell proliferation and cytoskeletal reorganization in human fibrosarcoma cells: role of RhoB signaling. Chauhan, S., Kunz, S., Davis, K., Roberts, J., Martin, G., Demetriou, M.C., Sroka, T.C., Cress, A.E., Miesfeld, R.L. J. Biol. Chem. (2004) [Pubmed]
  9. YRKL sequence of influenza virus M1 functions as the L domain motif and interacts with VPS28 and Cdc42. Hui, E.K., Barman, S., Tang, D.H., France, B., Nayak, D.P. J. Virol. (2006) [Pubmed]
  10. RhoB protects human keratinocytes from UVB-induced apoptosis through epidermal growth factor receptor signaling. Canguilhem, B., Pradines, A., Baudouin, C., Boby, C., Lajoie-Mazenc, I., Charveron, M., Favre, G. J. Biol. Chem. (2005) [Pubmed]
  11. RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG. Zalcman, G., Closson, V., Camonis, J., Honoré, N., Rousseau-Merck, M.F., Tavitian, A., Olofsson, B. J. Biol. Chem. (1996) [Pubmed]
  12. A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells. Wang, L., Yang, L., Luo, Y., Zheng, Y. J. Biol. Chem. (2003) [Pubmed]
  13. Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB. Gampel, A., Parker, P.J., Mellor, H. Curr. Biol. (1999) [Pubmed]
  14. RhoB regulates endosome transport by promoting actin assembly on endosomal membranes through Dia1. Fernandez-Borja, M., Janssen, L., Verwoerd, D., Hordijk, P., Neefjes, J. J. Cell. Sci. (2005) [Pubmed]
  15. Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line. Wang, S., Yan-Neale, Y., Fischer, D., Zeremski, M., Cai, R., Zhu, J., Asselbergs, F., Hampton, G., Cohen, D. Oncogene (2003) [Pubmed]
  16. EGFR, ErbB2 and Ras but not Src suppress RhoB expression while ectopic expression of RhoB antagonizes oncogene-mediated transformation. Jiang, K., Delarue, F.L., Sebti, S.M. Oncogene (2004) [Pubmed]
  17. Palmitoylated cysteine 192 is required for RhoB tumor-suppressive and apoptotic activities. Wang, D.A., Sebti, S.M. J. Biol. Chem. (2005) [Pubmed]
  18. Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB. Holstein, S.A., Wohlford-Lenane, C.L., Hohl, R.J. J. Biol. Chem. (2002) [Pubmed]
  19. RhoB, not RhoA, represses the transcription of the transforming growth factor beta type II receptor by a mechanism involving activator protein 1. Adnane, J., Seijo, E., Chen, Z., Bizouarn, F., Leal, M., Sebti, S.M., Muñoz-Antonia, T. J. Biol. Chem. (2002) [Pubmed]
  20. Functional interaction between RhoB and the transcription factor DB1. Lebowitz, P.F., Prendergast, G.C. Cell Adhes. Commun. (1998) [Pubmed]
  21. Ras and RhoA suppress whereas RhoB enhances cytokine-induced transcription of nitric oxide synthase-2 in human normal liver AKN-1 cells and lung cancer A-549 cells. Delarue, F.L., Taylor, B.S., Sebti, S.M. Oncogene (2001) [Pubmed]
  22. Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression. Ruiz-Velasco, N., Domínguez, A., Vega, M.A. Biochem. Pharmacol. (2004) [Pubmed]
  23. Rhophilin-2 is targeted to late-endosomal structures of the vesicular machinery in the presence of activated RhoB. Steuve, S., Devosse, T., Lauwers, E., Vanderwinden, J.M., Andr??, B., Courtoy, P.J., Pirson, I. Exp. Cell Res. (2006) [Pubmed]
  24. Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP. Mircescu, H., Steuve, S., Savonet, V., Degraef, C., Mellor, H., Dumont, J.E., Maenhaut, C., Pirson, I. Eur. J. Biochem. (2002) [Pubmed]
  25. Cdc42 and RhoB activation are required for mannose receptor-mediated phagocytosis by human alveolar macrophages. Zhang, J., Zhu, J., Bu, X., Cushion, M., Kinane, T.B., Avraham, H., Koziel, H. Mol. Biol. Cell (2005) [Pubmed]
  26. RhoB is frequently downregulated in non-small-cell lung cancer and resides in the 2p24 homozygous deletion region of a lung cancer cell line. Sato, N., Fukui, T., Taniguchi, T., Yokoyama, T., Kondo, M., Nagasaka, T., Goto, Y., Gao, W., Ueda, Y., Yokoi, K., Minna, J.D., Osada, H., Kondo, Y., Sekido, Y. Int. J. Cancer (2007) [Pubmed]
  27. Subcellular localization of the GTP-binding protein Rho in the sea urchin sperm. Castellano, L.E., Martínez-Cadena, G., López-Godínez, J., Obregón, A., García-Soto, J. Eur. J. Cell Biol. (1997) [Pubmed]
 
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