Gene Review:
PAM - peptidylglycine alpha-amidating monooxygenase
Homo sapiens
Synonyms:
PAL, PHM, Peptidyl-glycine alpha-amidating monooxygenase
- Peptide amidating activity in human bronchoalveolar lavage fluid. Scott, F.M., Treston, A.M., Shaw, G.L., Avis, I., Sorenson, J., Kelly, K., Dempsey, E.C., Cantor, A.B., Tockman, M., Mulshine, J.L. Lung Cancer (1996)
- Expression in human lung cancer cell lines of genes of prohormone processing and the neuroendocrine phenotype. Vos, M.D., Scott, F.M., Iwai, N., Treston, A.M. J. Cell. Biochem. Suppl. (1996)
- Neutralization of adrenomedullin inhibits the growth of human glioblastoma cell lines in vitro and suppresses tumor xenograft growth in vivo. Ouafik, L., Sauze, S., Boudouresque, F., Chinot, O., Delfino, C., Fina, F., Vuaroqueaux, V., Dussert, C., Palmari, J., Dufour, H., Grisoli, F., Casellas, P., Brünner, N., Martin, P.M. Am. J. Pathol. (2002)
- Expression of adrenomedullin and peptide amidation activity in human prostate cancer and in human prostate cancer cell lines. Rocchi, P., Boudouresque, F., Zamora, A.J., Muracciole, X., Lechevallier, E., Martin, P.M., Ouafik, L. Cancer Res. (2001)
- Peptide alpha-amidation activity in human plasma: relationship to gastrin processing. Kapuscinski, M., Green, M., Sinha, S.N., Shepherd, J.J., Shulkes, A. Clin. Endocrinol. (Oxf) (1993)
- Alzheimer's disease: low levels of peptide alpha-amidation activity in brain and CSF. Wand, G.S., May, C., May, V., Whitehouse, P.J., Rapoport, S.I., Eipper, B.A. Neurology (1987)
- Effects of eye rotation on the sound-evoked post-auricular muscle response (PAMR). Patuzzi, R.B., O'Beirne, G.A. Hear. Res. (1999)
- Penicillin levels in blood and CSF achieved by treatment of syphilis. Dunlop, E.M., Al-Egaily, S.S., Houang, E.T. JAMA (1979)
- COOH-terminal signals mediate the trafficking of a peptide processing enzyme in endocrine cells. Milgram, S.L., Mains, R.E., Eipper, B.A. J. Cell Biol. (1993)
- Reversal of the transformed phenotype and inhibition of peptidylglycine alpha-monooxygenase in Ras-transformed cells by 4-phenyl-3-butenoic acid. Sunman, J.A., Foster, M.S., Folse, S.L., May, S.W., Matesic, D.F. Mol. Carcinog. (2004)
- Acid-base status in dietary treatment of phenylketonuria. Manz, F., Schmidt, H., Schärer, K., Bickel, H. Pediatr. Res. (1977)
- The combination of cisplatin, doxorubicin, and mitomycin (PAM) compared with the FAM regimen in treating advanced gastric carcinoma. A phase II randomized trial of the Italian Oncology Group for Clinical Research. De Lisi, V., Cocconi, G., Angelini, F., Cavicchi, F., Di Costanzo, F., Gilli, G., Rodinò, C., Soldani, M., Tonato, M., Finardi, C. Cancer (1996)
- Neoadjuvant chemotherapy with cisplatin, aclacinomycin A, and mitomycin C for cervical adenocarcinoma--a preliminary study. Saito, T., Takehara, M., Lee, R., Fujimoto, T., Nishimura, M., Tanaka, R., Ito, E., Adachi, K., Kudo, R. Int. J. Gynecol. Cancer (2004)
- Photo-cross-linked hydrogels with polysaccharide-poly(amino acid) structure: new biomaterials for pharmaceutical applications. Pitarresi, G., Pierro, P., Palumbo, F.S., Tripodo, G., Giammona, G. Biomacromolecules (2006)
- Mammalian peptidylglycine alpha-amidating monooxygenase mRNA expression can be modulated by the La autoantigen. Brenet, F., Dussault, N., Borch, J., Ferracci, G., Delfino, C., Roepstorff, P., Miquelis, R., Ouafik, L. Mol. Cell. Biol. (2005)
- Supplying copper to the cuproenzyme peptidylglycine alpha-amidating monooxygenase. El Meskini, R., Culotta, V.C., Mains, R.E., Eipper, B.A. J. Biol. Chem. (2003)
- Identification of a neuropeptide and neuropeptide-processing enzymes in aqueous humor confers neuroendocrine features to the human ocular ciliary epithelium. Ortego, J., Escribano, J., Crabb, J., Coca-Prados, M. J. Neurochem. (1996)
- Immunocytochemical finding of the amidating enzymes in mouse pancreatic A-, B-, and D-cells: a comparison with human and rat. Garmendia, O., Rodríguez, M.P., Burrell, M.A., Villaro, A.C. J. Histochem. Cytochem. (2002)
- Androgen-independent expression of adrenomedullin and peptidylglycine alpha-amidating monooxygenase in human prostatic carcinoma. Jiménez, N., Abasolo, I., Jongsma, J., Calvo, A., Garayoa, M., van der Kwast, T.H., van Steenbrugge, G.J., Montuenga, L.M. Mol. Carcinog. (2003)
- Isolation and functional expression of human pancreatic peptidylglycine alpha-amidating monooxygenase. Tateishi, K., Arakawa, F., Misumi, Y., Treston, A.M., Vos, M., Matsuoka, Y. Biochem. Biophys. Res. Commun. (1994)
- Mononuclear copper active-oxygen complexes. Itoh, S. Current opinion in chemical biology. (2006)
- Alternative splicing governs sulfation of tyrosine or oligosaccharide on peptidylglycine alpha-amidating monooxygenase. Yun, H.Y., Keutmann, H.T., Eipper, B.A. J. Biol. Chem. (1994)
- The maintenance of high affinity plasminogen binding by group A streptococcal plasminogen-binding M-like protein is mediated by arginine and histidine residues within the a1 and a2 repeat domains. Sanderson-Smith, M.L., Walker, M.J., Ranson, M. J. Biol. Chem. (2006)
- Access of a membrane protein to secretory granules is facilitated by phosphorylation. Steveson, T.C., Zhao, G.C., Keutmann, H.T., Mains, R.E., Eipper, B.A. J. Biol. Chem. (2001)
- Signaling mediated by the cytosolic domain of peptidylglycine alpha-amidating monooxygenase. Alam, M.R., Steveson, T.C., Johnson, R.C., Bäck, N., Abraham, B., Mains, R.E., Eipper, B.A. Mol. Biol. Cell (2001)
- Increased neuropeptide Y-immunoreactive innervation of aganglionic bowel in Hirschsprung's disease. Hamada, Y., Bishop, A.E., Federici, G., Rivosecchi, M., Talbot, I.C., Polak, J.M. Virchows Archiv. A, Pathological anatomy and histopathology. (1987)
- Localization of integral membrane peptidylglycine alpha-amidating monooxygenase in neuroendocrine cells. Milgram, S.L., Kho, S.T., Martin, G.V., Mains, R.E., Eipper, B.A. J. Cell. Sci. (1997)
- The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha-amidating monooxygenase. Caldwell, B.D., Darlington, D.N., Penzes, P., Johnson, R.C., Eipper, B.A., Mains, R.E. J. Biol. Chem. (1999)