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CCL13  -  chemokine (C-C motif) ligand 13

Homo sapiens

Synonyms: C-C motif chemokine 13, CK-beta-10, CKb10, MCP-4, MCP4, ...
 
 
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Disease relevance of CCL13

 

High impact information on CCL13

 

Chemical compound and disease context of CCL13

  • CONCLUSION: Our results demonstrate that allergen-induced rhinitis is associated with an increased expression of MCP-3 and MCP-4, which may be closely related to the influx of inflammatory cells and may thus contribute to the pathogenesis of allergic rhinitis [9].
  • The latter effect of aldosterone was due to an effect on the cytomegalovirus promoter/enhancer driving the expression of hNCC. hNCC-MDCK cells are a good model for the study of the regulation of apical trafficking and ion-transporting activity of hNCC [10].
 

Biological context of CCL13

 

Anatomical context of CCL13

 

Associations of CCL13 with chemical compounds

 

Physical interactions of CCL13

  • Individuals bearing haplotypic variants of the MCP-4 core promoter that avidly bind the transcription factor YY-1 had higher plasma levels of MCP-4 than did individuals with variants with lower binding avidity (490, 360, and 360 pg/ml; P < 0.01) [21].
 

Regulatory relationships of CCL13

  • In support of our in situ findings demonstrating MCP-4 expression in epithelial cells and mononuclear cells in vivo, we have found that MCP-4 expression can be induced in these cells in vitro by tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) [22].
  • Increasing doses of a YY-1 expression vector induced significantly greater reporter activity from MCP-4 core promoter expression constructs of the wild-type compared with the variant sequence in transient transfection experiments [21].
  • The expression of eotaxin and MCP-4 was enhanced in eosinophils following IL-5 treatment [23].
  • Monocyte chemoattractant protein-4 (MCP-4)/CCL13 is highly expressed in cartilage from patients with rheumatoid arthritis [24].
  • In contrast to other prominent cytokines involved in the pathogenesis of RA, OSM can strongly up-regulate the expression of CCL13, a chemokine recently identified in the synovial fluid of patients with RA [25].
 

Other interactions of CCL13

 

Analytical, diagnostic and therapeutic context of CCL13

  • Genomic organization, sequence analysis and transcriptional regulation of the human MCP-4 chemokine gene (SCYA13) in dermal fibroblasts: a comparison to other eosinophilic beta-chemokines [12].
  • MCP-4 mRNA was found in cells collected in bronchoalveolar lavage of asthmatic and nonasthmatic subjects and was prominently expressed in human lung and heart [8].
  • RESULTS: Serum MCP-4 levels showed positive correlation with BMI (r = 0.318, p = 0.014), waist (r = 0.316, p = 0.018), and waist-to-hip ratio (WHR) (r = 0.264, p = 0.049) [30].
  • Western blot testing revealed that the cells predominantly expressed the complex glycosylated (approximately 140 kD) form of hNCC. hNCC was present primarily in the apical part of the cell [10].
  • At the same concentration range SPD and tamoxifen did not inhibit the proliferation of normal human liver cell line CCL 13 and normal bovine kidney MDBK; whereas adriamycin, a common chemotherapy drug for the treatment of advance cancer, caused 95% inhibition at 10(-6) M [31].

References

  1. Potential role for monocyte chemotactic protein-4 (MCP-4) in monocyte/macrophage recruitment in acute renal inflammation. Chakravorty, S.J., Howie, A.J., Girdlestone, J., Gentle, D., Savage, C.O. J. Pathol. (2001) [Pubmed]
  2. Eotaxin and monocyte chemotactic protein-4 mRNA expression in small airways of asthmatic and nonasthmatic individuals. Taha, R.A., Minshall, E.M., Miotto, D., Shimbara, A., Luster, A., Hogg, J.C., Hamid, Q.A. J. Allergy Clin. Immunol. (1999) [Pubmed]
  3. Glucocorticosteroids inhibit mRNA expression for eotaxin, eotaxin-2, and monocyte-chemotactic protein-4 in human airway inflammation with eosinophilia. Jahnsen, F.L., Haye, R., Gran, E., Brandtzaeg, P., Johansen, F.E. J. Immunol. (1999) [Pubmed]
  4. Evidence for increased expression of eotaxin and monocyte chemotactic protein-4 in atopic dermatitis. Taha, R.A., Minshall, E.M., Leung, D.Y., Boguniewicz, M., Luster, A., Muro, S., Toda, M., Hamid, Q.A. J. Allergy Clin. Immunol. (2000) [Pubmed]
  5. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. Patel, V.P., Kreider, B.L., Li, Y., Li, H., Leung, K., Salcedo, T., Nardelli, B., Pippalla, V., Gentz, S., Thotakura, R., Parmelee, D., Gentz, R., Garotta, G. J. Exp. Med. (1997) [Pubmed]
  6. Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. Uguccioni, M., Loetscher, P., Forssmann, U., Dewald, B., Li, H., Lima, S.H., Li, Y., Kreider, B., Garotta, G., Thelen, M., Baggiolini, M. J. Exp. Med. (1996) [Pubmed]
  7. High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines. Uguccioni, M., Mackay, C.R., Ochensberger, B., Loetscher, P., Rhis, S., LaRosa, G.J., Rao, P., Ponath, P.D., Baggiolini, M., Dahinden, C.A. J. Clin. Invest. (1997) [Pubmed]
  8. Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines. Stellato, C., Collins, P., Ponath, P.D., Soler, D., Newman, W., La Rosa, G., Li, H., White, J., Schwiebert, L.M., Bickel, C., Liu, M., Bochner, B.S., Williams, T., Schleimer, R.P. J. Clin. Invest. (1997) [Pubmed]
  9. Monocyte chemotactic proteins in allergen-induced inflammation in the nasal mucosa: effect of topical corticosteroids. Christodoulopoulos, P., Wright, E., Frenkiel, S., Luster, A., Hamid, Q. J. Allergy Clin. Immunol. (1999) [Pubmed]
  10. Functional expression of the human thiazide-sensitive NaCl cotransporter in Madin-Darby canine kidney cells. de Jong, J.C., Willems, P.H., van den Heuvel, L.P., Knoers, N.V., Bindels, R.J. J. Am. Soc. Nephrol. (2003) [Pubmed]
  11. Proteoglycans are potent modulators of the biological responses of eosinophils to chemokines. Culley, F.J., Fadlon, E.J., Kirchem, A., Williams, T.J., Jose, P.J., Pease, J.E. Eur. J. Immunol. (2003) [Pubmed]
  12. Genomic organization, sequence analysis and transcriptional regulation of the human MCP-4 chemokine gene (SCYA13) in dermal fibroblasts: a comparison to other eosinophilic beta-chemokines. Hein, H., Schlüter, C., Kulke, R., Christophers, E., Schröder, J.M., Bartels, J. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  13. The carboxyl terminus of the chemokine receptor CCR3 contains distinct domains which regulate chemotactic signaling and receptor down-regulation in a ligand-dependent manner. Sabroe, I., Jorritsma, A., Stubbs, V.E., Xanthou, G., Jopling, L.A., Ponath, P.D., Williams, T.J., Murphy, P.M., Pease, J.E. Eur. J. Immunol. (2005) [Pubmed]
  14. Detection of MCP-4 in dermal fibroblasts and its activation of the respiratory burst in human eosinophils. Petering, H., Höchstetter, R., Kimmig, D., Smolarski, R., Kapp, A., Elsner, J. J. Immunol. (1998) [Pubmed]
  15. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. White, J.R., Lee, J.M., Dede, K., Imburgia, C.S., Jurewicz, A.J., Chan, G., Fornwald, J.A., Dhanak, D., Christmann, L.T., Darcy, M.G., Widdowson, K.L., Foley, J.J., Schmidt, D.B., Sarau, H.M. J. Biol. Chem. (2000) [Pubmed]
  16. Monocyte chemotactic protein-4: tissue-specific expression and signaling through CC chemokine receptor-2. Godiska, R., Chantry, D., Raport, C.J., Schweickart, V.L., Trong, H.L., Gray, P.W. J. Leukoc. Biol. (1997) [Pubmed]
  17. IL-4 differentially regulates eotaxin and MCP-4 in lung epithelium and circulating mononuclear cells. Nakamura, H., Luster, A.D., Tateno, H., Jedrzkiewicz, S., Tamura, G., Haley, K.J., Garcia-Zepeda, E.A., Yamaguchi, K., Lilly, C.M. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  18. Apoptotic condensations in M-phase cells. Sit, K.H., Yin, L., Paramanantham, R. Anat. Rec. (1997) [Pubmed]
  19. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. Garcia-Zepeda, E.A., Combadiere, C., Rothenberg, M.E., Sarafi, M.N., Lavigne, F., Hamid, Q., Murphy, P.M., Luster, A.D. J. Immunol. (1996) [Pubmed]
  20. The monocyte chemotactic protein-4 induces oxygen radical production, actin reorganization, and CD11b up-regulation via a pertussis toxin-sensitive G-protein in human eosinophils. Tenscher, K., Metzner, B., Hofmann, C., Schöpf, E., Norgauer, J. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  21. Monocyte chemoattractant protein-4 core promoter genetic variants: influence on YY-1 affinity and plasma levels. Kalayci, O., Birben, E., Wu, L., Oguma, T., Storm Van's Gravesande, K., Subramaniam, V., Sheldon, H.K., Silverman, E.S., Lilly, C.M. Am. J. Respir. Cell Mol. Biol. (2003) [Pubmed]
  22. Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines. Lamkhioued, B., Garcia-Zepeda, E.A., Abi-Younes, S., Nakamura, H., Jedrzkiewicz, S., Wagner, L., Renzi, P.M., Allakhverdi, Z., Lilly, C., Hamid, Q., Luster, A.D. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  23. Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines. Gounni Abdelilah, S., Wellemans, V., Agouli, M., Guenounou, M., Hamid, Q., Beck, L.A., Lamkhioued, B. Clin. Immunol. (2006) [Pubmed]
  24. Monocyte chemoattractant protein-4 (MCP-4)/CCL13 is highly expressed in cartilage from patients with rheumatoid arthritis. Iwamoto, T., Okamoto, H., Iikuni, N., Takeuchi, M., Toyama, Y., Tomatsu, T., Kamatani, N., Momohara, S. Rheumatology (Oxford, England) (2006) [Pubmed]
  25. Induction of CCL13 expression in synovial fibroblasts highlights a significant role of oncostatin M in rheumatoid arthritis. Hintzen, C., Quaiser, S., Pap, T., Heinrich, P.C., Hermanns, H.M. Arthritis Rheum. (2009) [Pubmed]
  26. Differential regulation of epithelial-derived C-C chemokine expression by IL-4 and the glucocorticoid budesonide. Stellato, C., Matsukura, S., Fal, A., White, J., Beck, L.A., Proud, D., Schleimer, R.P. J. Immunol. (1999) [Pubmed]
  27. C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES). Ying, S., Robinson, D.S., Meng, Q., Barata, L.T., McEuen, A.R., Buckley, M.G., Walls, A.F., Askenase, P.W., Kay, A.B. J. Immunol. (1999) [Pubmed]
  28. Increased expression of the chemoattractant cytokines eotaxin, monocyte chemotactic protein-4, and interleukin-16 in induced sputum in asthmatic patients. Taha, R.A., Laberge, S., Hamid, Q., Olivenstein, R. Chest (2001) [Pubmed]
  29. Chemokines and CD40 expression in human fibroblasts. Brouty-Boyé, D., Pottin-Clémenceau, C., Doucet, C., Jasmin, C., Azzarone, B. Eur. J. Immunol. (2000) [Pubmed]
  30. Elevated serum monocyte chemoattractant protein-4 and chronic inflammation in overweight subjects. Hashimoto, I., Wada, J., Hida, A., Baba, M., Miyatake, N., Eguchi, J., Shikata, K., Makino, H. Obesity (Silver Spring, Md.) (2006) [Pubmed]
  31. Non-steroid receptor-mediated antiproliferative activity of styrylpyrone derivative in human breast cancer cell lines. Pihie, A.H., Stanslas, J., Din, L.B. Anticancer Res. (1998) [Pubmed]
 
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