Gene Review:
CCL13 - chemokine (C-C motif) ligand 13
Homo sapiens
Synonyms:
C-C motif chemokine 13, CK-beta-10, CKb10, MCP-4, MCP4, ...
Fal,
Doucet,
Fornwald,
Pease,
Stellato,
Culley,
Schleimer,
Proud,
Azzarone,
Dhanak,
Matsukura,
White,
Jasmin,
Sarau,
Foley,
Widdowson,
Schmidt,
Darcy,
Brouty-Boyé,
Lee,
Beck,
Johansen,
Imburgia,
Jose,
Williams,
Jahnsen,
Haye,
Chan,
Dede,
Gran,
Brandtzaeg,
Pottin-Clémenceau,
Jurewicz,
White,
Christmann,
Fadlon,
Kirchem,
- Potential role for monocyte chemotactic protein-4 (MCP-4) in monocyte/macrophage recruitment in acute renal inflammation. Chakravorty, S.J., Howie, A.J., Girdlestone, J., Gentle, D., Savage, C.O. J. Pathol. (2001)
- Eotaxin and monocyte chemotactic protein-4 mRNA expression in small airways of asthmatic and nonasthmatic individuals. Taha, R.A., Minshall, E.M., Miotto, D., Shimbara, A., Luster, A., Hogg, J.C., Hamid, Q.A. J. Allergy Clin. Immunol. (1999)
- Glucocorticosteroids inhibit mRNA expression for eotaxin, eotaxin-2, and monocyte-chemotactic protein-4 in human airway inflammation with eosinophilia. Jahnsen, F.L., Haye, R., Gran, E., Brandtzaeg, P., Johansen, F.E. J. Immunol. (1999)
- Evidence for increased expression of eotaxin and monocyte chemotactic protein-4 in atopic dermatitis. Taha, R.A., Minshall, E.M., Leung, D.Y., Boguniewicz, M., Luster, A., Muro, S., Toda, M., Hamid, Q.A. J. Allergy Clin. Immunol. (2000)
- Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. Patel, V.P., Kreider, B.L., Li, Y., Li, H., Leung, K., Salcedo, T., Nardelli, B., Pippalla, V., Gentz, S., Thotakura, R., Parmelee, D., Gentz, R., Garotta, G. J. Exp. Med. (1997)
- Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. Uguccioni, M., Loetscher, P., Forssmann, U., Dewald, B., Li, H., Lima, S.H., Li, Y., Kreider, B., Garotta, G., Thelen, M., Baggiolini, M. J. Exp. Med. (1996)
- High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines. Uguccioni, M., Mackay, C.R., Ochensberger, B., Loetscher, P., Rhis, S., LaRosa, G.J., Rao, P., Ponath, P.D., Baggiolini, M., Dahinden, C.A. J. Clin. Invest. (1997)
- Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines. Stellato, C., Collins, P., Ponath, P.D., Soler, D., Newman, W., La Rosa, G., Li, H., White, J., Schwiebert, L.M., Bickel, C., Liu, M., Bochner, B.S., Williams, T., Schleimer, R.P. J. Clin. Invest. (1997)
- Monocyte chemotactic proteins in allergen-induced inflammation in the nasal mucosa: effect of topical corticosteroids. Christodoulopoulos, P., Wright, E., Frenkiel, S., Luster, A., Hamid, Q. J. Allergy Clin. Immunol. (1999)
- Functional expression of the human thiazide-sensitive NaCl cotransporter in Madin-Darby canine kidney cells. de Jong, J.C., Willems, P.H., van den Heuvel, L.P., Knoers, N.V., Bindels, R.J. J. Am. Soc. Nephrol. (2003)
- Proteoglycans are potent modulators of the biological responses of eosinophils to chemokines. Culley, F.J., Fadlon, E.J., Kirchem, A., Williams, T.J., Jose, P.J., Pease, J.E. Eur. J. Immunol. (2003)
- Genomic organization, sequence analysis and transcriptional regulation of the human MCP-4 chemokine gene (SCYA13) in dermal fibroblasts: a comparison to other eosinophilic beta-chemokines. Hein, H., Schlüter, C., Kulke, R., Christophers, E., Schröder, J.M., Bartels, J. Biochem. Biophys. Res. Commun. (1999)
- The carboxyl terminus of the chemokine receptor CCR3 contains distinct domains which regulate chemotactic signaling and receptor down-regulation in a ligand-dependent manner. Sabroe, I., Jorritsma, A., Stubbs, V.E., Xanthou, G., Jopling, L.A., Ponath, P.D., Williams, T.J., Murphy, P.M., Pease, J.E. Eur. J. Immunol. (2005)
- Detection of MCP-4 in dermal fibroblasts and its activation of the respiratory burst in human eosinophils. Petering, H., Höchstetter, R., Kimmig, D., Smolarski, R., Kapp, A., Elsner, J. J. Immunol. (1998)
- Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. White, J.R., Lee, J.M., Dede, K., Imburgia, C.S., Jurewicz, A.J., Chan, G., Fornwald, J.A., Dhanak, D., Christmann, L.T., Darcy, M.G., Widdowson, K.L., Foley, J.J., Schmidt, D.B., Sarau, H.M. J. Biol. Chem. (2000)
- Monocyte chemotactic protein-4: tissue-specific expression and signaling through CC chemokine receptor-2. Godiska, R., Chantry, D., Raport, C.J., Schweickart, V.L., Trong, H.L., Gray, P.W. J. Leukoc. Biol. (1997)
- IL-4 differentially regulates eotaxin and MCP-4 in lung epithelium and circulating mononuclear cells. Nakamura, H., Luster, A.D., Tateno, H., Jedrzkiewicz, S., Tamura, G., Haley, K.J., Garcia-Zepeda, E.A., Yamaguchi, K., Lilly, C.M. Am. J. Physiol. Lung Cell Mol. Physiol. (2001)
- Apoptotic condensations in M-phase cells. Sit, K.H., Yin, L., Paramanantham, R. Anat. Rec. (1997)
- Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. Garcia-Zepeda, E.A., Combadiere, C., Rothenberg, M.E., Sarafi, M.N., Lavigne, F., Hamid, Q., Murphy, P.M., Luster, A.D. J. Immunol. (1996)
- The monocyte chemotactic protein-4 induces oxygen radical production, actin reorganization, and CD11b up-regulation via a pertussis toxin-sensitive G-protein in human eosinophils. Tenscher, K., Metzner, B., Hofmann, C., Schöpf, E., Norgauer, J. Biochem. Biophys. Res. Commun. (1997)
- Monocyte chemoattractant protein-4 core promoter genetic variants: influence on YY-1 affinity and plasma levels. Kalayci, O., Birben, E., Wu, L., Oguma, T., Storm Van's Gravesande, K., Subramaniam, V., Sheldon, H.K., Silverman, E.S., Lilly, C.M. Am. J. Respir. Cell Mol. Biol. (2003)
- Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines. Lamkhioued, B., Garcia-Zepeda, E.A., Abi-Younes, S., Nakamura, H., Jedrzkiewicz, S., Wagner, L., Renzi, P.M., Allakhverdi, Z., Lilly, C., Hamid, Q., Luster, A.D. Am. J. Respir. Crit. Care Med. (2000)
- Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines. Gounni Abdelilah, S., Wellemans, V., Agouli, M., Guenounou, M., Hamid, Q., Beck, L.A., Lamkhioued, B. Clin. Immunol. (2006)
- Monocyte chemoattractant protein-4 (MCP-4)/CCL13 is highly expressed in cartilage from patients with rheumatoid arthritis. Iwamoto, T., Okamoto, H., Iikuni, N., Takeuchi, M., Toyama, Y., Tomatsu, T., Kamatani, N., Momohara, S. Rheumatology (Oxford, England) (2006)
- Induction of CCL13 expression in synovial fibroblasts highlights a significant role of oncostatin M in rheumatoid arthritis. Hintzen, C., Quaiser, S., Pap, T., Heinrich, P.C., Hermanns, H.M. Arthritis Rheum. (2009)
- Differential regulation of epithelial-derived C-C chemokine expression by IL-4 and the glucocorticoid budesonide. Stellato, C., Matsukura, S., Fal, A., White, J., Beck, L.A., Proud, D., Schleimer, R.P. J. Immunol. (1999)
- C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES). Ying, S., Robinson, D.S., Meng, Q., Barata, L.T., McEuen, A.R., Buckley, M.G., Walls, A.F., Askenase, P.W., Kay, A.B. J. Immunol. (1999)
- Increased expression of the chemoattractant cytokines eotaxin, monocyte chemotactic protein-4, and interleukin-16 in induced sputum in asthmatic patients. Taha, R.A., Laberge, S., Hamid, Q., Olivenstein, R. Chest (2001)
- Chemokines and CD40 expression in human fibroblasts. Brouty-Boyé, D., Pottin-Clémenceau, C., Doucet, C., Jasmin, C., Azzarone, B. Eur. J. Immunol. (2000)
- Elevated serum monocyte chemoattractant protein-4 and chronic inflammation in overweight subjects. Hashimoto, I., Wada, J., Hida, A., Baba, M., Miyatake, N., Eguchi, J., Shikata, K., Makino, H. Obesity (Silver Spring, Md.) (2006)
- Non-steroid receptor-mediated antiproliferative activity of styrylpyrone derivative in human breast cancer cell lines. Pihie, A.H., Stanslas, J., Din, L.B. Anticancer Res. (1998)