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Gene Review

TPST1  -  tyrosylprotein sulfotransferase 1

Homo sapiens

Synonyms: Protein-tyrosine sulfotransferase 1, TANGO13A, TPST-1, Tyrosylprotein sulfotransferase 1
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Disease relevance of TPST1


Psychiatry related information on TPST1


High impact information on TPST1


Biological context of TPST1

  • We have also identified a cDNA that encodes a TPST in the nematode Caenorhabditis elegans that maps to the right arm of chromosome III [7].
  • Fine mapping of the locus for Shwachman-Diamond syndrome at 7q11, identification of shared disease haplotypes, and exclusion of TPST1 as a candidate gene [8].
  • Patients with SDS were screened for mutations in TPST1 by sequencing of exons and intron-exon junctions [8].
  • Sustained application of arterial laminar shear stress causes downregulation of TPST1 mRNA and protein expression, while TPST2 is upregulated [9].
  • Shear stress-dependent downregulation of TPST1 involves tyrosine kinase, while upregulation of TPST2 is mediated by a protein kinase C-dependent pathway [corrected] [9].

Anatomical context of TPST1


Associations of TPST1 with chemical compounds

  • A 304-residue segment in the luminal domain of TPST-2 shows 75% amino acid identity to the corresponding segment of TPST-1, including conservation of the residues implicated in the binding of PAPS [5].
  • By alanine mutation of these asparagine residues, we could determine that the N-linked oligosaccharides do not have an influence on Golgi retention of TPST1 [12].
  • Manganese appeared to exert a stimulatory effect on the zebrafish TPST [10].
  • Additionally, the activity of TPST-2, but not TPST-1, was stimulated in the presence of Mg(2+) [13].
  • These results suggest that the sensitivity of TPST activity to be controlled by protein synthesis provides a mechanism for regulation of its activity by 2-chloroadenosine [11].

Other interactions of TPST1


Analytical, diagnostic and therapeutic context of TPST1


  1. Detection and Purification of Tyrosine-sulfated Proteins Using a Novel Anti-sulfotyrosine Monoclonal Antibody. Hoffhines, A.J., Damoc, E., Bridges, K.G., Leary, J.A., Moore, K.L. J. Biol. Chem. (2006) [Pubmed]
  2. Tyrosylprotein sulfotransferase activity is increased in human gastric mucosa of alcoholics. Sundaram, P., Slomiany, B.L., Slomiany, A., Rajiyah, G., Khan, M.Y., Kasinathan, C. Am. J. Gastroenterol. (1992) [Pubmed]
  3. Tyrosine sulfation and the secretory pathway. Huttner, W.B. Annu. Rev. Physiol. (1988) [Pubmed]
  4. Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence. Seibert, C., Cadene, M., Sanfiz, A., Chait, B.T., Sakmar, T.P. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  5. Existence of distinct tyrosylprotein sulfotransferase genes: molecular characterization of tyrosylprotein sulfotransferase-2. Beisswanger, R., Corbeil, D., Vannier, C., Thiele, C., Dohrmann, U., Kellner, R., Ashman, K., Niehrs, C., Huttner, W.B. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  6. Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins. Ouyang, Y., Lane, W.S., Moore, K.L. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  7. Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans. Ouyang, Y.B., Moore, K.L. J. Biol. Chem. (1998) [Pubmed]
  8. Fine mapping of the locus for Shwachman-Diamond syndrome at 7q11, identification of shared disease haplotypes, and exclusion of TPST1 as a candidate gene. Popovic, M., Goobie, S., Morrison, J., Ellis, L., Ehtesham, N., Richards, N., Boocock, G., Durie, P.R., Rommens, J.M. Eur. J. Hum. Genet. (2002) [Pubmed]
  9. Shear stress mediates tyrosylprotein sulfotransferase isoform shift in human endothelial cells. Goettsch, S., Goettsch, W., Morawietz, H., Bayer, P. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  10. Zebrafish tyrosylprotein sulfotransferase: molecular cloning, expression, and functional characterization. Mishiro, E., Liu, M.Y., Sakakibara, Y., Suiko, M., Liu, M.C. Biochem. Cell Biol. (2004) [Pubmed]
  11. 2-Chloroadenosine decreases tyrosylprotein sulfotransferase activity in the Golgi apparatus in PC12 cells. Evidence for a novel receptor. Lin, W.H., Marcucci, K.A., Rabin, R.A., Roth, J.A. J. Biol. Chem. (1991) [Pubmed]
  12. Human TPST1 transmembrane domain triggers enzyme dimerisation and localisation to the Golgi compartment. Goettsch, S., Badea, R.A., Mueller, J.W., Wotzlaw, C., Schoelermann, B., Schulz, L., Rabiller, M., Bayer, P., Hartmann-Fatu, C. J. Mol. Biol. (2006) [Pubmed]
  13. Differential Enzymatic Characteristics and Tissue-Specific Expression of Human TPST-1 and TPST-2. Mishiro, E., Sakakibara, Y., Liu, M.C., Suiko, M. J. Biochem. (2006) [Pubmed]
  14. Tyrosine sulfation of statherin. Kasinathan, C., Gandhi, N., Ramaprasad, P., Sundaram, P., Ramasubbu, N. Int. J. Biol. Sci. (2007) [Pubmed]
  15. Characterization of a tyrosylprotein sulfotransferase in human liver. Lin, W.H., Roth, J.A. Biochem. Pharmacol. (1990) [Pubmed]
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