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Chemical Compound Review:

His-ala (2S)-2-[[(2S)-2-amino-3-(3H- imidazol-4...

Synonyms: L-His-L-Ala, AG-E-18029, SureCN5077779, CHEBI:73924, AK-60141, ...

Linetsky, M. et al., Marsh, M.E., Kanayama, T. et al., Fujimoto, D. et al., Kuboki, Y. et al., et al.

Linetsky, Hill, LeGrand, Hu,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Histidinylalanine

Unlike histidinoalanine, this crosslink appears to accumulate in relatively high concentrations in water-soluble lens proteins; its concentration was 9-fold higher than histidinoalanine from the same proteins (0.26+/-0.06 HAL vs 2.34+/-0.76 LAN nmol/mg protein; p<0.0004) [1].
Recently a cross-linking amino acid, histidinoalanine, was discovered in connective tissue and is thought to cause hardening of the tissue with aging [2].
Presence of lysinoalanine and histidinoalanine in bovine dentin phosphoprotein [3].
Age variation in histidinoalanine cross-links in proteoglycan subunits from human articular cartilage [4].
Elevation of histidinoalanine in calcified human aortas [5].

Analytical, diagnostic and therapeutic context of Histidinylalanine

The high molecular weight subunits are rich in histidinoalanine and too large to be resolved by either molecular sieve chromatography or gel electrophoresis [6].

References

Dehydroalanine crosslinks in human lens. Linetsky, M., Hill, J.M., LeGrand, R.D., Hu, F. Exp. Eye Res. (2004) [Pubmed]
Detection of the cross-linking amino acid, histidinoalanine, in human brown cataractous lens protein. Kanayama, T., Miyanaga, Y., Horiuchi, K., Fujimoto, D. Exp. Eye Res. (1987) [Pubmed]
Presence of lysinoalanine and histidinoalanine in bovine dentin phosphoprotein. Kuboki, Y., Fujisawa, R., Tsuzaki, M., Liu, C.F., Sasaki, S. Calcif. Tissue Int. (1984) [Pubmed]
Age variation in histidinoalanine cross-links in proteoglycan subunits from human articular cartilage. Fujimoto, D., Roughley, P.J. Coll. Relat. Res. (1984) [Pubmed]
Elevation of histidinoalanine in calcified human aortas. Fujimoto, D., Yu, S.Y. Biochem. Int. (1984) [Pubmed]
Histidinoalanine, a naturally occurring cross-link derived from phosphoserine and histidine residues in mineral-binding phosphoproteins. Marsh, M.E. Biochemistry (1986) [Pubmed]

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