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Chemical Compound Review

Lysinoalanine     (2S)-2-amino-6-[(2-amino-2- carboxy...

Synonyms: CCRIS 5632, LS-88423, AC1L1H3G, 4418-81-9, 18810-04-3, ...
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Disease relevance of Lysinoalanine


High impact information on Lysinoalanine


Biological context of Lysinoalanine


Anatomical context of Lysinoalanine

  • Amino acid analysis by four different systems revealed that the lysinoalanine and histidinoalanine, which had been previously reported to occur in the human dentin collagen, were concentrated in the phosphoprotein fraction but were not present in the collagen fraction [11].

Associations of Lysinoalanine with other chemical compounds

  • Formation of lysinoalanine was essentially prevented when isolates of soy protein and casein were exposed to alkali in the presence of thio-alamino acids such as cysteine [12].
  • In due course, a selective fortification of different marker compounds for lysine damage in casein-sugar mixtures was performed to provide model systems being applicable to investigate biological effects of the cross-link lysinoalanine (LAL), the MRPs fructoselysine (FL) and N epsilon-carboxymethyllysine (CML) in a casein-linked preparation [13].

Gene context of Lysinoalanine

  • D-amino acids and LAL formed during alkaline/heat treatment of proteins such as casein, lactalbumin, soy protein isolate, or wheat proteins are poorly digestible (less than 40%), and their presence can reduce protein digestibility by up to 28% in rats and pigs [14].

Analytical, diagnostic and therapeutic context of Lysinoalanine


  1. Lysinoalanine as a metal chelator. An implication for toxicity. Hayashi, R. J. Biol. Chem. (1982) [Pubmed]
  2. Lysinoalanine: absence of mutagenic response in the Salmonella/mammalian-microsome mutagenicity assay. Pintauro, S.J., Philippossian, G., Finot, P.A., Lee, T.C. Food Chem. Toxicol. (1985) [Pubmed]
  3. Lysinoalanine utilization by Erwinia chrysanthemi and Escherichia coli. Karayiannis, N.I., Panopoulos, N.J., Bjeldanes, L.F., Macgregor, J.T. Food and cosmetics toxicology. (1979) [Pubmed]
  4. Inhibition of beta-lactamases by monocyclic acyl phosph(on)ates. Kaur, K., Adediran, S.A., Lan, M.J., Pratt, R.F. Biochemistry (2003) [Pubmed]
  5. Excretion and tissue distribution of radioactive lysinoalanine, N epsilon-DL-(2-amino-2-carboxyethyl)-U-14C-L-lysine (LAL) in Sprague-Dawley rats. Struthers, B.J., Brielmaier, J.R., Raymond, M.L., Dahlgren, R.R., Hopkins, D.T. J. Nutr. (1980) [Pubmed]
  6. Effect of protein-bound lysinoalanine, N epsilon-DL-(2-amino-2-carboxyethyl)-L-lysine on fetal and neonatal rats. Struthers, B.J., Hopkins, D.T., Prescher, E.E., Dahlgren, R.R. J. Nutr. (1978) [Pubmed]
  7. Implications of antinutritional components in soybean foods. Liener, I.E. Critical reviews in food science and nutrition. (1994) [Pubmed]
  8. A procedure for the separation and quantitation of tryptophan and amino sugars on the amino acid analyzer. Johnson, D.A. Anal. Biochem. (1983) [Pubmed]
  9. Chemistry, biochemistry, nutrition, and microbiology of lysinoalanine, lanthionine, and histidinoalanine in food and other proteins. Friedman, M. J. Agric. Food Chem. (1999) [Pubmed]
  10. Influence of feeding alkaline/heat processed proteins on growth and protein and mineral status of rats. Sarwar, G., L'Abbé, M.R., Trick, K., Botting, H.G., Ma, C.Y. Adv. Exp. Med. Biol. (1999) [Pubmed]
  11. Presence of lysinoalanine and histidinoalanine in bovine dentin phosphoprotein. Kuboki, Y., Fujisawa, R., Tsuzaki, M., Liu, C.F., Sasaki, S. Calcif. Tissue Int. (1984) [Pubmed]
  12. Inhibitory effect of mercaptoamino acids on lysino-alanine formation during alkali treatment of proteins. Finley, J.W., Snow, J.T., Johnston, P.H., Friedman, M. Adv. Exp. Med. Biol. (1977) [Pubmed]
  13. Selective fortification of lysinoalanine, fructoselysine and N epsilon-carboxymethyllysine in casein model systems. Faist, V., Müller, C., Drusch, S., Erbersdobler, H.F. Die Nahrung. (2001) [Pubmed]
  14. Effects of antinutritional factors on protein digestibility and amino acid availability in foods. Gilani, G.S., Cockell, K.A., Sepehr, E. Journal of AOAC International. (2005) [Pubmed]
  15. Lysinoalanine content of formulas for enteral nutrition. Boschin, G., D'Agostina, A., Rinaldi, A., Arnoldi, A. J. Dairy Sci. (2003) [Pubmed]
  16. Lysinoalanine formation in wool after treatments with some phosphate salts. Touloupis, C., Vassiliadis, A. Adv. Exp. Med. Biol. (1977) [Pubmed]
  17. Gas-liquid chromatography and mass spectrometry of lanthionine, lysinoalanine, and S-carboxyethylcysteine. Sakamoto, M., Nakayama, F., Kajiyama, K.I. Adv. Exp. Med. Biol. (1977) [Pubmed]
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