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Chemical Compound Review

AG-C-25647     phosphonooxyphosphonic acid

Synonyms: AG-E-73870, CHEMBL1160571, CHEBI:29888, ANW-56414, CCG-37688, ...
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Disease relevance of phosphonooxyphosphonic acid

  • In the presence of PRPP, Escherichia coli and rat PRPP synthetases catalysed the pyrophosphorylation of ddAMP with efficiencies of 52 and 35% of that determined for AMP, respectively [1].

High impact information on phosphonooxyphosphonic acid

  • We conclude that the proline in the PRPP binding site of UPRTase is of only little importance for binding of PRPP to the free enzyme, but is critical for binding of uracil to the enzyme-PRPP complex and for the catalytic rate [2].
  • These enzymes and the PRPP synthases resemble each other in a short homologous sequence of 13 amino acid residues which has been termed the PRPP binding site and which interacts with the ribose 5-phosphate moiety in structurally characterized complexes of PRPP and nucleotides [2].
  • In vivo, the usual function of PRPP synthetase is to synthesize PRPP from ribose-5-phosphate and ATP [1].
  • Permanganate, with bulk quantity of alkali, alkaline earth metals, iron and aluminum, was eliminated by pyrophosphoric acid-ammonium acetate buffer solution (pH 5.5), while retaining heavy and transition metals on a selective chelating resin (MetPac CC-1 column) [3].
  • The gelation time is primarily controlled by the concentration of Na4P2O7 in solution acting as a retarder, while the level and particle size of the alginate and CaSO4 X 2H2O also affect the kinetics through the dissolution rates and concentration effects [4].

Chemical compound and disease context of phosphonooxyphosphonic acid

  • The enzyme has a low affinity for its substrates (Km = 70.5 and 186 microM for uracil and PRPP, respectively) as compared with those of E. coli and baker's yeast [5].

Biological context of phosphonooxyphosphonic acid

  • Ab initio quantum mechanical calculations were used to study the hydrolysis reaction H4P2O7 + H2O in equilibrium with 2H3PO4, as well as some molecular properties of the reactants and products [6].

Analytical, diagnostic and therapeutic context of phosphonooxyphosphonic acid


  1. Enzymatic phosphorylation and pyrophosphorylation of 2',3'-dideoxyadenosine-5'-monophosphate, a key metabolite in the pathway for activation of the anti-HIV (human immunodeficiency virus) agent 2',3'-dideoxyinosine. Navé, J.F., Eschbach, A., Wolff-Kugel, D., Halazy, S., Balzarini, J. Biochem. Pharmacol. (1994) [Pubmed]
  2. Kinetic mechanism of uracil phosphoribosyltransferase from Escherichia coli and catalytic importance of the conserved proline in the PRPP binding site. Lundegaard, C., Jensen, K.F. Biochemistry (1999) [Pubmed]
  3. On-line pretreatment and determination of Pb, Cu and Cd at the microgram l-1 level in drinking water by chelation ion chromatography. Lu, H., Mou, S., Yan, Y., Tong, S., Riviello, J.M. Journal of chromatography. A. (1998) [Pubmed]
  4. Alginate dental impression materials: chemistry, structure, and properties. Cook, W. J. Biomed. Mater. Res. (1986) [Pubmed]
  5. Characterisation of a partially purified uracil phosphoribosyltransferase from the opportunistic pathogen Candida albicans. Alloush, H.M., Kerridge, D. Mycopathologia (1994) [Pubmed]
  6. Ab initio calculations of the pyrophosphate hydrolysis reaction. Saint-Martin, H., Ortega-Blake, I., Leś, A., Adamowicz, L. Biochim. Biophys. Acta (1991) [Pubmed]
  7. Simple and rapid bioluminescent detection of two verotoxin genes using allele-specific PCR of E. coli O157: H7. Imamura, O., Arakawa, H., Maeda, M. Luminescence : the journal of biological and chemical luminescence. (2003) [Pubmed]
  8. Separation of pig bone alkaline phosphatase activities. Leunis, J.C., Vancraeynest, T., Brauman, J. Ann. Biol. Clin. (Paris) (1977) [Pubmed]
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