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Chemical Compound Review:

Acaraben ethyl2,2-bis(4-chlorophenyl)- 2-hydroxy...

Synonyms: Benzilan, Benzilen, Kopmite, Folbex, Acar, ...

Reuber, M.D., Ravindran, M., Moudgal, C.J. et al., Wang, Y.S. et al., Flodström, S. et al.

Moudgal, Venkatapathy, Choudhury, Bruce, Lipscomb,

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Disease relevance of Chlorbenzilate

Among the five potential surrogates, chlorobenzilate with an RfD of 2 x 10(-2) mg/kg-day was chosen as a surrogate for DCBP as it had the most conservative toxicity value [1].
Carcinomas of the liver and forestomach in mice ingesting chlorobenzilate [2].
Toxic encephalopathy from chlorobenzilate poisoning: report of a case [3].

High impact information on Chlorbenzilate

The dissipation of chlorobenzilate in the soil was fitted to first-order kinetics with half-lives of 5 to 36 days under various conditions in the laboratory experiments [4].
Chlorobenzilate-induced effects on enzyme-altered foci in rat liver and intercellular communication in rat liver WB-F344 epithelial cells [5].
The maximal tolerated dose of chlorobenzilate was given by continuous oral administration, starting at the age of 7 days, to both sexes of two hybrid strains of mice-(C57BL/6 X C3HAnf)F1 and (C57BL/6 X AKR)F1 [2].

Analytical, diagnostic and therapeutic context of Chlorbenzilate

A patient who developed toxic encephalopathy after exposure to chlorobenzilate mist, with associated clinical and EEG abnormalities, is briefly reported [3].

References

Application of QSTRs in the selection of a surrogate toxicity value for a chemical of concern. Moudgal, C.J., Venkatapathy, R., Choudhury, H., Bruce, R.M., Lipscomb, J.C. Environ. Sci. Technol. (2003) [Pubmed]
Carcinomas of the liver and forestomach in mice ingesting chlorobenzilate. Reuber, M.D. Digestion (1977) [Pubmed]
Toxic encephalopathy from chlorobenzilate poisoning: report of a case. Ravindran, M. Clinical EEG (electroencephalography). (1978) [Pubmed]
Dissipation and movement of acaricide chlorobenzilate in the environment. Wang, Y.S., Chen, S.W., Yen, J.H., Chen, Y.L. Ecotoxicol. Environ. Saf. (1994) [Pubmed]
Chlorobenzilate-induced effects on enzyme-altered foci in rat liver and intercellular communication in rat liver WB-F344 epithelial cells. Flodström, S., Warngård, L., Hemming, H., Ahlborg, U.G. Cancer Lett. (1988) [Pubmed]

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