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MeSH Review

Neurotoxicity Syndromes

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Gene context of Neurotoxicity Syndromes

  • We report the 1st case of capecitabine-induced toxic encephalopathy with epilepsy-like symptoms and diffuse white matter alterations on magnetic resonance imaging [12].
  • The findings indicate that long-term exposure to CS2 involves a risk of developing toxic encephalopathy, demonstrable on both neurological and neuropsychological examination [18].
  • Subjects with toxic encephalopathy of types 2A and 2B showed markedly lower P300 amplitudes than did controls in both paradigms [19].
  • The sensitivity to an experimental toxic encephalopathy was evaluated using measures of EEG and the Buschke Memory Selective Reminding Test after the administration of scopolamine hydrobromide, 0.86 mg subcutaneously, to three healthy volunteers [20].
  • The case illustrates the possibility of chronic toxic encephalopathy among patients with previous long-term exposure to CS2 [21].


  1. Psychological test performance during experimental challenge to toluene and n-butyl acetate in cases of solvent-induced toxic encephalopathy. Osterberg, K., Orbaek, P., Karlson, B., Seger, L., Akesson, B., Bergendorf, U. Scandinavian journal of work, environment & health. (2000) [Pubmed]
  2. Asterixis and toxic encephalopathy induced by gabapentin. Sechi, G., Murgia, B., Sau, G., Peddone, L., Tirotto, A., Barrocu, M., Rosati, G. Prog. Neuropsychopharmacol. Biol. Psychiatry (2004) [Pubmed]
  3. Psychological distress and coping in women married to men with a diagnosis of solvent-induced chronic toxic encephalopathy. Abjörnsson, G., Pålsson, B., Karlson, B., Orbaek, P., Osterberg, K. Brain injury : [BI]. (2005) [Pubmed]
  4. Accelerated hypertension associated with the central nervous system toxicity of metrizamide. Rodman, M.D., White, W.B. Drug intelligence & clinical pharmacy. (1986) [Pubmed]
  5. Toxic encephalopathy related to antihistamine-barbiturate antiemetic medication. Schwartz, J.F., Patterson, J.H. Am. J. Dis. Child. (1978) [Pubmed]
  6. Neuronal loss in hippocampus in rats exposed to toluene. Korbo, L., Ladefoged, O., Lam, H.R., Ostergaard, G., West, M.J., Arlien-Søborg, P. Neurotoxicology (1996) [Pubmed]
  7. An outbreak of toxic encephalopathy caused by eating mussels contaminated with domoic acid. Perl, T.M., Bédard, L., Kosatsky, T., Hockin, J.C., Todd, E.C., Remis, R.S. N. Engl. J. Med. (1990) [Pubmed]
  8. Fludarabine phosphate (NSC 312878) infusions for the treatment of acute leukemia: phase I and neuropathological study. Spriggs, D.R., Stopa, E., Mayer, R.J., Schoene, W., Kufe, D.W. Cancer Res. (1986) [Pubmed]
  9. Acute intoxication with sodium valproate. Chadwick, D.W., Cumming, W.J., Livingstone, I., Cartlidge, N.E. Ann. Neurol. (1979) [Pubmed]
  10. Isoniazid-induced acute toxic encephalopathy. Bray, P.F. Neurology (1984) [Pubmed]
  11. Concentration-effect relationships of valproic acid. Chadwick, D.W. Clinical pharmacokinetics. (1985) [Pubmed]
  12. Toxic encephalopathy induced by capecitabine. Niemann, B., Rochlitz, C., Herrmann, R., Pless, M. Oncology (2004) [Pubmed]
  13. Toxic encephalopathy caused by topically applied diphenhydramine. Filloux, F. J. Pediatr. (1986) [Pubmed]
  14. Toxic encephalopathy due to 1,1,1-trichloroethane exposure. Liss, G.M., House, R.A., Wills, M.C. Am. J. Ind. Med. (1995) [Pubmed]
  15. Evaluation of potential neurotoxic effects of occupational exposure to (L)-lactates. Clary, J.J., Feron, V.J., van Velthuijsen, J.A. Regulatory toxicology and pharmacology : RTP. (2001) [Pubmed]
  16. Glutathione S-transferase M1 null genotype as a risk modifier for solvent-induced chronic toxic encephalopathy. Söderkvist, P., Ahmadi, A., Akerbäck, A., Axelson, O., Flodin, U. Scandinavian journal of work, environment & health. (1996) [Pubmed]
  17. Serial magnet resonance angiography in patients with vasculitis and vasculitis-like angiopathy of the central nervous system. Krasnianski, M., Schlüter, A., Neudecker, S., Spielmann, R.P., Stock, K. Eur. J. Med. Res. (2004) [Pubmed]
  18. Neurological examination, computerized tomography, cerebral blood flow and neuropsychological examination in workers with long-term exposure to carbon disulfide. Aaserud, O., Gjerstad, L., Nakstad, P., Nyberg-Hansen, R., Hommeren, O.J., Tvedt, B., Russell, D., Rootwelt, K. Toxicology (1988) [Pubmed]
  19. Solvent-induced toxic encephalopathy: electrophysiological data in relation to neuropsychological findings. Lindgren, M., Osterberg, K., Orbaek, P., Rosén, I. Journal of clinical and experimental neuropsychology : official journal of the International Neuropsychological Society. (1997) [Pubmed]
  20. Utilization of a two-channel, microprocessor-based EEG device for monitoring cognitively vulnerable patients. Katz, I.R., Sussman, N.M., Mossey, J., Muenz, L., Harner, R.N., Jethanandani, V. Journal of geriatric psychiatry and neurology. (1990) [Pubmed]
  21. Cerebellar atrophy as a delayed manifestation of chronic carbon disulfide poisoning. Fonte, R., Edallo, A., Candura, S.M. Industrial health. (2003) [Pubmed]
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