Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Methybol (5S,8R,9S,10S,13S,14S,17S)- 17-hydroxy-10...

Synonyms: Preroide, Andoron, Assimil, Mesanolon, Mestalone, ...

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High impact information on RU 143

Sex reversal in medaka treated in vitro with 17alpha-methyldihydrotestosterone during oocyte maturation [1].
Both lower levels of MDHT significantly inhibited the development of female gonads as of 30dph [2].
Fish exposed to MDHT at 0.32 and 1.0mugl(-1) showed higher incidences of mixed sex gonads (10-25%) and smaller testes or dysplasia of gonadal tissue [2].
Adult Xenopus laevis were exposed in vivo to ethinylestradiol, tamoxifen, methyldihydrotestosterone and flutamide as (anti)estrogenic and (anti)androgenic compounds, respectively, for four weeks at a concentration of 10(-8) M and to Lambro river water, a polluted river from Italy [3].

Anatomical context of RU 143

Intrafollicular immature oocytes isolated before breakdown of the germinal vesicle were incubated in the presence of 17alpha-methyldihydrotestosterone (MDHT) for about 10 h during their maturational period [1].
The MDHT induced activation of Sertoli cells in the testis and a decreased presence of vitellogenic oocytes and a reduced growth of previtellogenic oocytes in the ovary [4].

References

Sex reversal in medaka treated in vitro with 17alpha-methyldihydrotestosterone during oocyte maturation. Iwamatsu, T., Kobayashi, H., Yamashita, M. Dev. Growth Differ. (2006) [Pubmed]
Development of chronic tests for endocrine active chemicals Part 2: An extended fish early-life stage test with an androgenic chemical in the fathead minnow (Pimephales promelas). Bogers, R., De Vries-Buitenweg, S., Van Gils, M., Baltussen, E., Hargreaves, A., van de Waart, B., De Roode, D., Legler, J., Murk, A. Aquat. Toxicol. (2006) [Pubmed]
Endocrine disrupters with (anti)estrogenic and (anti)androgenic modes of action affecting reproductive biology of Xenopus laevis: I. Effects on sex steroid levels and biomarker expression. Urbatzka, R., Bottero, S., Mandich, A., Lutz, I., Kloas, W. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2007) [Pubmed]
Histopathology as a tool for the evaluation of endocrine disruption in zebrafish (Danio rerio). van der Ven, L.T., Wester, P.W., Vos, J.G. Environ. Toxicol. Chem. (2003) [Pubmed]

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