Chemical Compound Review:
Drogenil 2-methyl-N-[4-nitro-3- (trifluoromethyl)phe...
Synonyms:
Eulexine, FlutaGRY, Flutamin, Flutexin, Prostica, ...
Raghow,
Kuliyev,
Steakley,
Greenberg,
Steiner,
Butcher,
Tetlow,
Cheung,
Broadhurst,
Minchin,
Wallen,
Fosså,
Slee,
Brausi,
Horenblas,
Hall,
Hetherington,
Aaronson,
de Prijck L,
Collette,
Hara,
Miyazaki,
Araki,
Yamaoka,
Kanzaki,
Kusaka,
Miyamoto,
Dawson,
Figg,
Cooper,
Sartor,
Bergan,
Senderowicz,
Steinberg,
Tompkins,
Weinberger,
Sausville,
Reed,
Myers,
Altemus,
Greenberg,
Keuler,
Jacobson,
Murphy,
- Bilateral orchiectomy with or without flutamide for metastatic prostate cancer. Eisenberger, M.A., Blumenstein, B.A., Crawford, E.D., Miller, G., McLeod, D.G., Loehrer, P.J., Wilding, G., Sears, K., Culkin, D.J., Thompson, I.M., Bueschen, A.J., Lowe, B.A. N. Engl. J. Med. (1998)
- Treatment of prostate cancer with gonadotropin-releasing hormone agonists. Labrie, F., Dupont, A., Bélanger, A., St-Arnaud, R., Giguère, M., Lacourcière, Y., Emond, J., Monfette, G. Endocr. Rev. (1986)
- Fulminant liver failure associated with flutamide therapy for hirsutism. Andrade, R.J., Lucena, M.I., Fernández, M.C., Suárez, F., Montero, J.L., Fraga, E., Hidalgo, F. Lancet (1999)
- Fatal and nonfatal hepatotoxicity associated with flutamide. Wysowski, D.K., Freiman, J.P., Tourtelot, J.B., Horton, M.L. Ann. Intern. Med. (1993)
- Efficacious chemoprevention of primary prostate cancer by flutamide in an autochthonous transgenic model. Raghow, S., Kuliyev, E., Steakley, M., Greenberg, N., Steiner, M.S. Cancer Res. (2000)
- Open trial of flutamide for treatment of obsessive-compulsive disorder. Altemus, M., Greenberg, B.D., Keuler, D., Jacobson, K.R., Murphy, D.L. The Journal of clinical psychiatry. (1999)
- Steroid hormones and Tourette's syndrome: early experience with antiandrogen therapy. Peterson, B.S., Leckman, J.F., Scahill, L., Naftolin, F., Keefe, D., Charest, N.J., King, R.A., Hardin, M.T., Cohen, D.J. Journal of clinical psychopharmacology. (1994)
- Testosterone, antiandrogen, and alloparental behavior in bobwhite quail foster fathers. Vleck, C.M., Dobrott, S.J. Hormones and behavior. (1993)
- Flutamide administration at 500 mg daily has similar effects on serum testosterone to 750 mg daily. Murphy, J.C., Srinivas, S., Terris, M.K. J. Androl. (2004)
- A controlled trial of leuprolide with and without flutamide in prostatic carcinoma. Crawford, E.D., Eisenberger, M.A., McLeod, D.G., Spaulding, J.T., Benson, R., Dorr, F.A., Blumenstein, B.A., Davis, M.A., Goodman, P.J. N. Engl. J. Med. (1989)
- Hormonal influences on sexually differentiated behavior in nonhuman primates. Wallen, K. Frontiers in neuroendocrinology. (2005)
- Surprising activity of flutamide withdrawal, when combined with aminoglutethimide, in treatment of "hormone-refractory" prostate cancer. Sartor, O., Cooper, M., Weinberger, M., Headlee, D., Thibault, A., Tompkins, A., Steinberg, S., Figg, W.D., Linehan, W.M., Myers, C.E. J. Natl. Cancer Inst. (1994)
- Bicalutamide monotherapy versus flutamide plus goserelin in prostate cancer patients: results of an Italian Prostate Cancer Project study. Boccardo, F., Rubagotti, A., Barichello, M., Battaglia, M., Carmignani, G., Comeri, G., Conti, G., Cruciani, G., Dammino, S., Delliponti, U., Ditonno, P., Ferraris, V., Lilliu, S., Montefiore, F., Portoghese, F., Spano, G. J. Clin. Oncol. (1999)
- Phase II trial of suramin, leuprolide, and flutamide in previously untreated metastatic prostate cancer. Dawson, N.A., Figg, W.D., Cooper, M.R., Sartor, O., Bergan, R.C., Senderowicz, A.M., Steinberg, S.M., Tompkins, A., Weinberger, B., Sausville, E.A., Reed, E., Myers, C.E. J. Clin. Oncol. (1997)
- Flutamide versus prednisone in patients with prostate cancer symptomatically progressing after androgen-ablative therapy: a phase III study of the European organization for research and treatment of cancer genitourinary group. Fosså, S.D., Slee, P.H., Brausi, M., Horenblas, S., Hall, R.R., Hetherington, J.W., Aaronson, N., de Prijck L, n.u.l.l., Collette, L. J. Clin. Oncol. (2001)
- Androgen-dependent apoptosis in male germ cells is regulated through the proto-oncoprotein Cbl. El Chami, N., Ikhlef, F., Kaszas, K., Yakoub, S., Tabone, E., Siddeek, B., Cunha, S., Beaudoin, C., Morel, L., Benahmed, M., Régnier, D.C. J. Cell Biol. (2005)
- The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis. Zhang, F.P., Pakarainen, T., Poutanen, M., Toppari, J., Huhtaniemi, I. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Simulation of the initial stage of endochondral ossification: in vitro sequential culture of growth cartilage cells and bone marrow cells. Suzuki, F., Takase, T., Takigawa, M., Uchida, A., Shimomura, Y. Proc. Natl. Acad. Sci. U.S.A. (1981)
- Induction of human arylamine N-acetyltransferase type I by androgens in human prostate cancer cells. Butcher, N.J., Tetlow, N.L., Cheung, C., Broadhurst, G.M., Minchin, R.F. Cancer Res. (2007)
- Flutamide Attenuates Pro-inflammatory Cytokine Production and Hepatic Injury Following Trauma-Hemorrhage via Estrogen Receptor-related Pathway. Shimizu, T., Yu, H.P., Hsieh, Y.C., Choudhry, M.A., Suzuki, T., Bland, K.I., Chaudry, I.H. Ann. Surg. (2007)
- Synthesis of cartilage matrix by mammalian chondrocytes in vitro. I. Isolation, culture characteristics, and morphology. Kuettner, K.E., Pauli, B.U., Gall, G., Memoli, V.A., Schenk, R.K. J. Cell Biol. (1982)
- Thyroid hormone, insulin, and glucocorticoids are sufficient to support chondrocyte differentiation to hypertrophy: a serum-free analysis. Quarto, R., Campanile, G., Cancedda, R., Dozin, B. J. Cell Biol. (1992)
- Basal lamina formation on thyroid epithelia in separated follicles in suspension culture. Garbi, C., Wollman, S.H. J. Cell Biol. (1982)
- Cloned endothelial cells from fetal bovine bone. Streeten, E.A., Ornberg, R., Curcio, F., Sakaguchi, K., Marx, S., Aurbach, G.D., Brandi, M.L. Proc. Natl. Acad. Sci. U.S.A. (1989)
- Androgen control of cytosol progesterone receptor levels in the MT-W9B transplantable mammary tumor in the rat. Ip, M.M., Milholland, R.J., Kim, U., Rosen, F. J. Natl. Cancer Inst. (1982)
- Cell culture of rat gastric fundic mucosa. Terano, A., Ivey, K.J., Stachura, J., Sekhon, S., Hosojima, H., McKenzie, W.N., Krause, W.J., Wyche, J.H. Gastroenterology (1982)
- Neuroblastoma cells produce transforming growth factors during exponential growth in a defined hormone-free medium. van Zoelen, E.J., Twardzik, D.R., van Oostwaard, T.M., van der Saag, P.T., de Laat, S.W., Todaro, G.J. Proc. Natl. Acad. Sci. U.S.A. (1984)
- Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist. Taplin, M.E., Bubley, G.J., Ko, Y.J., Small, E.J., Upton, M., Rajeshkumar, B., Balk, S.P. Cancer Res. (1999)
- Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome. Hara, T., Miyazaki, J., Araki, H., Yamaoka, M., Kanzaki, N., Kusaka, M., Miyamoto, M. Cancer Res. (2003)
- Effect of the multidrug resistance protein on the transport of the antiandrogen flutamide. Grzywacz, M.J., Yang, J.M., Hait, W.N. Cancer Res. (2003)
- Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells. Masiello, D., Chen, S.Y., Xu, Y., Verhoeven, M.C., Choi, E., Hollenberg, A.N., Balk, S.P. Mol. Endocrinol. (2004)
- Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3'-kinase/protein kinase B in prostate cancer cells. Mabjeesh, N.J., Willard, M.T., Frederickson, C.E., Zhong, H., Simons, J.W. Clin. Cancer Res. (2003)
- Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1. Yu, H.P., Choudhry, M.A., Shimizu, T., Hsieh, Y.C., Schwacha, M.G., Yang, S., Chaudry, I.H. J. Leukoc. Biol. (2006)
- Quality of life in advanced prostate cancer: results of a randomized therapeutic trial. Moinpour, C.M., Savage, M.J., Troxel, A., Lovato, L.C., Eisenberger, M., Veith, R.W., Higgins, B., Skeel, R., Yee, M., Blumenstein, B.A., Crawford, E.D., Meyskens, F.L. J. Natl. Cancer Inst. (1998)
- Double-blind, randomized study of primary hormonal treatment of stage D2 prostate carcinoma: flutamide versus diethylstilbestrol. Chang, A., Yeap, B., Davis, T., Blum, R., Hahn, R., Khanna, O., Fisher, H., Rosenthal, J., Witte, R., Schinella, R., Trump, D. J. Clin. Oncol. (1996)