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Chemical Compound Review

CCRIS 2527     1-[(3R,4S,5R)-3,4-dihydroxy- 5...

Synonyms: SureCN2143840, AR-1G2576, LS-160837, AC1L32HA, AC1Q6C4M, ...
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Disease relevance of CCRIS 2527


High impact information on CCRIS 2527


Chemical compound and disease context of CCRIS 2527

  • The mechanism of this reversion is considered to consist of metabolic conversion of N4-aminocytidine into its deoxynucleoside 5'-triphosphate followed by incorporation of the nucleotide into the replicating phage DNA, thereby causing AT-to-GC transition at the am3 locus [7].
  • N4-Aminodeoxycytidine triphosphate, a putative metabolite of N4-aminocytidine which is a potent mutagen, is incorporated, in vitro, into polynucleotides in place of dCTP and at a much lesser extent, but significantly, in place of dTTP by E. coli DNA polymerase I large fragment [8].


  1. N4-aminocytidine, a nucleoside analog that has an exceptionally high mutagenic activity. Negishi, K., Harada, C., Ohara, Y., Oohara, K., Nitta, N., Hayatsu, H. Nucleic Acids Res. (1983) [Pubmed]
  2. Spectrum of N4-aminocytidine mutagenesis. Bessho, T., Matsumoto, K., Nomura, A., Hayatsu, H., Negishi, K. J. Mol. Biol. (1989) [Pubmed]
  3. Mutagenic nucleoside analog N4-aminocytidine: metabolism, incorporation into DNA, and mutagenesis in Escherichia coli. Negishi, K., Tamanoi, K., Ishii, M., Kawakami, M., Yamashita, Y., Hayatsu, H. J. Bacteriol. (1988) [Pubmed]
  4. Induction of mutation in mouse FM3A cells by N4-aminocytidine-mediated replicational errors. Takahashi, M., Nishizawa, M., Negishi, K., Hanaoka, F., Yamada, M.A., Hayatsu, H. Mol. Cell. Biol. (1988) [Pubmed]
  5. Direct-acting mutagenicity of N4-aminocytidine derivatives bearing alkyl groups at the hydrazino nitrogens. Nomura, A., Negishi, K., Hayatsu, H. Nucleic Acids Res. (1985) [Pubmed]
  6. Effect of Escherichia coli dnaE antimutator mutants on mutagenesis by the base analog N4-aminocytidine. Schaaper, R.M., Dunn, R.L. Mutat. Res. (1998) [Pubmed]
  7. Induction of mutation in vitro in phage phi X174 am3 by N4-aminodeoxycytidine triphosphate. Takahashi, M., Negishi, K., Hayatsu, H. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
  8. Proofreading of a mutagenic nucleotide, N4-aminodeoxycytidylic acid, by Escherichia coli DNA polymerase I. Takahashi, M., Negishi, K., Hayatsu, H. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
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