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Gene Review

Oua1  -  ouabain resistance 1

Mus musculus

Synonyms: Oua-1
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Disease relevance of Oua1


High impact information on Oua1


Chemical compound and disease context of Oua1


Biological context of Oua1


Anatomical context of Oua1


Associations of Oua1 with chemical compounds


Other interactions of Oua1


Analytical, diagnostic and therapeutic context of Oua1


  1. Induction of cytotoxicity, mutation, cytogenetic changes, and neoplastic transformation by benzo(a)pyrene and derivatives in C3H/10T1/2 clone 8 mouse fibroblasts. Gehly, E.B., Landolph, J.R., Heidelberger, C., Nagasawa, H., Little, J.B. Cancer Res. (1982) [Pubmed]
  2. The tumour promoter TPA does not affect mutation to ouabain resistance in L5178Y mouse lymphoma cells. Lasne, C., Cole, J., Arlett, C.F. Carcinogenesis (1980) [Pubmed]
  3. Aphidicolin-resistant mutator strains of mouse teratocarcinoma. Aizawa, S., Loeb, L.A., Martin, G.M. Mol. Gen. Genet. (1987) [Pubmed]
  4. Relationship between O6-alkylguanine-DNA alkyltransferase activity and N-methyl-N'-nitro-N-nitrosoguanidine-induced mutation, transformation, and cytotoxicity in C3H/10T1/2 cells expressing exogenous alkyltransferase genes. von Hofe, E., Fairbairn, L., Margison, G.P. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  5. Molecular cloning of the mouse ouabain-resistance gene. Levenson, R., Racaniello, V., Albritton, L., Housman, D. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  6. Differential cell cycle phase specificity for neoplastic transformation and mutation to ouabain resistance induced by N-methyl-N'-nitro-N-nitrosoguanidine in synchronized C3H10T 1/2 C18 cells. McCormick, P.J., Bertram, J.S. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  7. A comparison of the agar cloning and microtitration techniques for assaying cell survival and mutation frequency in L5178Y mouse lymphoma cells. Cole, J., Arlett, C.F., Green, M.H., Lowe, J., Muriel, W. Mutat. Res. (1983) [Pubmed]
  8. Ouabain-resistant transfectants of the murine ouabain resistance gene contain mutations in the alpha-subunit of the Na,K-ATPase. Cantley, L.G., Zhou, X.M., Cunha, M.J., Epstein, J., Cantley, L.C. J. Biol. Chem. (1992) [Pubmed]
  9. A murine genomic DNA fragment amplifies ouabain-induced Na,K-ATPase alpha/beta-subunit mRNA up-regulation and confers ouabain resistance. Zhou, X.M., Cunha, M.J., Epstein, J., Levenson, R., Cantley, L.C., Cantley, L.G. J. Biol. Chem. (1993) [Pubmed]
  10. Assignment of the gene governing cellular ouabain resistance to Mus musculus chromosome 3 using human/mouse microcell hybrids. Kozak, C.A., Fournier, R.E., Leinwand, L.A., Ruddle, F.H. Biochem. Genet. (1979) [Pubmed]
  11. Chemical carcinogens produce mutations to ouabain resistance in transformable C3H/10T1/2 Cl 8 mouse fibroblasts. Landolph, J.R., Heidelberger, C. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  12. Reduced ouabain inhibition of Na,K-activated adenosine triphosphatase in cultured cell recipients of the ouabain-resistance gene. Pressley, T.A., Edelman, I.S. J. Biol. Chem. (1986) [Pubmed]
  13. Structure-function relationships in the Na,K-ATPase alpha subunit: site-directed mutagenesis of glutamine-111 to arginine and asparagine-122 to aspartic acid generates a ouabain-resistant enzyme. Price, E.M., Lingrel, J.B. Biochemistry (1988) [Pubmed]
  14. The mutagenic response at the ouabain resistance locus in T cells of mice exposed to N-ethyl-N-nitrosourea parallels the response at the Hprt locus and correlates with mutation target size. Dass, S.B., Heflich, R.H., Casciano, D.A. Carcinogenesis (1997) [Pubmed]
  15. Increasing metastatic potential is associated with increasing genetic instability of clones isolated from murine neoplasms. Cifone, M.A., Fidler, I.J. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  16. Mutagenesis in S49 mouse lymphoma cells: induction of resistance to ouabain, 6-thioguanine, and dibutyryl cyclic AMP. Friedrich, U., Coffino, P. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  17. Induction of mutation in mouse FM3A cells by N4-aminocytidine-mediated replicational errors. Takahashi, M., Nishizawa, M., Negishi, K., Hanaoka, F., Yamada, M.A., Hayatsu, H. Mol. Cell. Biol. (1988) [Pubmed]
  18. Transformation of C3H/10T1/2 mouse embryo cells to focus formation and anchorage independence by insoluble lead chromate but not soluble calcium chromate: relationship to mutagenesis and internalization of lead chromate particles. Patierno, S.R., Banh, D., Landolph, J.R. Cancer Res. (1988) [Pubmed]
  19. International Commission for Protection against Environmental Mutagens and Carcinogens. ICPEMC working paper 2/5: mutagenesis in mammalian cells. Howard-Flanders, P. Mutat. Res. (1981) [Pubmed]
  20. Mutagenicity of 5-azacytidine and related nucleosides in C3H/10T 1/2 clone 8 and V79 cells. Landolph, J.R., Jones, P.A. Cancer Res. (1982) [Pubmed]
  21. Neurite extension and increased expression of RI cyclic AMP-binding protein in ouabain-resistant neuroblastoma mutants. Meyer, S.A., Lin, Z., Liu, A.Y. J. Neurochem. (1988) [Pubmed]
  22. The relationship between DNA damage and mutation frequency in mammalian cell lines treated with N-nitroso-N-2-fluorenylacetamide. Kuo, M.L., Lin, J.K. Mutat. Res. (1989) [Pubmed]
  23. Split-dose exposure to N-methyl-N'-nitro-N-nitrosoguanidine in BALB/3T3 C1 a31-1-1 cells: evidence of DNA repair by alkaline elution without changes in cell survival, mutation and transformation rates. Bignami, M., Dogliotti, E., Benigni, R., Kaighn, M.E., Saffiotti, U. Mutat. Res. (1985) [Pubmed]
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