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Chemical Compound Review:

Bifendate methyl 7-methoxy-4-(7-methoxy-5...

Synonyms: Bifendatatum, CHEMBL105184, SureCN896166, CCRIS 7767, AC1Q5ZQJ, ...

Zhou, L. et al., Pan, S.Y. et al., Pan, S.Y. et al., Wu, T. et al., Guan, L.P. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Bifendate

The results indicate that bifendate treatment can invariably decrease hepatic (but not serum) lipid levels in various mouse models of hypercholesterolemia [1].
High doses of bifendate elevate serum and hepatic triglyceride levels in rabbits and mice: animal models of acute hypertriglyceridemia [2].
MAIN RESULTS: The search identified one randomised clinical trial comparing bicyclol with bifendate (biphenyldicarboxylate) for patients with hepatitis B [3].

High impact information on Bifendate

Bifendate treatment attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice [1].
Determination of bifendate in human plasma by HPLC-MS and bioequivalence on bifendate pills in healthy volunteers [4].
The hypertriglyceridemia induced by bifendate was ameliorated by fenofibrate but not inositol nicotinate treatment in mice [2].

Analytical, diagnostic and therapeutic context of Bifendate

A sensitive and specific method for the determination of bifendate in human plasma was developed, based on high-performance liquid chromatography (HPLC)-mass spectrometry (MS) [4].
The activity of compound 3 was compared with the bifendate (DDB) through oral administration [5].

References

Bifendate treatment attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice. Pan, S.Y., Yang, R., Dong, H., Yu, Z.L., Ko, K.M. Eur. J. Pharmacol. (2006) [Pubmed]
High doses of bifendate elevate serum and hepatic triglyceride levels in rabbits and mice: animal models of acute hypertriglyceridemia. Pan, S.Y., Yang, R., Han, Y.F., Dong, H., Feng, X.D., Li, N., Geng, W., Ko, K.M. Acta Pharmacol. Sin. (2006) [Pubmed]
Bicyclol for chronic hepatitis B. Wu, T., Roger, H., Xie, L., Liu, G., Hao, B. Cochrane database of systematic reviews (Online) (2006) [Pubmed]
Determination of bifendate in human plasma by HPLC-MS and bioequivalence on bifendate pills in healthy volunteers. Zhou, L., Gu, L., Wang, Y., Liang, J. Journal of pharmaceutical and biomedical analysis. (2006) [Pubmed]
Protective effects of chalcone derivatives for acute liver injury in mice. Guan, L.P., Nan, J.X., Jin, X.J., Jin, Q.H., Kwak, K.C., Chai, K.Y., Quan, Z.S. Arch. Pharm. Res. (2005) [Pubmed]

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