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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Glycofural     2-(oxolan-2-ylmethoxy)ethanol

Synonyms: Glycofurol, THFP, Glycofurol 75, ARONIS24457, SureCN166926, ...
 
 
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Disease relevance of Glycofurol

 

High impact information on Glycofurol

 

Biological context of Glycofurol

  • Combining the two enhancers did not lead to increased peptide T absorption compared to 5% glycofurol alone [6].
 

Associations of Glycofurol with other chemical compounds

  • The bioavailability, measured during the first 30 min, because periods after this are not relevant for acute treatment, was found to be between 49 and 62% for the four most promising vehicles, pure glycofurol 75, tetraethyleneglycol, poly(ethylene glycol) 200 and 30% glycofurol in tetraethyleneglycol [7].
 

Analytical, diagnostic and therapeutic context of Glycofurol

  • Control animals (group 1, n = 11) received an infusion of vehicle [50% vol/vol glycofurol and distilled water, 47 ml at 12 ml h-1, intravenously (i.v.)] beginning 15 min before ischaemia and continuing until the end of reperfusion [8].

References

  1. Disposition of intravenous glycofurol: effect of hepatic cirrhosis. Bury, R.W., Breen, K.J., Desmond, P.V., Raymond, K., Mashford, M.L. Clin. Pharmacol. Ther. (1984) [Pubmed]
  2. Development and evaluation of microbicidal hydrogels containing monoglyceride as the active ingredient. Kristmundsdóttir, T., Arnadóttir, S.G., Bergsson, G., Thormar, H. Journal of pharmaceutical sciences. (1999) [Pubmed]
  3. A new injectable carbamazepine solution--antiepileptic effects and pharmaceutical properties. Taubøll, E., Lindström, S., Klem, W., Gjerstad, L. Epilepsy Res. (1990) [Pubmed]
  4. Intravenous carbamazepine: comparison of different parenteral formulations in a mouse model of convulsive status epilepticus. Löscher, W., Hönack, D. Epilepsia (1997) [Pubmed]
  5. New injectable aqueous carbamazepine solution through complexing with 2-hydroxypropyl-beta-cyclodextrin: tolerability and pharmacokinetics after intravenous injection in comparison to a glycofurol-based formulation. Löscher, W., Hönack, D., Richter, A., Schulz, H.U., Schürer, M., Düsing, R., Brewster, M.E. Epilepsia (1995) [Pubmed]
  6. Nasal bioavailability of peptide T in rabbits: absorption enhancement by sodium glycocholate and glycofurol. Bagger, M.A., Nielsen, H.W., Bechgaard, E. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (2001) [Pubmed]
  7. Pharmacokinetic and pharmacodynamic response after intranasal administration of diazepam to rabbits. Bechgaard, E., Gizurarson, S., Hjortkjaer, R.K. J. Pharm. Pharmacol. (1997) [Pubmed]
  8. Selective 5-lipoxygenase inhibitor BW A4C does not influence progression of tissue injury in a canine model of regional myocardial ischaemia and reperfusion. Maxwell, M.P., Marston, C., Hadley, M.R., Salmon, J.A., Garland, L.G. J. Cardiovasc. Pharmacol. (1991) [Pubmed]
 
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