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Chemical Compound Review

AKOS006282750     2-butan-2-yl-4-ethanoyl-5- hydroxy-1,2...

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Disease relevance of TENUAZONIC ACID

  • In conclusion, our results suggested that TeA has higher toxicity as evidenced by dysplastic transformation [1].

High impact information on TENUAZONIC ACID

  • Electron-microscopic examination of TeA-treated mucosal epithelial cells revealed pyknosis in some nuclei, granulation and increase in chromatin mass, irregularities in the nuclear contours, vacuolization in nucleoplasms. and marked pleomorphism in the nuclei [1].
  • In this study, the possible toxic effects of Alternariol Methyl Ether (AME) and Tenuazonic Acid (TeA) produced by Alternaria species on esophagus of mice were investigated by using light and electron microscopy techniques [1].
  • Mice were orally fed daily with AME or TeA for 10 months and at the end of this period, the effects of these chemicals on the esophageal mucosa were determined [1].
  • A multi-toxin method was developed for the detection of some of the known Alternaria mycotoxins, altenuene, iso-altenuene, alternariol, alternariol monomethyl ether, tenuazonic acid and altertoxin I in oilseed rape meal and sunflower seed meal [2].
  • Tenuazonic acid (TA) was topically applied to the interscapular region of Swiss albino mice at different doses before the application of 12-O-tetradecanoyl phorbol-13-acetate (TPA) [3].

Associations of TENUAZONIC ACID with other chemical compounds

  • Chaetocin, penitrem A, and xanthocillin were identified only from black pepper, and tenuazonic acid was identified from both black and white pepper [4].
  • LC separation of tenuazonic acid from interferences was best on a C12-dien (4-dodecyldiethylenetriamine) loaded C18 reverse phase column with a mobile phase containing C12-dien, Zn(II), and ammonium acetate, or on a tetraalkylammonium anion exchange column at pH 7 [5].

Gene context of TENUAZONIC ACID

  • The natural occurrence of major Alternaria mycotoxins i.e. alternariol (AOH), alternariol methyl ether (AME), altenuene (ALT), altertoxin-1 (ATX-1) and tenuazonic acid (TA) has been investigated in sorghum (Sorghum vulgare Pers.) and ragi (Eleusine coracana Gaertn.) collected from North Bihar [6].

Analytical, diagnostic and therapeutic context of TENUAZONIC ACID


  1. Analysis of toxic effects of Alternaria toxins on esophagus of mice by light and electron microscopy. Yekeler, H., Bitmiş, K., Ozçelik, N., Doymaz, M.Z., Calta, M. Toxicologic pathology. (2001) [Pubmed]
  2. Mycotoxins in ingredients of animal feeding stuffs: I. Determination of Alternaria mycotoxins in oilseed rape meal and sunflower seed meal. Nawaz, S., Scudamore, K.A., Rainbird, S.C. Food additives and contaminants. (1997) [Pubmed]
  3. Inhibition of mouse skin tumor promotion by tenuazonic acid. Antony, M., Gupta, K.P., Janardanan, K.K., Mehrotra, N.K. Cancer Lett. (1991) [Pubmed]
  4. Mycoflora and mycotoxins in Brazilian black pepper, white pepper and Brazil nuts. Freire, F.C., Kozakiewicz, Z., Paterson, R.R. Mycopathologia (2000) [Pubmed]
  5. Liquid chromatographic determination of tenuazonic acids in tomato paste. Scott, P.M., Kanhere, S.R. Journal - Association of Official Analytical Chemists. (1980) [Pubmed]
  6. Natural occurrence of Alternaria mycotoxins in sorghum and ragi from North Bihar, India. Ansari, A.A., Shrivastava, A.K. Food additives and contaminants. (1990) [Pubmed]
  7. Tenuazonic acid production by Alternaria alternata and Alternaria tenuissima isolated from cotton. Davis, N.D., Diener, U.L., Morgan-Jones, G. Appl. Environ. Microbiol. (1977) [Pubmed]
  8. Reversed-phase high-performance liquid chromatography of tenuazonic acid and related tetramic acids. Shephard, G.S., Thiel, P.G., Sydenham, E.W., Vleggaar, R., Marasas, W.F. J. Chromatogr. (1991) [Pubmed]
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