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Chemical Compound Review:

R-bisabolol (2S)-6-methyl-2-[(1R)-4- methyl-1-cyclohex...

Synonyms: CHEMBL519167, AG-F-74694, SureCN1245143, CHEBI:68658, ANW-41513, ...

Cavalieri, E. et al., Szöke, E. et al., Ganzera, M. et al., Gomes-Carneiro, M.R. et al., Verma, A.K. et al.

Ganzera, Schneider, Stuppner, Szöke, Máday, Kiss, Sonnewend, Lemberkovics,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of alpha-Bisabolol

In this study, alpha-bisabolol, a sesquiterpene alcohol present in natural essential oil, was found to have a strong time- and dose-dependent cytotoxic effect on human and rat glioma cells [1].
Evaluation of mutagenic and antimutagenic activities of alpha-bisabolol in the Salmonella/microsome assay [2].

High impact information on alpha-Bisabolol

Glioma cells treated with high concentration of alpha-bisabolol (10 microM) resulted in a 100% cell death [1].
alpha-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells [1].
Furthermore, the viability of normal rat glial cells was not affected by treatment with alpha-bisabolol at the same concentrations as above [1].
Judging from hypo-G1 accumulation, poly(ADP-ribose) polymerase cleavage, and DNA ladder formation, the cytotoxicity triggered by alpha-bisabolol resulted from apoptosis induction [1].
CYP2C9 and CYP2D6 were less inhibited, only chamazulene (IC50 = 1.06 microM) and alpha-bisabolol (IC50 = 2.18 microM) revealed a significant inhibition of the latter [3].

Biological context of alpha-Bisabolol

As pointed out by the experimental results, alpha-bisabolol may be considered a novel compound able to inhibit glioma cell growth and survival [1].

Associations of alpha-Bisabolol with other chemical compounds

OBJECTIVE: The importance of chamomile (Chamomilla recutita) is widely known in classical and folk medicine, with the largest group of its effective substances forming the essential oil (chamazulene, alpha-bisabolol, trans-beta-farnesene, spathulenol, cis/trans-en-in-dicycloethers) [4].

Analytical, diagnostic and therapeutic context of alpha-Bisabolol

A component, alpha-bisabolol, was identified using gas chromatography and UV spectroscopy [5].

References

alpha-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells. Cavalieri, E., Mariotto, S., Fabrizi, C., de Prati, A.C., Gottardo, R., Leone, S., Berra, L.V., Lauro, G.M., Ciampa, A.R., Suzuki, H. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
Evaluation of mutagenic and antimutagenic activities of alpha-bisabolol in the Salmonella/microsome assay. Gomes-Carneiro, M.R., Dias, D.M., De-Oliveira, A.C., Paumgartten, F.J. Mutat. Res. (2005) [Pubmed]
Inhibitory effects of the essential oil of chamomile (Matricaria recutita L.) and its major constituents on human cytochrome P450 enzymes. Ganzera, M., Schneider, P., Stuppner, H. Life Sci. (2006) [Pubmed]
Effect of magnesium on essential oil formation of genetically transformed and non-transformed chamomile cultures. Szöke, E., Máday, E., Kiss, S.A., Sonnewend, L., Lemberkovics, E. Journal of the American College of Nutrition. (2004) [Pubmed]
Anthocyanin, bisabolol and phenylammonialyase activity in cell cultures of Populus deltoides. Verma, A.K., Chaudhary, U., Kumar, R., Pant, A.K., Gaur, A.K., Lakhchaura, B.D. Indian J. Exp. Biol. (2000) [Pubmed]

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