Disease relevance of Su 4885

• Carbon monoxide (11.5% in the inspired gas) and metyrapone ditartrate (10 mg/min into the perfusate) caused vasodilation when oxygenation was normal and reduced the vasoconstriction caused by hypoxia [1].

High impact information on Su 4885

• In vitro conversion of 4-14C-progesterone into corticosteroids in the adrenal glands of rat fetuses treated with Metopirone (Su 4885) on the last day of intrauterine development was studied [2].
• 1. Non-shivering thermogenesis (NST) was studied in 8 hedgehogs before and after a single injection of metopirone ditartrate (150-450 mg/kg, i.p.) at a thermoneutral chamber temperature (Ta) of 28C and during cold exposure (Ta = 8 degrees C for 20 min) [3].
• The LD50 for metyrapone tartrate was 760 mg/kg i.p. Metyrapone decreased or prevented acetaminophen induced hepatic damage measured either by histology or plasma glutamate pyruvate transaminase activity [4].
• An injection of DOC (3 mg/kg, i.m.) increases NST at hermoneutrality similar to the initial metabolic effect elicited by metopirone ditartrate [3].
• An intravenous metyrapone tartrate test was performed on 26 children to assess growth hormone (GH) reserve and pituitary-adrenal axis [5].

Analytical, diagnostic and therapeutic context of Su 4885

• Metyrapone tartrate testing was used to assess the function of the hypothalamic-pituitary-adrenal (HPA) axis during, after, and, in one case, before the drug therapy [6].

References