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Chemical Compound Review

gamma-Pyridone     1H-pyridin-4-one

Synonyms: pyridin-4-ol, PubChem1116, PubChem2568, SureCN3107, ARONIS23890, ...
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Disease relevance of gamma-Pyridone


High impact information on gamma-Pyridone


Biological context of gamma-Pyridone


Associations of gamma-Pyridone with other chemical compounds

  • 2. Human liver microsomal fractions incubated with an NADPH-generating system and oxygen formed pyridine N-oxide (PNO) at an average rate of 275 pmol/min per mg protein, 2-pyridone (2PO) at 207 pmol/min per mg and 4-pyridone (4PO) at 154 pmol/min per mg [9].
  • The hypoglycemic effect of a 4-pyridone-type compound was similar to that of (-)-multiflorine as measured by oral glucose tolerance testing in normal mice [10].


  1. 4-Pyridone derivatives as new inhibitors of bacterial enoyl-ACP reductase FabI. Kitagawa, H., Kumura, K., Takahata, S., Iida, M., Atsumi, K. Bioorg. Med. Chem. (2007) [Pubmed]
  2. Studies on the activity of three palladium(II) compounds of the form: Trans-PdL(2)Cl(2) where L=2-hydroxypyridine, 3-hydroxypyridine, and 4-hydroxypyridine. Huq, F., Tayyem, H., Beale, P., Yu, J.Q. J. Inorg. Biochem. (2007) [Pubmed]
  3. Comparative induction of CYP1A1 expression by pyridine and its metabolites. Iba, M.M., Fung, J., Giannone, J.V., Okey, A.B. Arch. Biochem. Biophys. (2000) [Pubmed]
  4. Interaction of the tumor inhibitor IKP-104, a 4(1H)-pyridinone derivative, with microtubule proteins. Mizuhashi, F., Murata, K., Kitagaki, T., Tomita, I. Jpn. J. Cancer Res. (1992) [Pubmed]
  5. Piperidones with activity against Plasmodium falciparum. Saeftel, M., Sarite, R.S., Njuguna, T., Holzgrabe, U., Ulmer, D., Hoerauf, A., Kaiser, A. Parasitol. Res. (2006) [Pubmed]
  6. Development of a multivariate statistical model to predict peroxisome proliferation in the rat, based on urinary 1H-NMR spectral patterns. Connor, S.C., Hodson, M.P., Ringeissen, S., Sweatman, B.C., McGill, P.J., Waterfield, C.J., Haselden, J.N. Biomarkers (2004) [Pubmed]
  7. Effects of known and potential antioxidants on animal models of pathological processes (diabetes, gastric lesions, allergic bronchospasm). Stetinová, V., Grossmann, V. Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie. (2000) [Pubmed]
  8. New 4-hydroxypyridine and 4-hydroxyquinoline derivatives as inhibitors of NADH-ubiquinone reductase in the respiratory chain. Chung, K.H., Cho, K.Y., Asami, Y., Takahashi, N., Yoshida, S. Z. Naturforsch., C, J. Biosci. (1989) [Pubmed]
  9. Oxidative metabolism of 14C-pyridine by human and rat tissue subcellular fractions. Wilke, T.J., Jondorf, W.R., Powis, G. Xenobiotica (1989) [Pubmed]
  10. Hypoglycemic effects of multiflorine derivatives in normal mice. Kubo, H., Inoue, M., Kamei, J., Higashiyama, K. Biol. Pharm. Bull. (2006) [Pubmed]
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