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Chemical Compound Review

Batrafen     2-aminoethanol; 6-cyclohexyl-1-hydroxy-4...

Synonyms: Brumixol, Ciclochem, Micoxolamina, Prestwick_785, HOE-296, ...
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Disease relevance of Loprox


High impact information on Loprox


Chemical compound and disease context of Loprox


Biological context of Loprox


Anatomical context of Loprox

  • Inclusion of ciclopirox initially increased the MTP, maintained it high, and blocked the ATP depletion in glucose-deprived SIN-1-treated astrocytes [14].
  • With repeated applications, the antifungal agent is homogeneously distributed through all layers of the toenail achieving concentrations of ciclopirox in excess of inhibitory and fungicidal concentrations for most pathogens [19].
  • Effects of subinhibitory concentrations of ciclopirox on the adherence of Candida albicans to human buccal and vaginal epithelial cells [20].

Associations of Loprox with other chemical compounds


Gene context of Loprox


Analytical, diagnostic and therapeutic context of Loprox


  1. Ciclopirox olamine 1% cream. A preliminary review of its antimicrobial activity and therapeutic use. Jue, S.G., Dawson, G.W., Brogden, R.N. Drugs (1985) [Pubmed]
  2. Common superficial fungal infections in patients with AIDS. Aly, R., Berger, T. Clin. Infect. Dis. (1996) [Pubmed]
  3. Ciclopirox protects mitochondria from hydrogen peroxide toxicity. Lee, S.J., Jin, Y., Yoon, H.Y., Choi, B.O., Kim, H.C., Oh, Y.K., Kim, H.S., Kim, W.K. Br. J. Pharmacol. (2005) [Pubmed]
  4. Treatment and prophylaxis of seborrheic dermatitis of the scalp with antipityrosporal 1% ciclopirox shampoo. Shuster, S., Meynadier, J., Kerl, H., Nolting, S. Archives of dermatology. (2005) [Pubmed]
  5. Randomized, placebo-controlled, double-blind study on clinical efficacy of ciclopiroxolamine 1% cream in facial seborrhoeic dermatitis. Dupuy, P., Maurette, C., Amoric, J.C., Chosidow, O. Br. J. Dermatol. (2001) [Pubmed]
  6. Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support. Farinelli, S.E., Greene, L.A. J. Neurosci. (1996) [Pubmed]
  7. Homologous recombination induced by replication inhibition, is stimulated by expression of mutant p53. Saintigny, Y., Lopez, B.S. Oncogene (2002) [Pubmed]
  8. Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization. Urbani, L., Sherwood, S.W., Schimke, R.T. Exp. Cell Res. (1995) [Pubmed]
  9. Oxygen accessibility and iron levels are critical factors for the antifungal action of ciclopirox against Candida albicans. Sigle, H.C., Thewes, S., Niewerth, M., Korting, H.C., Schäfer-Korting, M., Hube, B. J. Antimicrob. Chemother. (2005) [Pubmed]
  10. Congenital candidal onychomycoses: effective cure with ciclopirox olamine 8% nail lacquer. Sardana, K., Garg, V.K., Manchanda, V., Rajpal, M. Br. J. Dermatol. (2006) [Pubmed]
  11. Anti-inflammatory and anti-itch activity of sertaconazole nitrate. Liebel, F., Lyte, P., Garay, M., Babad, J., Southall, M.D. Arch. Dermatol. Res. (2006) [Pubmed]
  12. Hendersonula toruloidea infection: successful response of onychomycosis to nail avulsion and topical ciclopiroxolamine. Rollman, O., Johansson, S. Acta Derm. Venereol. (1987) [Pubmed]
  13. Pharmacoeconomic assessment of ciclopirox topical solution, 8%, oral terbinafine, and oral itraconazole for onychomycosis. Gupta, A.K., Lynde, C.W., Barber, K. Journal of cutaneous medicine and surgery (2006) [Pubmed]
  14. Ciclopirox prevents peroxynitrite toxicity in astrocytes by maintaining their mitochondrial function: a novel mechanism for cytoprotection by ciclopirox. Choi, J.J., Kong, M.Y., Lee, S.J., Kim, H.C., Ko, K.H., Kim, W.K. Neuropharmacology (2002) [Pubmed]
  15. Eukaryotic initiation factor 5A-1 (eIF5A-1) as a diagnostic marker for aberrant proliferation in intraepithelial neoplasia of the vulva. Cracchiolo, B.M., Heller, D.S., Clement, P.M., Wolff, E.C., Park, M.H., Hanauske-Abel, H.M. Gynecol. Oncol. (2004) [Pubmed]
  16. Pharmacokinetics of ciclopirox olamine after vaginal application to rabbits and patients. Coppi, G., Silingardi, S., Girardello, R., De Aloysio, D., Manzardo, S. Journal of chemotherapy (Florence, Italy) (1993) [Pubmed]
  17. Changes in fungal ultrastructure after short-course ciclopiroxolamine therapy in pityriasis versicolor. del Palacio-Hernanz, A., Guarro-Artigas, J., Figueras-Salvat, M.J., Esteban-Moreno, J., Lopez-Gomez, S. Clin. Exp. Dermatol. (1990) [Pubmed]
  18. Evaluation of the drug treatment and persistence of onychomycosis. Campbell, A.W., Anyanwu, E.C., Morad, M. ScientificWorldJournal (2004) [Pubmed]
  19. Dermatopharmacology of ciclopirox nail lacquer topical solution 8% in the treatment of onychomycosis. Bohn, M., Kraemer, K.T. J. Am. Acad. Dermatol. (2000) [Pubmed]
  20. Effects of subinhibitory concentrations of ciclopirox on the adherence of Candida albicans to human buccal and vaginal epithelial cells. Braga, P.C., Piatti, G., Conti, E., Vignali, F. Arzneimittel-Forschung. (1992) [Pubmed]
  21. In vitro susceptibility testing of ciclopirox, terbinafine, ketoconazole and itraconazole against dermatophytes and nondermatophytes, and in vitro evaluation of combination antifungal activity. Gupta, A.K., Kohli, Y. Br. J. Dermatol. (2003) [Pubmed]
  22. Evaluation of fungicidal action in vitro and in a skin model considering the influence of penetration kinetics of various standard antimycotics. Hänel, H., Raether, W., Dittmar, W. Ann. N. Y. Acad. Sci. (1988) [Pubmed]
  23. Piperidones with activity against Plasmodium falciparum. Saeftel, M., Sarite, R.S., Njuguna, T., Holzgrabe, U., Ulmer, D., Hoerauf, A., Kaiser, A. Parasitol. Res. (2006) [Pubmed]
  24. The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis. Linden, T., Katschinski, D.M., Eckhardt, K., Scheid, A., Pagel, H., Wenger, R.H. FASEB J. (2003) [Pubmed]
  25. Ciclopirox nail lacquer topical solution 8% in the treatment of toenail onychomycosis. Gupta, A.K., Fleckman, P., Baran, R. J. Am. Acad. Dermatol. (2000) [Pubmed]
  26. Quantification of ciclopirox by high-performance liquid chromatography after pre-column derivatization. An example of efficient clean-up using silica-bonded cyano phases. Lehr, K.H., Damm, P. J. Chromatogr. (1985) [Pubmed]
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