Chemical Compound Review:
pyridone 1H-pyridin-2-one
Synonyms:
PYRIDON, alpha-Pyridone, Pyridone-2, CHEMBL662, Pyridin-2-ol, ...
Dragovich,
Prins,
Zhou,
Johnson,
Brown,
Maldonado,
Fuhrman,
Zalman,
Patick,
Matthews,
Hou,
Meador,
Ferre,
Worland,
Dragovich,
Prins,
Zhou,
Brown,
Maldonado,
Fuhrman,
Zalman,
Tuntland,
Lee,
Patick,
Matthews,
Hendrickson,
Kosa,
Liu,
Batugo,
Gleeson,
Sakata,
Chen,
Guzman,
Meador,
Ferre,
Worland,
Adam,
Hartung,
Okamoto,
Marquardt,
Nau,
Pischel,
Saha-Möller,
Spehar,
Dragovich,
Prins,
Zhou,
Johnson,
Hua,
Luu,
Sakata,
Brown,
Maldonado,
Tuntland,
Lee,
Fuhrman,
Zalman,
Patick,
Matthews,
Wu,
Guo,
Borer,
Nayyar,
Moran,
Chen,
Rejto,
Rose,
Guzman,
Dovalsantos,
Lee,
McGee,
Mohajeri,
Liese,
Tao,
Kosa,
Liu,
Batugo,
Gleeson,
Wu,
Liu,
Meador,
Ferre,
Oleksijew,
Meulbroek,
Ewing,
Jarvis,
Mitten,
Paige,
Tovcimak,
Nukkula,
Chu,
Alder,
Iba,
Nguyen,
Fung,
Li,
Mitscher,
Shen,
Huq,
Tayyem,
Beale,
Yu,
- Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics. Dragovich, P.S., Prins, T.J., Zhou, R., Brown, E.L., Maldonado, F.C., Fuhrman, S.A., Zalman, L.S., Tuntland, T., Lee, C.A., Patick, A.K., Matthews, D.A., Hendrickson, T.F., Kosa, M.B., Liu, B., Batugo, M.R., Gleeson, J.P., Sakata, S.K., Chen, L., Guzman, M.C., Meador, J.W., Ferre, R.A., Worland, S.T. J. Med. Chem. (2002)
- Synthesis and evaluation of 2-pyridinone derivatives as HIV-1 specific reverse transcriptase inhibitors. 1. Phthalimidoalkyl and -alkylamino analogues. Hoffman, J.M., Wai, J.S., Thomas, C.M., Levin, R.B., O'Brien, J.A., Goldman, M.E. J. Med. Chem. (1992)
- Cytotoxicity of platinum (II) dinuclear complexes with 1-alkylthymine ligands against mouse sarcoma 180 cells. Rekonen, P., Dohta, Y., Kodaka, M., Okada, T., Okamoto, K., Okuno, H. J. Med. Chem. (1997)
- 2-Hydroxypyridine metabolism and pigment formation in three Arthrobacter species. Kolenbrander, P.E., Weinberger, M. J. Bacteriol. (1977)
- Efficacy of ABT-719, a 2-pyridone antimicrobial, against enterococci, Escherichia coli, and Pseudomonas aeruginosa in experimental murine pyelonephritis. Meulbroek, J.A., Oleksijew, A., Tanaka, S.K., Alder, J.D. J. Antimicrob. Chemother. (1996)
- An approach to helical tubular self-aggregation using C2-symmetric self-complementary hydrogen-bonding cavity molecules. Stoncius, S., Orentas, E., Butkus, E., Ohrström, L., Wendt, O.F., Wärnmark, K. J. Am. Chem. Soc. (2006)
- The 2-pyridone antibacterial agents: bacterial topoisomerase inhibitors. Li, Q., Mitscher, L.A., Shen, L.L. Medicinal research reviews. (2000)
- X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement. Dvir, H., Jiang, H.L., Wong, D.M., Harel, M., Chetrit, M., He, X.C., Jin, G.Y., Yu, G.L., Tang, X.C., Silman, I., Bai, D.L., Sussman, J.L. Biochemistry (2002)
- Critical nature of a specific uridine O2-carbonyl for cleavage by the hammerhead ribozyme. Bevers, S., Ha, S.B., McLaughlin, L.W. Biochemistry (1999)
- In vivo efficacy of ABT-255 against drug-sensitive and -resistant Mycobacterium tuberculosis strains. Oleksijew, A., Meulbroek, J., Ewing, P., Jarvis, K., Mitten, M., Paige, L., Tovcimak, A., Nukkula, M., Chu, D., Alder, J.D. Antimicrob. Agents Chemother. (1998)
- Synthesis and evaluation of 2-pyridinone derivatives as specific HIV-1 reverse transcriptase inhibitors. 3. Pyridyl and phenyl analogs of 3-aminopyridin-2(1H)-one. Wai, J.S., Williams, T.M., Bamberger, D.L., Fisher, T.E., Hoffman, J.M., Hudcosky, R.J., MacTough, S.C., Rooney, C.S., Saari, W.S., Thomas, C.M. J. Med. Chem. (1993)
- Progression of occlusive atherosclerosis. Long-term administration of pyridinol carbamate. Redisch, W., Clauss, R.H., Rouen, L.R., Katz, M.C., Terry, E.N. Archives of surgery (Chicago, Ill. : 1960) (1975)
- Disturbances of purine nucleotide metabolism in uremia. Rutkowski, B., Swierczynski, J., Slominska, E., Szolkiewicz, M., Smolenski, R.T., Marlewski, M., Butto, B., Rutkowski, P. Semin. Nephrol. (2004)
- Studies on the activity of three palladium(II) compounds of the form: Trans-PdL(2)Cl(2) where L=2-hydroxypyridine, 3-hydroxypyridine, and 4-hydroxypyridine. Huq, F., Tayyem, H., Beale, P., Yu, J.Q. J. Inorg. Biochem. (2007)
- Biochemical criteria for the evaluation of drug efficiency on adjuvant arthritis and nephrotoxic serum nephritis in the rat: studies with phenylbutazone, L-Asparaginase, colchicine, lysine acetylsalicylate, and pyridinol carbamate. Sternberg, M., Peyroux, J., Grochulski, A., Engler, R., Feret, J., Moisy, M., Lagrue, G., Jayle, M.F. Can. J. Physiol. Pharmacol. (1975)
- Metabolism of carcinogenic and non-carcinogenic N-nitroso-N-methylaminopyridines. I. Investigations in vitro. Heydt, G., Eisenbrand, G., Preussmann, R. Carcinogenesis (1982)
- Influence of intermolecular hydrogen bonds on the tautomerism of pyridine derivatives. Alkorta, I., Elguero, J. J. Org. Chem. (2002)
- Asymmetric synthesis of 2-alkyl- and 2-aryl-3-aminopropionic acids (beta2-amino acids) from (S)-N-acryloyl-5,5-dimethyloxazolidin-2-one SuperQuat derivatives. Beddow, J.E., Davies, S.G., Smith, A.D., Russell, A.J. Chem. Commun. (Camb.) (2004)
- CYP1A1 induction by pyridine and its metabolites in HepG2 cells. Iba, M.M., Nguyen, T., Fung, J. Arch. Biochem. Biophys. (2002)
- Pharmacokinetics and bioavailability of pyridinol carbamate in humans. Sassard, J., Bernard, N., Legheand, J., Cuisinaud, G., Traeger, J. Journal of pharmaceutical sciences. (1979)
- Protective effect of pyridinol carbamate in dermal and aortic connective tissue lesions induced by chronic lathyrism. Bouissou, H., Pieraggi, M.T., Julian, M. Pharmacological research communications. (1978)
- Determination of pyridinol carbamate in plasma using high-performance liquid chromatography. Bernard, N., Brazier, J.L., Sassard, J. J. Chromatogr. (1978)
- Metabolism of metyrapone. III. Formation of an alpha-pyridone metabolite by rat hepatic soluble enzymes. Damani, L.A., Crooks, P.A., Cowan, D.A. Drug Metab. Dispos. (1981)
- 2-hydroxypyridine <--> 2-pyridone tautomerization: catalytic influence of formic acid. Hazra, M.K., Chakraborty, T. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2006)
- One-electron oxidation of "photo-Fenton" reagents and inhibition of lipid peroxidation. Tobin, D., Arvanitidis, M., Bisby, R.H. Biochem. Biophys. Res. Commun. (2002)
- Microwave-assisted decarboxylation of bicyclic 2-pyridone scaffolds and identification of Abeta-peptide aggregation inhibitors. Aberg, V., Norman, F., Chorell, E., Westermark, A., Olofsson, A., Sauer-Eriksson, A.E., Almqvist, F. Org. Biomol. Chem. (2005)
- Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. Part 7: structure-activity studies of bicyclic 2-pyridone-containing peptidomimetics. Dragovich, P.S., Prins, T.J., Zhou, R., Johnson, T.O., Brown, E.L., Maldonado, F.C., Fuhrman, S.A., Zalman, L.S., Patick, A.K., Matthews, D.A., Hou, X., Meador, J.W., Ferre, R.A., Worland, S.T. Bioorg. Med. Chem. Lett. (2002)
- Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 8. Pharmacological optimization of orally bioavailable 2-pyridone-containing peptidomimetics. Dragovich, P.S., Prins, T.J., Zhou, R., Johnson, T.O., Hua, Y., Luu, H.T., Sakata, S.K., Brown, E.L., Maldonado, F.C., Tuntland, T., Lee, C.A., Fuhrman, S.A., Zalman, L.S., Patick, A.K., Matthews, D.A., Wu, E.Y., Guo, M., Borer, B.C., Nayyar, N.K., Moran, T., Chen, L., Rejto, P.A., Rose, P.W., Guzman, M.C., Dovalsantos, E.Z., Lee, S., McGee, K., Mohajeri, M., Liese, A., Tao, J., Kosa, M.B., Liu, B., Batugo, M.R., Gleeson, J.P., Wu, Z.P., Liu, J., Meador, J.W., Ferre, R.A. J. Med. Chem. (2003)
- Photochemistry of N-isopropoxy-substituted 2(1H)-pyridone and 4-p-tolylthiazole-2(3H)-thione: alkoxyl-radical release (spin-trapping, EPR, and transient spectroscopy) and its significance in the photooxidative induction of DNA strand breaks. Adam, W., Hartung, J., Okamoto, H., Marquardt, S., Nau, W.M., Pischel, U., Saha-Möller, C.R., Spehar, K. J. Org. Chem. (2002)
- Long term lathyrism and atherogenic diet in the rat. Protective action of pyridinol carbamate. Pieraggi, M.T., De Graeve, J., Julian, M., Thiers, J.C., Bouissou, H. Virchows Archiv. A, Pathological anatomy and histology. (1980)