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Chemical Compound Review

Cymelarsan     N2-[4-[bis(2- aminoethylsulfanyl) arsanyl]ph...

Synonyms: Cymelarsen, melCy, Mel Cy, RM-110, LS-186907, ...
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Disease relevance of Melarsomine


High impact information on Melarsomine


Biological context of Melarsomine


Analytical, diagnostic and therapeutic context of Melarsomine


  1. Affinity chromatography using trypanocidal arsenical drugs identifies a specific interaction between glycerol-3-phosphate dehydrogenase from Trypanosoma brucei and Cymelarsan. Denise, H., Giroud, C., Barrett, M.P., Baltz, T. Eur. J. Biochem. (1999) [Pubmed]
  2. Efficacy of Cymelarsan in the treatment of natural chronic Trypanosoma evansi infection in camels in the Sudan. Musa, M.M., Abdoon, A.M., Nasir, B.T., Salim, Y.I., Abdel-Rahman, A.Y., Shommein, A.M. Revue d'élevage et de médecine vétérinaire des pays tropicaux. (1994) [Pubmed]
  3. Loss of the High-Affinity Pentamidine Transporter Is Responsible for High Levels of Cross-Resistance between Arsenical and Diamidine Drugs in African Trypanosomes. Bridges, D.J., Gould, M.K., Nerima, B., Mäser, P., Burchmore, R.J., de Koning, H.P. Mol. Pharmacol. (2007) [Pubmed]
  4. Trypanosoma brucei: lack of cross-resistance to melarsoprol in vitro by cymelarsan-resistant parasites. Scott, A.G., Tait, A., Turner, C.M. Exp. Parasitol. (1997) [Pubmed]
  5. Alteration to one of three adenosine transporters is associated with resistance to cymelarsan in Trypanosoma evansi. Ross, C.A., Barns, A.M. Parasitol. Res. (1996) [Pubmed]
  6. Induction of resistance to melarsenoxide cysteamine (Mel Cy) in Trypanosoma brucei brucei. Pospichal, H., Brun, R., Kaminsky, R., Jenni, L. Acta Trop. (1994) [Pubmed]
  7. Trypanosoma evansi: in vivo and in vitro determination of trypanocide resistance profiles. Zhang, Z.Q., Giroud, C., Baltz, T. Exp. Parasitol. (1993) [Pubmed]
  8. Cymelarsan in the treatment of buffaloes naturally infected with Trypanosoma evansi in south China. Lun, Z.R., Min, Z.P., Huang, D., Liang, J.X., Yang, X.F., Huang, Y.T. Acta Trop. (1991) [Pubmed]
  9. Evaluation of the efficacy of melarsenoxyde cysteamine (Cymelarsan) in treatment of camels experimentally infected with Trypanosoma evansi using antigen trapping enzyme-linked immunosorbent assay. Nyang'ao, J.M., Olaho-Mukani, W., Maribei, J.M., Omuse, J.K. J. Vet. Pharmacol. Ther. (1995) [Pubmed]
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