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Chemical Compound Review

Becaptan     2-aminoethanethiol

Synonyms: Mercamin, Merkamin, Mercamine, CYSTEAMINE, Cysteinamine, ...
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Disease relevance of Mercaptamine


Psychiatry related information on Mercaptamine


High impact information on Mercaptamine


Chemical compound and disease context of Mercaptamine


Biological context of Mercaptamine

  • Cysteamine-induced ulceration in EGF(-/-) mice was used to examine its role in mucosal cytoprotection [3].
  • We find that the 5,5'-dithobis(2-nitrobenzoic acid)-coupled assay method for cysteamine S-phosphate hydrolysis is not suitable for serum, and we were unable to confirm the existence of this isoenzyme in serum by this assay method [19].
  • The data suggest that oxidative stress by cysteamine can be synergistic with the conditioning heat treatment at 44 degrees C which induces thermotolerance [20].
  • The kinetics of thermotolerance induction and the time to reach the maximum of thermotolerance expression after combined cysteamine treatment at 44 degrees C for 15 min was found to be comparable to the effects of 44 degrees C treatment alone for 30 min [20].
  • Studies with synchronized Chinese hamster cells heated at 43 degrees for 1 hr in the presence of 16 mM cysteamine demonstrated that the potentiation of heat killing occurred in all phases of the cell cycle [21].

Anatomical context of Mercaptamine


Associations of Mercaptamine with other chemical compounds


Gene context of Mercaptamine


Analytical, diagnostic and therapeutic context of Mercaptamine


  1. Improved renal function in children with cystinosis treated with cysteamine. Markello, T.C., Bernardini, I.M., Gahl, W.A. N. Engl. J. Med. (1993) [Pubmed]
  2. Epidermal growth factor inhibits cysteamine-induced duodenal ulcers. Kirkegaard, P., Olsen, P.S., Poulsen, S.S., Nexø, E. Gastroenterology (1983) [Pubmed]
  3. Growth retardation, duodenal lesions, and aberrant ileum architecture in triple null mice lacking EGF, amphiregulin, and TGF-alpha. Troyer, K.L., Luetteke, N.C., Saxon, M.L., Qiu, T.H., Xian, C.J., Lee, D.C. Gastroenterology (2001) [Pubmed]
  4. Intralysosomal cystine accumulation in mice lacking cystinosin, the protein defective in cystinosis. Cherqui, S., Sevin, C., Hamard, G., Kalatzis, V., Sich, M., Pequignot, M.O., Gogat, K., Abitbol, M., Broyer, M., Gubler, M.C., Antignac, C. Mol. Cell. Biol. (2002) [Pubmed]
  5. Attenuating effect of bromocriptine on cysteamine anticarcinogenesis of stomach cancers induced by N-methyl-N'-nitro-N-nitrosoguanidine. Tatsuta, M., Iishi, H., Baba, M., Ichii, M., Nakaizumi, A., Uehara, H., Taniguchi, H. Cancer Res. (1990) [Pubmed]
  6. Cooperative behavior in the thiol oxidation of rabbit muscle glycogen phosphorylase in cysteamine/cystamine redox buffers. Cappel, R.E., Gilbert, H.F. J. Biol. Chem. (1986) [Pubmed]
  7. Huntington's disease: effect of cysteamine, a somatostatin-depleting agent. Shults, C., Steardo, L., Barone, P., Mohr, E., Juncos, J., Serrati, C., Fedio, P., Tamminga, C.A., Chase, T.N. Neurology (1986) [Pubmed]
  8. Acceleration of ageing-related gliopathic changes and hippocampal dysfunction following intracerebroventricular infusion of cysteamine in adult rats. St-Jacques, R., Chapman, A., Lacaille, J.C., Mohr, G., Schipper, H.M. Neuroscience (1999) [Pubmed]
  9. Intrahippocampal injections of cysteamine improve the retention of a bar-pressing task in mice. Guillou, J.L., Micheau, J., Jaffard, R. Behav. Brain Res. (1999) [Pubmed]
  10. Cysteamine-induced depletion of somatostatin produces differential cognitive deficits in rats. DeNoble, V.J., Hepler, D.J., Barto, R.A. Brain Res. (1989) [Pubmed]
  11. Cysteamine therapy for children with nephropathic cystinosis. Gahl, W.A., Reed, G.F., Thoene, J.G., Schulman, J.D., Rizzo, W.B., Jonas, A.J., Denman, D.W., Schlesselman, J.J., Corden, B.J., Schneider, J.A. N. Engl. J. Med. (1987) [Pubmed]
  12. Removal of corneal crystals by topical cysteamine in nephropathic cystinosis. Kaiser-Kupfer, M.I., Fujikawa, L., Kuwabara, T., Jain, S., Gahl, W.A. N. Engl. J. Med. (1987) [Pubmed]
  13. Effects of cysteamine therapy in nephropathic cystinosis. Yudkoff, M., Foreman, J.W., Segal, S. N. Engl. J. Med. (1981) [Pubmed]
  14. Cysteamine: a potent and specific depletor of pituitary prolactin. Millard, W.J., Sagar, S.M., Landis, D.M., Martin, J.B. Science (1982) [Pubmed]
  15. Metabolism of pantethine in cystinosis. Wittwer, C.T., Gahl, W.A., Butler, J.D., Zatz, M., Thoene, J.G. J. Clin. Invest. (1985) [Pubmed]
  16. Accelerated healing of duodenal ulcers by oral administration of a mutein of basic fibroblast growth factor in rats. Szabo, S., Folkman, J., Vattay, P., Morales, R.E., Pinkus, G.S., Kato, K. Gastroenterology (1994) [Pubmed]
  17. Comparative behavioral toxicity of four sulfhydryl radioprotective compounds in mice: WR-2721, cysteamine, diethyldithiocarbamate, and N-acetylcysteine. Landauer, M.R., Davis, H.D., Dominitz, J.A., Weiss, J.F. Pharmacol. Ther. (1988) [Pubmed]
  18. Depletion of pituitary prolactin by cysteamine is due to loss of immunological activity. Scammell, J.G., Dannies, P.S. Endocrinology (1984) [Pubmed]
  19. Serum alkaline phosphatase isoenzymes in lymphoproliferative diseases. Dulis, B., Wilson, I.B. Cancer Res. (1978) [Pubmed]
  20. Influence of oxidative stress induced by cysteamine upon the induction and development of thermotolerance in Chinese hamster ovary cells. Issels, R.D., Bourier, S., Böning, B., Li, G.C., Mak, J.J., Wilmanns, W. Cancer Res. (1987) [Pubmed]
  21. Thermosensitization by sulfhydryl compounds of exponentially growing Chinese hamster cells. Kapp, D.S., Hahn, G.M. Cancer Res. (1979) [Pubmed]
  22. Pantethine and cystamine deplete cystine from cystinotic fibroblasts via efflux of cysteamine-cysteine mixed disulfide. Butler, J.D., Zatz, M. J. Clin. Invest. (1984) [Pubmed]
  23. Effects of cysteamine and antibody to somatostatin on islet cell function in vitro. Evidence that intracellular somatostatin deficiency augments insulin and glucagon secretion. Patel, Y.C., Pierzchala, I., Amherdt, M., Orci, L. J. Clin. Invest. (1985) [Pubmed]
  24. Cysteamine and propionitrile inhibit the rise of duodenal mucosal alkaline secretion in response to luminal acid in rats. Bridén, S., Flemström, G., Kivilaakso, E. Gastroenterology (1985) [Pubmed]
  25. Dopamine disorder in duodenal ulceration. Szabo, S. Lancet (1979) [Pubmed]
  26. Duodenal ulcerogens cysteamine and propionitrile induce gastroduodenal motility alterations in the rat. Pihan, G., Kline, T.J., Hollenberg, N.K., Szabo, S. Gastroenterology (1985) [Pubmed]
  27. Identification of a new structural variant of human apolipoprotein E, E2(Lys146 leads to Gln), in a type III hyperlipoproteinemic subject with the E3/2 phenotype. Rall, S.C., Weisgraber, K.H., Innerarity, T.L., Bersot, T.P., Mahley, R.W., Blum, C.B. J. Clin. Invest. (1983) [Pubmed]
  28. Ethanol-induced damage to mucosal capillaries of rat stomach. Ultrastructural features and effects of prostaglandin F2 beta and cysteamine. Trier, J.S., Szabo, S., Allan, C.H. Gastroenterology (1987) [Pubmed]
  29. Duodenal ulcerogens, cysteamine and propionitrile, stimulate serum gastrin levels in the rat. Lichtenberger, L.M., Szabo, S., Trier, J.S. Gastroenterology (1977) [Pubmed]
  30. Cysteamine and prostaglandin F2 beta stimulate rat gastric mucin release. Lamont, J.T., Ventola, A.S., Maull, E.A., Szabo, S. Gastroenterology (1983) [Pubmed]
  31. Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Szabo, S., Trier, J.S., Brown, A., Schnoor, J. Gastroenterology (1985) [Pubmed]
  32. Blunted prolactin response to thyrotropin-releasing hormone stimulation in cystinotic children receiving cysteamine. Gahl, W.A., Bercu, B.B. J. Clin. Endocrinol. Metab. (1985) [Pubmed]
  33. Effects of cysteamine administration on the in vivo incorporation of [35S]cysteine into somatostatin-14, somatostatin-28, arginine vasopressin, and oxytocin in rat hypothalamus. Cameron, J.L., Fernstrom, J.D. Endocrinology (1986) [Pubmed]
  34. Apolipoprotein E2-Christchurch (136 Arg----Ser). New variant of human apolipoprotein E in a patient with type III hyperlipoproteinemia. Wardell, M.R., Brennan, S.O., Janus, E.D., Fraser, R., Carrell, R.W. J. Clin. Invest. (1987) [Pubmed]
  35. Oral administration of synthetic human urogastrone promotes healing of chronic duodenal ulcers in rats. Skov Olsen, P., Poulsen, S.S., Therkelsen, K., Nexø, E. Gastroenterology (1986) [Pubmed]
  36. Effect of cysteamine on secretion of gastrin and somatostatin from the rat stomach. McIntosh, C., Bakich, V., Trotter, T., Kwok, Y.N., Nishimura, E., Pederson, R., Brown, J. Gastroenterology (1984) [Pubmed]
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