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Chemical Compound Review:

DIOXOLANE 1,3-dioxolane

Synonyms: Glycolformal, SureCN23012, ACMC-1B72J, CCRIS 4912, AG-C-82995, ...

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Disease relevance of DIOXOLANE

Stereoselective photochemical 1,3-dioxolane addition to 5-alkoxymethyl-2(5H)-furanone: synthesis of bis-tetrahydrofuranyl ligand for HIV protease inhibitor UIC-94017 (TMC-114) [1].
A 19-year-old male developed complaints including weakness of the lower extremities and right hand, numbness, dysphagia and urinary difficulties following a 2 month exposure to an industrial solvent constituted mainly of 1-bromopropane, but also containing butylene oxide, 1,3 dioxolane, nitromethane, and other components [2].

High impact information on DIOXOLANE

1,3-Dioxolane-based compounds (2-14) were synthesized, and the pharmacological profiles at alpha(1)-adrenoceptor subtypes were assessed by functional experiments in isolated rat vas deferens (alpha(1A)), spleen (alpha(1B)), and aorta (alpha(1D)) [3].
The HS/GC/MSD analysis performed at 106 degrees C showed that the irradiation generated 668-742 micrograms/kg formic acid, 868-922 micrograms/kg acetic acid, 17-32 micrograms/kg 1,3-dioxolane, and 47-71 micrograms/kg 2-methyl-1, 3-dioxolane based on PET weight [4].

Analytical, diagnostic and therapeutic context of DIOXOLANE

Chiral separation of four 1,3-dioxolane derivatives by supercritical fluid chromatography on an amylose-based column [5].

References

Stereoselective photochemical 1,3-dioxolane addition to 5-alkoxymethyl-2(5H)-furanone: synthesis of bis-tetrahydrofuranyl ligand for HIV protease inhibitor UIC-94017 (TMC-114). Ghosh, A.K., Leshchenko, S., Noetzel, M. J. Org. Chem. (2004) [Pubmed]
Encephalomyeloradiculoneuropathy following exposure to an industrial solvent. Sclar, G. Clinical neurology and neurosurgery. (1999) [Pubmed]
1,3-dioxolane-based ligands as a novel class of alpha1-adrenoceptor antagonists. Brasili, L., Sorbi, C., Franchini, S., Manicardi, M., Angeli, P., Marucci, G., Leonardi, A., Poggesi, E. J. Med. Chem. (2003) [Pubmed]
Volatile and non-volatile compounds in irradiated semi-rigid crystalline poly(ethylene terephthalate) polymers. Komolprasert, V., McNeal, T.P., Agrawal, A., Adhikari, C., Thayer, D.W. Food additives and contaminants. (2001) [Pubmed]
Chiral separation of four 1,3-dioxolane derivatives by supercritical fluid chromatography on an amylose-based column. Bernal, J.L., Toribio, L., del Nozal, M.J., Nieto, E.M., Jiménez, J.J. Journal of chromatography. A. (2000) [Pubmed]

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