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MeSH Review

Deglutition Disorders

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Disease relevance of Deglutition Disorders


Psychiatry related information on Deglutition Disorders

  • The dysphagia of ALS is characterized by an impaired oral stage of swallowing, which has a direct impact on the seemingly more robust pharyngeal stage [6].
  • Dementia, dysphagia, dystonia and seizures, in that sequence, followed within a couple of years [7].

High impact information on Deglutition Disorders


Chemical compound and disease context of Deglutition Disorders


Biological context of Deglutition Disorders

  • Involvement of the dorsal motor nucleus of the vagus might produce dysfunction of muscles controlling deglutition and esophageal motility, thereby leading to drooling, dysphagia, and gastroesophageal reflux [18].
  • When clinical, radiological and manometric data in the seven patients developing peristalsis were compared with findings in the other 20, there were no differences in symptoms, lower oesophageal sphincter pressures and lengths, relief of dysphagia or oesophageal calibre reduction [19].
  • Patients with fluconazole resistance had lower CD4+ cell counts at baseline; more symptoms (P = .0006); a higher frequency of dysgeusia (P = .004), dysphagia (P = .006), and throat pain (P = .0034); and greater oral coverage by plaques of Candida [20].
  • The beneficial effects are described of surgery in relieving severe dysphagia and stridor, and of prednisone in softening and shrinking the hard neck mass [21].
  • BACKGROUND: Congenital cricopharyngeal achalasia is a rare condition in which a newborn presents with dysphagia, choking, nasal reflux, and salivation [22].

Anatomical context of Deglutition Disorders


Gene context of Deglutition Disorders


Analytical, diagnostic and therapeutic context of Deglutition Disorders

  • Although the major goals of anti-reflux procedure are clearly achieved in many severely impaired children with gastroesophageal reflux, the use of Nissen fundoplication to resolve the complications of swallowing disorders and improve outcome with an acceptably low risk in this complex set of patients does not appear to be established [33].
  • A randomised prospective comparison of the Flamingo Wallstent and Ultraflex stent for palliation of dysphagia associated with lower third oesophageal carcinoma [34].
  • A significantly lower incidence of reoperation for failure (1.6% versus 9.6%, OR 0.21, RD -7%, NNT 14) was found after partial fundoplication, with no significant differences regarding the incidence of recurrence and/or dysphagia [35].
  • METHODS AND MATERIALS: A total of 26 patients receiving RT concurrent with gemcitabine, a regimen associated with a high rate of late dysphagia and aspiration, underwent prospective evaluation of swallowing with videofluoroscopy (VF), direct endoscopy, and CT [36].
  • Prednisone was continued with a slow taper, and after 1 month ber dysphagia had resolved and her esophageal manometry was normal [37].


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  2. Patterns of endoscopy use in the United States. Lieberman, D.A., De Garmo, P.L., Fleischer, D.E., Eisen, G.M., Helfand, M. Gastroenterology (2000) [Pubmed]
  3. Omeprazole versus H2-receptor antagonists in treating patients with peptic stricture and esophagitis. Marks, R.D., Richter, J.E., Rizzo, J., Koehler, R.E., Spenney, J.G., Mills, T.P., Champion, G. Gastroenterology (1994) [Pubmed]
  4. Biotin-responsive basal ganglia disease maps to 2q36.3 and is due to mutations in SLC19A3. Zeng, W.Q., Al-Yamani, E., Acierno, J.S., Slaugenhaupt, S., Gillis, T., MacDonald, M.E., Ozand, P.T., Gusella, J.F. Am. J. Hum. Genet. (2005) [Pubmed]
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  6. Swallowing in ALS and motor neuron disorders. Robbins, J. Neurologic clinics. (1987) [Pubmed]
  7. Type C Niemann-Pick disease: report of a Chinese case. Lyu, R.K., Ko, Y.M., Hung, I.J., Lu, C.S. J. Formos. Med. Assoc. (1993) [Pubmed]
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  9. Brain-stem compression in rheumatoid arthritis. Davidson, R.C., Horn, J.R., Herndon, J.H., Grin, O.D. JAMA (1977) [Pubmed]
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  12. Manometric characteristics of cervical dysphagia in a patient with the Kearns-Sayre syndrome. Shaker, R., Kupla, J.I., Kidder, T.M., Arndorfer, R.C., Hofmann, C. Gastroenterology (1992) [Pubmed]
  13. Ethanol-induced tumour necrosis for palliation of malignant dysphagia. Spiller, R.C., Misiewicz, J.J. Lancet (1987) [Pubmed]
  14. Isosorbide dinitrate and nifedipine treatment of achalasia: a clinical, manometric and radionuclide evaluation. Gelfond, M., Rozen, P., Gilat, T. Gastroenterology (1982) [Pubmed]
  15. Esophageal motility during food ingestion: a physiologic test of esophageal motor function. Mellow, M.H. Gastroenterology (1983) [Pubmed]
  16. High esophageal stricture: a complication of "inlet patch" mucosa. Steadman, C., Kerlin, P., Teague, C., Stephenson, P. Gastroenterology (1988) [Pubmed]
  17. Chronic dysphagia and trigeminal anesthesia after trichloroethylene exposure. Lawrence, W.H., Partyka, E.K. Ann. Intern. Med. (1981) [Pubmed]
  18. Gastrointestinal dysfunction in Parkinson's disease: frequency and pathophysiology. Edwards, L.L., Quigley, E.M., Pfeiffer, R.F. Neurology (1992) [Pubmed]
  19. Onset of oesophageal peristalsis after surgery for idiopathic achalasia. Zaninotto, G., Costantini, M., Anselmino, M., Boccù, C., Ancona, E. The British journal of surgery. (1995) [Pubmed]
  20. Assessment of therapeutic response of oropharyngeal and esophageal candidiasis in AIDS with use of a new clinical scoring system: studies with D0870. Hood, S.V., Hollis, S., Percy, M., Atkinson, G., Williams, K., Denning, D.W. Clin. Infect. Dis. (1999) [Pubmed]
  21. Riedel's thyroiditis leading to severe but reversible pituitary failure. Kelly, W.F., Mashiter, K., Taylor, S., Joplin, G.F. Postgraduate medical journal. (1979) [Pubmed]
  22. Congenital cricopharyngeal achalasia: Diagnosis and surgical management. Muraji, T., Takamizawa, S., Satoh, S., Nishijima, E., Tsugawa, C., Tamura, A., Shimizu, N. J. Pediatr. Surg. (2002) [Pubmed]
  23. AGA technical review on treatment of patients with dysphagia caused by benign disorders of the distal esophagus. Spechler, S.J. Gastroenterology (1999) [Pubmed]
  24. September 1999: 24 year old female with progressive lower extremity dystonia, dysarthia, dysphagia and mental impairment. Mourelatos, Z., Golden, J.A. Brain Pathol. (2000) [Pubmed]
  25. Biotin-responsive basal ganglia disease: a novel entity. Ozand, P.T., Gascon, G.G., Al Essa, M., Joshi, S., Al Jishi, E., Bakheet, S., Al Watban, J., Al-Kawi, M.Z., Dabbagh, O. Brain (1998) [Pubmed]
  26. Autosomal dominant cerebellar ataxia type I clinical features and MRI in families with SCA1, SCA2 and SCA3. Bürk, K., Abele, M., Fetter, M., Dichgans, J., Skalej, M., Laccone, F., Didierjean, O., Brice, A., Klockgether, T. Brain (1996) [Pubmed]
  27. Oculopharyngeal muscular dystrophy: phenotypic and genotypic studies in a UK population. Hill, M.E., Creed, G.A., McMullan, T.F., Tyers, A.G., Hilton-Jones, D., Robinson, D.O., Hammans, S.R. Brain (2001) [Pubmed]
  28. Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia. Kuo, Y.M., Duncan, J.L., Westaway, S.K., Yang, H., Nune, G., Xu, E.Y., Hayflick, S.J., Gitschier, J. Hum. Mol. Genet. (2005) [Pubmed]
  29. De novo deletion (14)(q11.2q13) including PAX9: clinical and molecular findings. Schuffenhauer, S., Leifheit, H.J., Lichtner, P., Peters, H., Murken, J., Emmerich, P. J. Med. Genet. (1999) [Pubmed]
  30. Ossification of the cervical anterior longitudinal ligament contributing to dysphagia. Case report. Epstein, N.E., Hollingsworth, R. J. Neurosurg. (1999) [Pubmed]
  31. A retrospective study of percutaneous endoscopic gastrostomy in ALS patients during the BDNF and CNTF trials. Kasarskis, E.J., Scarlata, D., Hill, R., Fuller, C., Stambler, N., Cedarbaum, J.M. J. Neurol. Sci. (1999) [Pubmed]
  32. CD4 lymphocyte count and CD4/CD8 ratio in elderly long-term care patients with oropharyngeal dysphagia: comparison between oral and tube enteral feeding. Leibovitz, A., Sharon-Guidetti, A., Segal, R., Blavat, L., Peller, S., Habot, B. Dysphagia. (2004) [Pubmed]
  33. Nissen fundoplication in children with profound neurologic disability. High risks and unmet goals. Smith, C.D., Othersen, H.B., Gogan, N.J., Walker, J.D. Ann. Surg. (1992) [Pubmed]
  34. A randomised prospective comparison of the Flamingo Wallstent and Ultraflex stent for palliation of dysphagia associated with lower third oesophageal carcinoma. Sabharwal, T., Hamady, M.S., Chui, S., Atkinson, S., Mason, R., Adam, A. Gut (2003) [Pubmed]
  35. Evidence-based appraisal of antireflux fundoplication. Catarci, M., Gentileschi, P., Papi, C., Carrara, A., Marrese, R., Gaspari, A.L., Grassi, G.B. Ann. Surg. (2004) [Pubmed]
  36. Dysphagia and aspiration after chemoradiotherapy for head-and-neck cancer: which anatomic structures are affected and can they be spared by IMRT? Eisbruch, A., Schwartz, M., Rasch, C., Vineberg, K., Damen, E., Van As, C.J., Marsh, R., Pameijer, F.A., Balm, A.J. Int. J. Radiat. Oncol. Biol. Phys. (2004) [Pubmed]
  37. Reversible esophageal motility disorder in a patient with sarcoidosis. Geissinger, B.W., Sharkey, M.F., Criss, D.G., Wu, W.C. Am. J. Gastroenterol. (1996) [Pubmed]
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