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Chemical Compound Review

AG-J-64235     4-(6-imino-5-methyl-3-phenyl- pyridazin-1...

Synonyms: ACMC-20mbvy, SR-95103, CTK0H6570, AR-1F9272, AC1L2PI8, ...
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High impact information on 4-(6-imino-5-methyl-3-phenyl-pyridazin-1-yl)butanoic acid


Anatomical context of 4-(6-imino-5-methyl-3-phenyl-pyridazin-1-yl)butanoic acid

  • When injected into the CG or into the deep layers of the superior colliculus, SR 95103 proved to affect the rat's reactivity to tactile stimuli as evidenced by ipsilateral 'neglect' combined with contralateral hyperreactivity expressed as withdrawal reactions and jumping [4].

Associations of 4-(6-imino-5-methyl-3-phenyl-pyridazin-1-yl)butanoic acid with other chemical compounds

  • In this study, the electroencephalographic (EEG) effects of SR 95103 were investigated as well as its central interaction with inhibitory amino acids and muscimol [5].

Analytical, diagnostic and therapeutic context of 4-(6-imino-5-methyl-3-phenyl-pyridazin-1-yl)butanoic acid

  • The behavioral effects of unilateral microinjections of SR 95103, a new GABA-A receptor antagonist, into periventricular structures were studied [4].
  • These results suggest that the EEG effects of SR 95103 are due to the specific GABAA antagonistic properties of this compound [5].


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