Disease relevance of [1-(2,3-didecoxypropyl)-4-phenyl-4-piperidyl]methanamine

• Cytotoxicity of the alkyl-linked lipoidal amine 4-aminomethyl-1-[2,3-(di-n-decyloxy)-n-propyl]-4-phenylpiperidine (CP-46,665) in cells from human tumors and leukemias [1].
• We investigated the potential benefit of immune stimulation for preventing infection in such conditions in an animal model by evaluating three drugs: Corynebacterium parvum, thymopentin (TP-5), and CP-46,665 [2].
• TP-5 and CP-46,665 may be of benefit to the severely stressed, malnourished surgical patient who is at risk of bacterial infection [2].

High impact information on [1-(2,3-didecoxypropyl)-4-phenyl-4-piperidyl]methanamine

• Scanning electron microscopy revealed loss of cell surface features and severe cell membrane destruction after incubation with CP-46,665 [1].
• CP-46,665 was the most toxic compound, but did not reveal significant differences between nonneoplastic bone marrow and leukemic cells when added in concentrations greater than 1 microgram/ml [3].
• Two immunomodulators, thymopentin (TP-5) and CP-46,665, have been shown to improve survival in infectious animal models of such deficiencies [4].
• Lack of therapeutic activity of the lipoidal amine CP-46,665 in rodent tumors and human non-seminomatous germ cell tumors growing in nude mice [5].

References